- Controllable access to multi-substituted imidazoles: Via palladium(II)-catalyzed C-C coupling and C-N condensation cascade reactions
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A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles via cascade palladium catalyzed C-C coupling followed by intramolecular C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield.
- Yu, Haihua,Xiao, Li,Yang, Xicheng,Shao, Liming
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supporting information
p. 9745 - 9748
(2017/09/07)
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- 1-Cyanoformamidines. Formation during the RuO4-mediated oxidation of secondary amines
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When performed in the presence of cyanide and at pH smaller than 5, the RuO4-mediated oxidation of secondary amines Bn-NH-R (1a-b; R=Me, Et) gave mainly 1-cyanoformamidines Bn-NR-C(=NH)-CN (2a-b) and their hydrolysis products Bn-NR-COCN (3a-b), Bn-NR-CN (4a-b), Bn-NR-CONH2 (5a-b). Carboxamides 5a-b can result also directly from 1a-b. (Chemical Equation Presented).
- Florea, Cristina,Stavarache, Cristina,Petride, Horia
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p. 319 - 325
(2016/10/11)
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- RuO4-mediated oxidation of secondary amines. Part 1. Are hydroxylamines the main intermediates?
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The RuO4-catalyzed oxidation of secondary amines Bn-NH-CH2R (1a and b; R=H, Me) gave mainly amides, but minute amounts of nitrones PhCH=N(O)-CH2R (9a and b) and traces of Bn-N(OH)-CH2R (R=H, 4a) were also detect
- Florea, Cristina A.,Petride, Horia
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p. 475 - 486
(2016/07/20)
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- Design and synthesis of novel type VI-like β-turn mimetics. Diversity at the i+1 and the i+2 position
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In this paper, a synthetic approach for functionalised 5-aminopiperidinone- 2-carboxylate (APC) systems as non-pro cis-peptide bond containing external β-turn mimics is presented. The scope and limitations of the synthetic method are discussed and the pot
- De Borggraeve, Wim M.,Verbist, Bie M.P.,Rombouts, Frederik J.R.,Pawar, Vijaykumar G.,Smets, Wim J.,Kamoune, Laila,Alen, Jo,Van Der Eycken, Erik V.,Compernolle, Frans,Hoornaert, Georges J.
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p. 11597 - 11612
(2007/10/03)
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- A new entry to [1,2,4]triazolo[1,5-α][1,4]benzodiazepin-6-ones via intramolecular nitrilimine cycloaddition to the cyano group
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A series of [1,2,4]triazolo[1,5-α][1,4]benzodiazepin-6-ones of potential pharmacological interest have been synthesised by means of intramolecular nitrilimine cycloadditions to the cyano group.
- Broggini, Gianluigi,Garanti, Luisa,Molteni, Giorgio,Zecchi, Gaetano
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p. 14859 - 14868
(2007/10/03)
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