6322-01-6

Basic information

• Product Name: 1-AMINO-3-DIETHYLAMINO-2-PROPANOL
• Synonyms: TIMTEC-BB SBB010310;1-AMINO-3-DIETHYLAMINO-2-PROPANOL;IFLAB-BB F2137-0019;Einecs 228-676-4
• CAS NO: 6322-01-6
• Molecular Formula: C₇H₁₈N₂O
• Molecular Weight: 146.23
• EINECS: 228-676-4
• Mol File: 6322-01-6.mol

Chemical Properties

• Boiling Point: 265.87°C (rough estimate)
• Flash Point: 88.7°C
• Appearance: /
• Density: 0.9310
• Vapor Pressure: 0.0201mmHg at 25°C
• Refractive Index: 1.4650 (estimate)
• CAS DataBase Reference: 1-AMINO-3-DIETHYLAMINO-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-3-DIETHYLAMINO-2-PROPANOL(6322-01-6)
• EPA Substance Registry System: 1-AMINO-3-DIETHYLAMINO-2-PROPANOL(6322-01-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 6322-01-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Amino-3-diethylamino-2-propanol is used as a raw material for the synthesis of various pharmaceuticals due to its ability to participate in a range of chemical reactions, enhancing the development of new drugs and therapeutic agents.
Used in Chemical Industry:
ADEP is used as a chelating agent for its capacity to bind metal ions, which is crucial in processes that require the stabilization or separation of metal-containing compounds.
Used in Surfactant and Detergent Production:
1-Amino-3-diethylamino-2-propanol is used as a component in the production of surfactants and detergents, leveraging its chemical properties to improve the performance and effectiveness of these cleaning agents.

InChI:InChI=1/C7H18N2O/c1-3-9(4-2)6-7(10)5-8/h7,10H,3-6,8H2,1-2H3/t7-/m0/s1

Upstream product

• 2917-91-1 glycidyldiethylamine 
• 15285-59-3 1-chloro-3-diethylaminopropan-2-ol 
• 7664-41-7 ammonia 
• 109-89-7 diethylamine 
• 19667-37-9 2-(3-chloro-2-hydroxypropyl)-1H-isoindole-1,3(2H)-dione 
• 64-17-5 ethanol 

Downstream Products

• 17220-91-6 1-(5-Chloro-2,4-dinitro-phenylamino)-3-diethylamino-propan-2-ol 
• 17215-66-6 1-Diethylamino-3-[5-(3-diethylamino-2-hydroxy-propylamino)-2,4-dinitro-phenylamino]-propan-2-ol 
• 56224-02-3 1-Diethylamino-3-(5-methoxy-2,4-dinitro-phenylamino)-propan-2-ol 
• 56224-12-5 1-(2-Chloro-4,6-dinitro-phenylamino)-3-diethylamino-propan-2-ol 
• 17215-76-8 1-Diethylamino-3-[5-(2-dimethylamino-ethylamino)-2,4-dinitro-phenylamino]-propan-2-ol 
• 17214-31-2 1-Diethylamino-3-[5-(2-diethylamino-ethylamino)-2,4-dinitro-phenylamino]-propan-2-ol 
• 56223-78-0 1-(4-Chloro-5-methoxy-2-nitro-phenylamino)-3-diethylamino-propan-2-ol 
• 56224-97-6 1-(5-Amino-2,4-dinitro-phenylamino)-3-diethylamino-propan-2-ol 
• 56224-07-8 1-(3,6-Diethoxy-2,4-dinitro-phenylamino)-3-diethylamino-propan-2-ol 
• 73480-63-4 N-(3-Diethylamino-2-hydroxy-propyl)-2-methylamino-benzamide 
• 87416-04-4 N-(2-Hydroxy-3-diethylaminopropyl)diphenylacetamide 
• 87416-05-5 N-(2-Hydroxy-3-diethylaminopropyl)-α-methoxydiphenylacetamide 
• 111380-69-9 1-(3-Diethylamino-2-hydroxy-propylamino)-4,5-dimethyl-5H-pyrido[4,3-b]indol-8-ol 
• 83200-08-2 2-[3-(N,N-diethylamino)-2-hydroxypropylaminocarbonyl]-3-methoxy-1-phenylindole 

Relevant articles and documents

Treatment of excessive osteolysis with indolinone compounds

Compounds of Formula I and Formula II, as described herein, are useful for treating excessive osteolysis, by inhibiting M-CSF mediated osteoclast development. The compounds also are useful for inhibiting phosphorylation of CSF1R, and for treating cancers that express CSF1R.

3-(4-amidopyrrol-2-ylmethylidene)-2-indolinone derivatives as portein kinase inhibitors

The present invention relates to pyrrole substituted 2-indolinone compounds and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefore are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

Treatment of acute myeloid leukemia with indolinone compounds

A method of treating acute myeloid leukemia in patient positive for FLT-3-ITD is described. The treatment is accomplished by administration of a compound of Formula I or II as defined herein.

Mannich base prodrugs of 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives

The present invention is directed to Mannich base prodrugs of certain 3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives that modulate the activity of protein kinases (“PKs”). Pharmaceutical compositions comprising these compounds, methods of treating diseases related to abnormal PK activity utilizing pharmaceutical compositions comprising these compounds and methods of preparing them are also disclosed.