- Contemporary development in sequential Knoevenagel, Michael addition multicomponent reaction for the synthesis of 4-Aryl-5-oxo-5H-indeno[1,2-b]pyridine-3-carbonitrile
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An uncatalyzed efficient synthesis of bioactive pyridine derivatives has been investigated for the first time by a three-component sequential multicomponent reaction tackled with aromatic aldehydes, malononitrile, and 1,3-indandione via Knoevenagel condensation followed by Michael addition. The difference between the domino multicomponent and sequential multicomponent reaction is emphasized by this methodology. The reaction proceeds at ambient temperature without frequently useful N-source like ammonium salt for the construction of N-heterocycles, which makes this protocol a novel synthetic route for the preparation of the indenopyridine skeleton.
- Patravale, Ajinkya A.,Gore, Anil H.,Patil, Dipti R.,Kolekar, Govind B.,Deshmukh, Madhukar B.,Choudhari, Prafulla B.,Bhatia, Manish S.,Anbhule, Prashant V.
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Read Online
- Synthesis of novel 15-aryl-2,3,4,15-tetrahydrochromeno[2′,3′:4,5] pyrimido[6,1-b]quinazoline-1,9-diones
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A new series of 15-aryl-2,3,4,15-tetrahydrochromeno[2′,3′:4,5]pyrimido[6,1-b]quinazoline-1,9-diones was synthesised by the cyclisation of methyl anthranilate with ethyl N-(3-cyano-5-oxo-4-aryl-5,6,7,8-tetrahydro-4H-chromen-2-yl)formimidate derivatives, wh
- Kong, Xiu-Xiu,Cao, Yong-Nan,Xing, Zheng,Chen, Li-Zhuang,Han, Guang-Fan
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Read Online
- Enzymes inhibition profiles and antibacterial activities of benzylidenemalononitrile derivatives
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The activities of enzymes can be targeted in the treatment of some diseases. Recently, this strategy has been used frequently in the development of new drugs. Carbonic anhydrase isozymes (CA-I and CA-II) and acetylcholine esterase (AChE) are some of these
- Güller, P?nar,Da?alan, Ziya,Güller, U?ur,?al???r, Ula?,Ni?anc?, Bilal
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Read Online
- Size and function influence study on enhanced catalytic performance of a cooperative MOF for mild, green and fast C-C bond formation
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Tuning of pore function and size (surface area) are two key factors that play important roles in the performance of metal-organic-frameworks (MOFs) as catalysts. The catalytic performance of two bulk and nanosized MOFs with different functional groups suc
- Morsali, Ali,Ramazani, Ali,Rouhani, Farzaneh,Varnaseri, Najmeh
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Read Online
- Synthesis of novel ethyl 1-Aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5] pyrimido[6,1-b]quinazoline-2-carboxylate derivatives
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In this paper, a new series of ethyl 1-Aryl-3-methyl-8-oxo-1,8-dihydropyrano[2′,3′:4,5]pyrimido[6,1-b]quinazoline-2-carboxylate derivatives was synthesised by the cyclisation of methyl anthranilate with ethyl 5-cyano-6-[(ethoxymethylene)amino]-2-methyl-4-
- Shi, Qiu-Zhong,Cao, Yong-Nan,Ma, Shi-Bing,Wang, Guo-Xi,Han, Guang-Fan,Xing, Zheng
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Read Online
- A Simplistic Approach for Preparation of Alkylidenemalononitrile Derivatives: Characterization, In silico Studies, Quantum Chemical Evaluation, Molecular Docking, and In vitro Biological Activity Evaluation
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A new and efficient green grinding-based catalyst free Knoevenagel condensation of aldehydes/ketones and malononitrile for the rapid preparation of twelve malononitrile derivatives (C1-C12) is proposed. Characterization of the derivatives was done by sup
- Ahmad, Rumana,Azad, Iqbal,Kamal, Azhar,Khan, Abdul Rahman,Khan, Tahmeena,Nasibullah, Malik
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- Highly active zinc oxide-supported lithium oxide catalyst for solvent-free Knoevenagel condensation
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Li2O/ZnO catalyst was prepared by wet impregnation method and characterized by XRD, SEM, EDX, FTIR, BET surface area and UV-Vis diffuse reflectance spectroscopy. This study revealed a decrease in average particle size and change in the shape of
- Basude, Manohar,Bhongiri, Yadagiri,Masula, Keshavulu,Pasala, Vijay Kumar,Puppala, Veerasomaiah,Sunkara, Prasad
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- Pseudo-Five-Component Stereoselective Synthesis of Highly Functionalized 3-Azabicyclo[3.3.1]nona-2,7-dienes
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Abstract: The reaction of aromatic aldehydes with malononitrile, ethyl or butyl cyanoacetate and acetylacetone in the presence of NaOH under mild conditions (EtOH, 25°C) led to the formation of new series of (1S,5R,6R,9R)/(1R,5S,6S,9S)-2-amino-6,9-diaryl-
- Aksenov, N. A.,Aksenova, I. V.,Dotsenko, V. V.,Ismiyev, A. I.,Magarramov, A. M.
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p. 758 - 767
(2021/06/28)
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- Supported copper on a diamide-diacid-bridged PMO: an efficient hybrid catalyst for the cascade oxidation of benzyl alcohols/Knoevenagel condensation
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In this study, a novel periodic mesoporous organosilica (PMO) containing diamide-diacid bridges was conveniently prepared using ethylenediaminetetraacetic dianhydride to support Cu(ii) species and affording supramolecular Cu@EDTAD-PMO nanoparticles efficiently. Fourier transform infrared (FT-IR) and energy dispersive X-ray (EDX) spectroscopy, thermogravimetric analysis (TGA), X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), Brunauer-Emmett-Teller (BET) analysis, and high-resolution transmission electron microscopy (HRTEM) results confirmed the successful synthesis of Cu@EDTAD-PMO. The stabilized Cu(ii) nanoparticles inside the mesochannels of the new PMO provided appropriate sites for selective oxidation of different benzyl alcohol derivatives to their corresponding benzaldehydes and subsequent Knoevenagel condensation with malononitrile. Therefore, Cu@EDTAD-PMO can be considered as a multifunctional heterogeneous catalyst, which is prepared easily through a green procedure and demonstrates appropriate stability with almost no leaching of the Cu(ii) nanoparticles into the reaction medium, and easy recovery through simple filtration. The recycled Cu@EDTAD-PMO was reused up to five times without significant loss of its catalytic activity. The stability, recoverability, and reusability of the designed heterogeneous catalyst were also studied under various reaction conditions.
- Dekamin, Mohammad G.,Valiey, Ehsan
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p. 437 - 450
(2022/01/20)
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- Synthesis of 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes from the same reactants by using metal-free catalyst
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A facile and rapid multicomponent synthesis of pharmaceutically diverse 1H-isochromenes, 4H-chromenes, and ortho-aminocarbonitrile tetrahydronaphthalenes has been developed from benzaldehyde, malononitrile, and cyclohexanone. Three different methods from the same reactants, solvent, temperature, and catalyst lead to three products with excellent yields. All the reactions were followed with the Michael addition and cyclization. In this study, morpholine was used as an active metal-free base catalyst that increases the yields of products and decreases the time of reactions.
- Naeimi, Hossein,Mohammadi, Somaye
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supporting information
p. 50 - 59
(2019/12/27)
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- Calcined Dolomite: An Efficient and Recyclable Catalyst for Synthesis of Α, Β-Unsaturated Carbonyl Compounds
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Abstract: Calcined dolomite was utilized as a low-cost and efficient catalyst for the Knoevenagel condensation of aldehydes with active methylene compounds such as malononitrile and ethyl cyanoacetate to afford substituted α, β-unsaturated carbonyl compou
- Yang, Hongyuan,Dong, Hao,Zhang, Tengfei,Zhang, Qi,Zhang, Guangwei,Wang, Peng,Liu, Qing
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p. 778 - 787
(2019/01/04)
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- Diastereoselective construction of a functionalized dihydro-pyridazine-based spirooxindole scaffold: Via C-3 umpolung of isatin N, N ′-cyclic azomethine imine
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Herein, functionalized spiro[indoline-3,5′-pyrazolo[1,2-a]pyridazine]-7′-carbonitrile containing two contiguous chiral stereocenters was efficiently synthesized in a satisfactory yield (up to 91% yield) and with excellent diastereoselectivity. We have rea
- Moghaddam, F. Matloubi,Eslami,Siahpoosh,Hoda
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supporting information
p. 10318 - 10323
(2019/07/08)
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- Access to thiomorpholin-3-one derivatives: [3 + 3]-cycloadditions of α-chlorohydroxamates and 1,4-dithiane-2,5-diol
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A protocol of [3 + 3]-cycloaddition was proposed for the synthesis of 2H-1,4-thiazin-3(4H)-ones and thiomorpholine-3,5-diones from α-chlorohydroxamates and 1,4-dithiane-2,5-diol. This direct and practical method provides a novel and rapid approach for the
- He, Zhao-Lin,Chen, Yi,Wang, Xiaohua,Ni, Mingwang,Wang, Gang
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- Knoevenagel reaction catalyzed by a reusable Br?nsted acid based on 1-alkyl-1, 2, 4-triazolium tetrafluoroborate
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The Knoevenagel reaction is one of the most useful methods for the synthesis of α, β- unsaturated nitriles. We disclose an efficient protocol for the Knoevenagel reaction of aldehydes with malononitrile catalyzed by 1-alkyl-1, 2, 4-triazolium salts to aff
- Kandasamy, Elango,Nagarajan, Sankaranarayanan,Shaikh, Tanveer M.
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supporting information
p. 133 - 138
(2018/03/06)
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- TEDETA@BNPs as a basic and metal free nanocatalyst for Knoevenagel condensation and Hantzsch reaction
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In this work, Boehmite nanoparticles (BNPs) were synthesized in water using commercially available materials and further N,N,N′,N′-tetraethyldiethylentriamin (TEDETA) was supported on the surface of BNPs, and used as organo-basic catalyst in four-componen
- Ghorbani-Choghamarani, Arash,Heidarnezhad, Zahra,Tahmasbi, Bahman,Azadi, Gouhar
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p. 2281 - 2293
(2018/08/28)
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- Synthesis and characterization of the immobilized Ni-Zn-Fe layered double hydroxide (LDH) on silica-coated magnetite as a mesoporous and magnetically reusable catalyst for the preparation of benzylidenemalononitriles and bisdimedones (tetraketones) under
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Herein, novel magnetic Fe3O4@SiO2@Ni-Zn-Fe layered double hydroxide (LDH) intercalated with water molecules and carbonate anions as interlayer contents was prepared as a new heterogeneous and separable nanocatalyst. The me
- Gilanizadeh, Masumeh,Zeynizadeh, Behzad
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p. 8553 - 8566
(2018/06/08)
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- Binary copper and iron oxides immobilized on silica-layered magnetite as a new reusable heterogeneous nanostructure catalyst for the Knoevenagel condensation in water
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Abstract: In this study, a novel heterogeneous and reusable nanostructure catalyst was synthesized through the immobilization of bimetallic Cu–Fe mixed oxides on silica-layered magnetite. The prepared nanomagnetic Fe3O4@SiO2/su
- Gilanizadeh, Masumeh,Zeynizadeh, Behzad
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p. 6053 - 6070
(2018/05/26)
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- Synthesis of Polyfunctionalized Pyrroles via Green Chemical Methods
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Water was found to be an excellent solvent for the one-pot synthesis of tetrasubstituted pyrrole derivatives under ultrasound involving the standard Knoevenagel condensation followed by the Michael type reaction. A new catalyst free system, excellent atom
- Pagadala, Ramakanth,Anugu, Sreenivasa
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p. 181 - 186
(2017/10/30)
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- The clean synthesis and confirmatory structural characterization of new 2-amino-4,8-dihydropyrano[3,2-b]pyran-3-cyano based on Kojic acid
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Abstract: A valuable and clean method was developed for the synthesis of the group of different novel 2-amino-4,8-dihydropyrano[3,2-b]pyran-3-carbonitriles containing a 2-aminopyran moiety by using of azido kojic acid and various 2-arylidinemalononitriles in the presence of NH4Cl as a catalyst in a green solvent (ethanol) with excellent yields. All structures were analyzed by FT-IR, 1H, 13C NMR spectroscopy, and representatively, one compound was analyzed by X-ray crystallography technique. Crystallographic analyses indicated that of this compound a dimer formed via two weak intermolecular hydrogen bonds with d(N···O) distances of 2.927?? and made a 14-membered ring with centrosymmetric (Ci) form. Graphical abstract: [Figure not available: see fulltext.].
- Aghbash, Khadijeh Ojaghi,Pesyan, Nader Noroozi,Notash, Behrouz
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p. 2059 - 2067
(2018/09/14)
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- Preparation of a superior liquid catalyst by hybridization of three solids of nanoZnO, urea, and choline chloride for Knoevenagel-based reactions
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Abstract: The complex catalyst of [ZnClO.urea]?[Ch.urea]+ has been prepared by dissolving of nanoZnO in choline chloride:2urea at 50 °C. The concentration of [ZnClO.urea]? in the given liquid is 19,987 ppm and 10.5 times h
- Tamaddon, Fatemeh,Azadi, Davood
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p. 2077 - 2086
(2017/09/13)
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- Porous hierarchical magnesium oxide-based heterogeneous catalyst for the Knoevenagel condensation
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Herein, an operationally facile and efficient Knoevenagel reaction catalyzed by porous hierarchical MgO/Mg(OH)2 is presented. Condensation of various aldehydes with malononitrile proceeds under mild conditions and gives the target products with
- Deilami,Sayyahi
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p. 1085 - 1086
(2017/06/29)
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- Effective and Green One-Pot Multicomponent Synthesis of Novel Derivatives of 4H-Pyrans in the Presence of Hexamethylenetetramine as Catalyst in Water Medium
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Hexamethylenetetramine catalyzes synthesis of new polyfunctionalized 4H-pyrans by the reaction of aromatic aldehyde, malononitrile, and β-keto esters via one-pot three-component procedure in water medium. Addition of reactants was performed by two methods
- Habibi, Maysam,Habibi, Azizollah,Hakimi Nasab, Saber,Dolati, Hadi,Mahdavi, Seyedeh Mahbobeh
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p. 1598 - 1603
(2017/03/27)
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- RETRACTED ARTICLE: Effective and Green One-Pot Multicomponent Synthesis of Novel Derivatives of 4H-Pyrans in the Presence of Hexamethylenetetramine as Catalyst in Water Medium
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Hexamethylenetetramine (HMTA) catalyzes synthesis of new polyfunctionalized 4H-pyrans by reaction of aromatic aldehyde, malononitrile, and β-keto esters via one-pot three-component procedure in water medium. Addition of reactants was performed by two meth
- Habibi, Maysam,Habibi, Azizollah,Hakimi Nasab, Saber,Dolati, Hadi,Mahdavi, Seyedeh Mahbobeh
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p. 1880 - 1886
(2017/05/29)
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- Green one-pot synthesis of novel polysubstituted pyrazole derivatives as potential antimicrobial agents
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Various biological properties of natural and synthetic pyrazole derivatives such as anti-inflammatory, antimicrobial, neuroprotective, anticonvulsant, antidepressant and anticancer activities encouraged us to propose a new, fast, green and eco-friendly pr
- Beyzaei, Hamid,Motraghi, Zahra,Aryan, Reza,Zahedi, Mohammad Mehdi,Samzadeh-Kermani, Alireza
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p. 911 - 918
(2018/01/17)
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- Ultrasound promoted synthesis of arylmethylenemalonitriles catalyzed by melamine
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Arylmethylenemalonitriles were synthesized in the presence of melamine through the Knoevenagel condensation of aldehydes with malononitrile in ethanol. Two strategies such as the conventional stirring and ultrasound-assisted method were performed in this
- Liu, Qing,Ai, Hong Mei
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p. 565 - 569
(2016/08/26)
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- New facile, eco-friendly and rapid synthesis of trisubstituted alkenes using bismuth nitrate as lewis acid
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Background: For the synthesis of tri and tetra-substituted alkenes, Knoevenagel condensations have previously been performed in solvents like dichloromethane, DMF, toluene, acetonitrile, DMSO etc. These conditions suffer from certain limitations like long
- Muhammad, Munira T.,Khan, Khalid M.,Taha, Muhammad,Khan, Tariq,Hussain, Shafqat,Fakhri, Muhammad I.,Perveen, Shahnaz,Voelter, Wolfgang
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p. 231 - 235
(2016/03/01)
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- An Efficient One-pot Three-component Process for Synthesis of Perfluoroalkylated Quinolizines
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A facile multi-component process for the synthesis of perfluoroalkylated quinolizine derivatives was achieved using various arylidenemalononitriles, pyridine, and methyl perfluoroalk-2-ynoates as starting materials. Moderate yields were obtained under mil
- Shen, Dandan,Xu, Yanjie,He, Dong,Han, Jing,Chen, Jie,Deng, Hongmei,Shao, Min,Zhang, Hui,Cao, Weiguo
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p. 524 - 532
(2016/06/01)
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- A catalyst free, multicomponent-tandem, facile synthesis of pyrido[2,3-d]pyrimidines using glycerol as a recyclable promoting medium
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A clean and efficient, multicomponent-tandem strategy for the synthesis of pyrido[2,3-d]pyrimidines is reported in glycerol, a biodegradable and reusable promoting medium. The advantages of the present methodology includes a one-pot catalyst free environm
- Singh, Swastika,Saquib, Mohammad,Singh, Mandavi,Tiwari, Jyoti,Tufail, Fatima,Singh, Jaya,Singh, Jagdamba
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- Visible light promoted synthesis of dihydropyrano[2,3-c] chromenes via a multicomponent-tandem strategy under solvent and catalyst free conditions
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The development of unique, mild and efficient one pot, multicomponent-tandem synthesis of highly functionalized dihydropyrano[2,3-c]chromenes under photochemical activation is reported. The key feature of the present work is the utilization of visible lig
- Tiwari, Jyoti,Saquib, Mohammad,Singh, Swastika,Tufail, Fatima,Singh, Mandavi,Singh, Jaya,Singh, Jagdamba
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supporting information
p. 3221 - 3231
(2016/06/13)
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- Cinchona alkaloid and di-: Tert -butyldicarbonate-DMAP promoted efficient synthesis of (E)-nitroolefins
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The synthesis of nitroolefins from aldehydes and olefins is generally limited by the formation of a mixture of cis and trans compounds. Here we report an alternative, metal-free protocol for the synthesis of β-nitroolefins from arylidinemalononitrile using cinchona alkaloid along with di-tert-butyldicarbonate-DMAP in high yields with total selectivity.
- Poomathi, Nataraj,Perumal, Paramasivan T.
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p. 54495 - 54502
(2016/07/06)
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- Synthesis of Activated Cyclopropanes by MHIRC Strategy: A Facile and Efficient Approach to Spirocyclopropanes Using N-Halosulfon-amides
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In this study, a one-pot, three-component reaction of two molecules of indane-1,3-dione with aromatic aldehydes for the synthesis of spirocyclopropylindanediones using poly(N-bromo-N-ethylbenzene-1,3-disulfonamide) (PBBS), N,N,N',N'-tetrabromobenzene-1,3-
- Ghorbani-Vaghei, Ramin,Maghbooli, Yaser
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p. 3803 - 3811
(2016/10/30)
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- An efficient five-component synthesis of thioether containing dihydropyrano[2,3-c]pyrazoles: a green domino strategy
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An efficient route for the synthesis of novel thioether containing dihydropyrano[2,3-c]pyrazoles has been accomplished via a solvent-free, catalyst-free, one-pot, five component domino strategy. This synthetic approach offers several advantages such as an easy work-up, no need for purification techniques and a short reaction time with good atom economy and high yields of the products (81-86%).
- Ramesh, Vediyappan,Shanmugam, Sivakumar,Devi, Natarajan Savitha
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p. 9993 - 10001
(2016/12/07)
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- Synthesis and characterization of Al2O3-SiO2-MgO nanocomposite prepared by sol-gel process as an efficient catalyst for the Knoevenagel condensation of aldehydes with malononitrile
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Abstract The composite of Al2O3-SiO2 and Al2O3-SiO2-MgO nanocomposite were synthesized by sol-gel method and FT-IR, XRD, FE-SEM, EDAX, TEM, and BET surface area analysis were used to charac
- Mobarakeh, Mahmood Iranpour,Saffar-Teluri, Ali,Tabrizi, S. A. Hassanzadeh
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p. 6625 - 6633
(2015/02/19)
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- Efficient tandem synthesis of a variety of pyran-annulated heterocycles, 3,4-disubstituted isoxazol-5(4H)-ones, and α,β-unsaturated nitriles catalyzed by potassium hydrogen phthalate in water
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A variety of 4H-chromenes, benzochromenes, 4,5-dihydropyrano[3,2-c]chromenes, 4H-pyran-3-carboxylates, and 3,4-disubstituted isoxazol-5(4H)-ones have been synthesized in high yields by using potassium hydrogen phthalate (KHP) as an inexpensive, commercially available catalyst. It was found that the three-component tandem reaction enabled synthesis of pyran-annulated heterocycles in water at 50 °C. 3,4-Disubstituted isoxazol-5(4H)-ones were synthesized by use of 10 mol% KHP in water at room temperature. Also, treatment of methylene-containing compounds (malononitrile or ethyl cyanoacetate) with aromatic aldehydes in the presence of 5 mol% KHP resulted in α,β-unsaturated nitriles. The procedure is an easily performed, straightforward method for synthesis of a variety of pyran-annulated compounds, isoxazol-5(4H)-one-containing heterocycles, and Knoevenagel adducts. The reaction is safe, uses mild conditions, and is environmentally benign. Other notable advantages are reuse of the catalyst, no use of hazardous organic solvents, and ease of work-up.
- Kiyani, Hamzeh,Ghorbani, Fatemeh
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p. 7847 - 7882
(2015/02/19)
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- Ultrasound-promoted knoevenagel condensation catalyzed by KF-clinoptilolite
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Potassium fluoride-clinoptilolite, which is prepared from commercially available and cheap starting materials, was used as an efficient and recyclable catalyst for Knoevenagel condensation of aromatic aldehydes with active methylene compounds under ultras
- Keipour, Hoda,Hosseini, Abolfazl,Khalilzadeh, Mohammad A.,Ollevier, Thierry
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p. 645 - 650
(2015/11/09)
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- Knoevenagel condensation of aromatic aldehydes with active methylene compounds catalyzed by lipoprotein lipase
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A screening of using different lipases to catalyze the Knoevenagel reaction was realized, and lipase lipoprotein (LPL) from Aspergillus niger showed the best catalytic performance. The reaction conditions including solvent, enzyme loading, and temperature were screened to improve the reaction efficiency. Various kinds of substrates were investigated, and almost all the target products were obtained in good to excellent yields (76-98%) with Z configuration exclusively. This procedure provides a novel, green and efficient method for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds.
- Ding, Yan,Ni, Xiao,Gu, Mengjie,Li, Shuang,Huang, He,Hu, Yi
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p. 101 - 104
(2015/02/19)
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- Synthesis of novel 9,9-dimethyl-8,12-dihydro-9H-chromeno[3,2-e] [1,2,4] triazolo[1,5-c]pyrimidin-11(10H)-one derivatives
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Novel 9,9-dimethyl-8,12-dihydro-9H-chromeno[3,2-e][1,2,4]triazolo[1,5-c] pyrimidin-11(10H)-one derivatives were synthesised by the reactions of triethyl orthoformate or aromatic aldehydes with chromeno[2,3-d]pyrimidine derivatives, which were prepared by
- Wang, Zhong-Xia,Lia, Bei,Xing, Zheng,Chen, Li-Zhuang,Han, Guang-Fan
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p. 480 - 485
(2014/11/07)
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- Design, synthesis, docking study and biological evaluation of some novel tetrahydrochromeno [3′,4′:5,6]pyrano[2,3-b]quinolin-6(7H)-one derivatives against acetyl- and butyrylcholinesterase
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Novel hybrid derivatives of two known scaffolds; tetrahydroaminoquinoline and coumarin were synthesized and evaluated for both acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities. By means of an efficient nanocatalyst, the reaction time for the syntheses of the target compounds was reduced. Subsequently, Ellman's modified method was used to evaluate the enzyme inhibitory activity of the synthesized structures. It was observed that most hybrid structures were moderate to potent inhibitors of AChE compared to Tacrine as the reference drug among which 7f with 4-fluorophenyl substituent was the most active compound (IC50 = 5 nM).
- Khoobi, Mehdi,Alipour, Masoumeh,Moradi, Alireza,Sakhteman, Amirhossein,Nadri, Hamid,Razavi, Seyyede Faeze,Ghandi, Mehdi,Foroumadi, Alireza,Shafiee, Abbas
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p. 291 - 300
(2013/10/01)
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- One-step method for the synthesis of aryl olefins from aryl aldehydes and aliphatic aldehydes
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A conceptually new one-step reaction affording unexpected aryl olefinic product from aromatic aldehyde, aliphatic aldehyde and malononitrile in the presence of acetic acid-ammonium acetate under mild reaction conditions without using any metal catalyst is reported. This novel reaction was used to prepare a number of substituted aryl olefins including new molecules.
- Borate, Hanumant B.,Gaikwad, Supriya H.,Kudale, Ananada S.,Chavan, Subhash P.,Pharande, Shrikant G.,Wagh, Vitthal D.,Sawant, Vikram S.
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supporting information
p. 1528 - 1530
(2013/03/28)
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- Sodium benzoate as a green, efficient, and recyclable catalyst for knoevenagel condensation
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Sodium benzoate was utilized as a novel efficient and green catalyst for the Knoevenagel condensation of aldehydes with active methylene compounds such as ethyl cyanoacetate and malononitrile to afford substituted olefins through the conventional stirring
- Liu, Qing,Ai, Hong-Mei
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experimental part
p. 3004 - 3010
(2012/07/27)
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- Simple, efficient, and green method for synthesis of trisubstituted electrophilic alkenes using lipase as a biocatalyst
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A simple and efficient Knoevenagel condensation method for the synthesis of trisubstituted electrophilic alkenes was developed using lipase as a biocatalyst. Knoevenagel condensation was performed using the conventional method and using lipases (Aspergillus oryzae or Rhizopus oryzae) as biocatalysts, and reaction time, reaction temperature, yield, and recyclability were compared. Using a lipase as a biocatalyst eliminated the need for bases such as piperidine and pyridine. A wide range of aromatic aldehydes and ketones readily undergo condensation with active methylene compounds. The workup procedure is also very simple, and yields of the reactions are in the range of 75%to 95%. Both the biocatalysts were effectively recycled four times with no major decrease in the yield of product. The remarkable catalytic activity and reusability of lipase widens its applicability in Knoevenagel condensation with good to excellent yields for synthesis of trisubstituted electrophilic alkenes.Copyright Taylor & Francis Group, LLC.
- Borse, Bhushan Nanasaheb,Shukla, Sanjeev Ramchandra,Sonawane, Yogesh Ashok
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experimental part
p. 412 - 423
(2011/11/12)
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- Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
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Dipeptidyl peptidase IV (DPP-4) inhibitors have been shown to enhance GLP-1 levels and thereby improve hyperglycemia in type II diabetes. From a small fragment hit, using structure-based design, we have discovered a new class of non-covalent, potent and s
- Lam, Betty,Skene, Robert J.,Zhang, Zhiyuan,Stafford, Jeffery A.,Shi, Lihong,Gwaltney II, Stephen L.
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p. 6628 - 6631,4
(2012/12/12)
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- Knoevenagel condensation catalyzed by sodium silicate under solvent-free conditions
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Sodium silicate pentahydrate has been utilized as an efficient catalyst for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds to afford substituted olefins in yields of 80.6%～98.9% under solvent-free conditions at room tem
- Liu, Qing,Han, Yinfeng
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experimental part
p. 2033 - 2037
(2011/11/30)
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- Crown ether complex cation ionic liquids: Preparation and applications in organic reactions
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A series of crown ether complex cation ionic liquids (CECILs) were designed, synthesised and characterised by NMR spectroscopy, HRMS, thermogravimetric differential thermal analysis (TG-DTA) and elemental analysis. Their applications in various organic reactions were investigated: [15-C-5Na][OH], [15-C-5Na][OAc], [18-C-6K][OH] and [18-C-6K][OAc] (15-C-5=[15]crown-5; 18-C-6=[18]crown-6) efficiently catalysed the Michael addition of alkenes and relevant nucleophiles; [18-C-6K][OH] and [15-C-5Na][OH] effectively catalysed the Henry reaction of nitromethane and aromatic aldehydes; [18-C-6K][OH] has excellent catalytic efficiency for Knoevenagel condensation of aromatic aldehydes and malononitrile; PdCl2/[18-C-6K] 3[PO4]/K2CO3 efficaciously catalysed the Heck reaction of olefins and aromatic halides; [18-C-6K][BrO3] can be used as both oxidant and solvent in the oxidation reaction of aromatic alcohols. The CECIL catalysts [15-C-5Na][OH] (Michael addition) and [18-C-6K][OH] (Henry reaction) can be recycled and reused several times without obvious loss of activity and their recovery is very simple.
- Song, Yingying,Jing, Huanwang,Li, Bo,Bai, Dongsheng
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experimental part
p. 8731 - 8738
(2011/09/16)
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- Domino Knoevenagel condensation, Michael addition, and cyclization using ionic liquid, 2-hydroxyethylammonium formate, as a recoverable catalyst
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The Knoevenagel condensation reaction of aromatic aldehydes with malononitrile or dimedone was investigated. Also, the three-component and one-pot synthesis of 2-amino-5-oxo-4-aryl-4,5-dihydropyrano[3,2-cchromene-3- carbonitrile derivatives by condensing
- Shaterian,Arman,Rigi
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experimental part
p. 145 - 150
(2012/02/03)
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- An efficient, simple and green Zn(Phen)2Cl2 complex catalyzed synthesis of 4-H-Benzo[b]pyrans in water at ambient temperature
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An efficient method for the synthesis of 4-H-benzo[b]pyrans has been developed by the use of Zn(Phen)2Cl2 (2 mol%) as an ecofriendly catalyst. The mixture of an appropriate aldehyde, malononitrile and dimedone in the presence of the
- Mosaddegh,Hassankhani,Mansouri
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experimental part
p. 529 - 534
(2012/02/15)
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- RENIN INHIBITORS
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The invention provides compounds, pharmaceutical compositions, kits, method of preparing, and method of using the compounds which exhibit renin and other S9 proteases activities and consist of the formula:—wherein the variables are as defined herein.
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Page/Page column 39-40
(2010/06/16)
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- One-pot synthesis of polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety
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Polyfunctionalized 4H-pyran derivatives bearing fluorochloro pyridyl moiety were readily prepared in high yields via one-pot multicomponent reaction catalyzed by piperidine. This present protocol provides an efficient synthetic route to the target compoun
- Ye, Zhenjun,Xu, Renbo,Shao, Xusheng,Xu, Xiaoyong,Li, Zhong
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experimental part
p. 4991 - 4994
(2011/02/21)
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- Design, multicomponent synthesis, and bioactivities of novel neonicotinoid analogues with 1,4-dihydropyridine scaffold
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Novel neonicotinoid analogues bearing a 1,4-dihydropridine scaffold were designed and synthesized by multicomponent reactions (MCRs) to enhance π-π stacking. The synthesized compounds were identified by 1H NMR, 13C NMR, high-resoluti
- Zhang, Wenwen,Yang, Xiaobao,Chen, Weidong,Xu, Xiaoyong,Li, Lu,Zhai, Hongbin,Li, Zhong
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experimental part
p. 2741 - 2745
(2011/07/31)
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- Designing tetrahydroimidazo[1,2- a ]pyridine derivatives via catalyst-free Aza-Diels-Alder Reaction (ADAR) and their insecticidal evaluation
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A series of tetrahydroimidazo[1,2-a]pyridine derivatives were synthesized by the reaction of 2-vinyl-4,5-dihydroimidazole derivatives with substituted benzylidenemalononitrile via a catalyst-free aza-Diels-Alder reaction. Insecticidal activities of target
- Zhang, Wenwen,Chen, Yinbo,Chen, Weidong,Liu, Zewen,Li, Zhong
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scheme or table
p. 6296 - 6299
(2011/08/05)
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