- P-Sulfonic acid calixarenes as efficient and reusable organocatalysts for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones
-
A new and efficient methodology is proposed for obtaining 3,4-dihydropyrimidin-2(1H)-ones/-thiones through Biginelli reactions. It is based on the use of less than the stoichiometric amount ofp-sulfonic acid calixarenes as organocatalysts. A number of aro
- Da Silva, Daniel L.,Fernandes, Sergio A.,Sabino, Ad?o A.,De Fá, ?ngelo
-
-
Read Online
- Microwave assisted synthesis of some novel pyrimidinones/thiones
-
A novel scries of 1-substituted-4-aryl-5-ethoxycarbonyl-6-mcthylpyrimidine- 2-ones/thiones are prepared in the one pot condensation of appropriate aldehyde, ethylacetoacetate and substituted urea in ethanol medium under microwave irradiation. The new compounds are well characterized by IR,1H NMR, mass spectra, C.H,N-analysis and in a typical example the structure was further confirmed by X-ray crystallographic data.
- Rai, Satheesha N.,Kalluraya, Balakrishna,Lingappa,Shenoy, Shalini
-
experimental part
p. 1431 - 1434
(2010/03/03)
-
- Convenient one pot synthesis of some novel derivatives of thiazolo[2,3-b]dihydropyrimidinone possessing 4-methylthiophenyl moiety and evaluation of their antibacterial and antifungal activities
-
A series of new 2-(arylidene/5-arylfurfurylidene)-5-(4-methylthiophenyl)-6-carbethoxy-7- methyl-5H-thiazolo[2,3-b]pyrimidin-3(1H)-ones 2 and 3 have been synthesized by a three component (MCR) reaction involving 4-(4-methylthiophenyl)-5-carbethoxy-6-methyl-3,4-dihydropyrimidin-2(1H)- thione 1, monochloroacetic acid and arylaldehydes/arylfurfuraldehydes, respectively. The newly synthesized compounds were well characterized by elemental analysis, IR, 1H NMR and mass spectral studies. The newly synthesized compounds were screened for their antibacterial and antifungal activities and have exhibited moderate to excellent growth inhibition of bacteria and fungi. The results of such studies have been discussed in this paper.
- Ashok, Mithun,Holla, Bantwal Shivarama,Kumari, Nalilu Suchetha
-
p. 380 - 385
(2008/02/01)
-