303121-08-6

Basic information

• Product Name: AURORA 17941
• Synonyms: AURORA 17941;6-ETHOXY-4-HYDROXYQUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER;BUTTPARK 160\40-11;ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate
• CAS NO: 303121-08-6
• Molecular Formula: C14H15NO4
• Molecular Weight: 261.27
• Mol File: 303121-08-6.mol

Chemical Properties

• Melting Point: 261-262 °C(Solv: ethanol (64-17-5))
• Boiling Point: 406°C at 760 mmHg
• Flash Point: 199.3°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 8.43E-07mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 2.75±0.50(Predicted)
• CAS DataBase Reference: AURORA 17941(CAS DataBase Reference)
• NIST Chemistry Reference: AURORA 17941(303121-08-6)
• EPA Substance Registry System: AURORA 17941(303121-08-6)

Safety Data

• Hazardous Substances Data: 303121-08-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H15NO4/c1-3-18-9-5-6-12-10(7-9)13(16)11(8-15-12)14(17)19-4-2/h5-8H,3-4H2,1-2H3,(H,15,16)

Upstream product

• 156-43-4 4-Ethoxyaniline 
• 103976-28-9 2-(4-ethoxy-anilinomethylene)-propanedioic acid diethyl ester 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 1242260-42-9 ethyl 4-amino-6-ethoxyquinoline-3-carboxylate 
• 1242260-54-3 4-amino-6-ethoxyquinoline-3-carboxylic acid 
• 112190-03-1 ethyl 4-chloro-6-ethoxyquinoline-3-carboxylate 
• 303121-10-0 6-ethoxy-4-hydroxy-quinoline-3-carboxylic acid 

Relevant articles and documents

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER

The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER

The present invention includes methods of stabilizing one or more sweet enhancers when they are exposed to a light source as well as liquid compositions containing one or more sweet enhancers and one or more photostabilizers.

SWEET FLAVOR MODIFIER

The present invention includes compounds having structural formula (I), or pharmaceutically acceptable salts, solvate, and/or ester thereof. These compounds are useful as sweet flavor modifiers. The present invention also includes compositions comprising the present compounds and methods of enhancing the sweet taste of ingestible compositions. Furthermore, the present invention provides methods for preparing the compounds.

Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2

Due to the emerging role of protein kinase CK2 as a molecule that participates not only in the development of some cancers but also in viral infections and inflammatory failures, small organic inhibitors of CK2, besides application in scientific research, may have therapeutic significance. In this paper, we present a new class of CK2 inhibitors-3-carboxy-4(1H)-quinolones. This class of inhibitors has been selected via receptor-based virtual screening of the Otava compound library. It was revealed that the most active compounds, 5,6,8-trichloro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (7) (IC 50 = 0.3 μM) and 4-oxo-1,4-dihydrobenzo[h]quinoline-3-carboxylic acid (9) (IC50 = 1 μM), are ATP competitive (Ki values are 0.06 and 0.28 μM, respectively). Evaluation of the inhibitors on seven protein kinases shows considerable selectivity toward CK2. According to theoretical calculations and experimental data, a structural model describing the key features of 3-carboxy-4(1H)-quinolones responsible for tight binding to CK2 active site has been developed.