2917-91-1Relevant articles and documents
LE CHLOROALLYLLITHIUM COMME SYNTHON DE CHLOROALLYLATION OU COMME EQUIVALENT DU VINYLCARBENE: SYNTHESE REGIOSELECTIVE D'ALCOOLS γ-ETHYLENIQUES β-CHLORES ET DE VINYL-2 OXETANES A PARTIR D'EPOXYDES
Ongoka, P.,Mauze, B.,Miginiac, L.
, p. 139 - 148 (1985)
Chloroallyllithium reacts regioselectively with various epoxides in a "one-pot" reaction to produce either γ-ethylenic β-chloro alcohols or 2-vinyl oxetanes, depending on the experimental conditions used.
Use of quaternary polysiloxanes in cleaning and care compositions
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Page/Page column 11, (2008/06/13)
The invention relates to the use of polysiloxanes which comprise a plurality of quaternary ammonium groups in the molecule in cosmetic or pharmaceutical compositions for the cleaning and care of keratin fibers, in particular of human hair. The improvement in the shine and in the color protection of the hair is achieved if the polysiloxanes are used in an amount in the range from 0.01 to 30%.
Treatment of excessive osteolysis with indolinone compounds
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, (2008/06/13)
Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.
3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors
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, (2008/06/13)
The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.
Treatment of acute myeloid leukemia with indolinone compounds
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, (2008/06/13)
A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.
Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives
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, (2008/06/13)
The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.
2-Amino-5-aminomethyl-2-oxazolines, compositions and use
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, (2008/06/13)
This invention relates to new 2-amino-5-aminomethyl-2-oxazolines, the method of preparing them, and their pharmacological properties making possible their application in cardiovascular, psychotropic, antiinflammatory antiallergic, antihistamine, antiH2 therapy. These new products have the general formula: STR1 wherein R1 and R2 independently represent an alkyl radical of C1 to C4, or a carbocyclic alkyl radical having less than 4 rings, or a carbocyclic radical having less than 4 rings; R1 and R2 can form, with the nitrogen atom to which they are attached, a 4 to 7 member heterocycle containing 1 or 2 nitrogen atoms, and either 1 or 0 oxygen atoms. This heterocycle can be substituted by R with R being a lower alkyl, allyl, benzyl, pyridyl, phenyl substituted or not by one or more substituents such as halogen, trifluoromethyl, methyl, methoxy, hydroxy.
