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2-CHLORO-6-(4-METHOXYPHENYL)NICOTINONITRILE is a chemical compound with the molecular formula C13H9ClN2O. It is a nitrile derivative of nicotinonitrile, characterized by its chloro and methoxy functional groups attached to a nicotinonitrile core. This versatile molecule is commonly used as a building block in the synthesis of various pharmaceutical and agrochemical compounds, making it a promising intermediate for the manufacturing of active pharmaceutical ingredients and other organic compounds.

306977-91-3

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306977-91-3 Usage

Uses

Used in Pharmaceutical Industry:
2-CHLORO-6-(4-METHOXYPHENYL)NICOTINONITRILE is used as a building block for the synthesis of various pharmaceutical compounds. Its chloro and methoxy functional groups make it a versatile molecule for various chemical reactions and transformations, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
2-CHLORO-6-(4-METHOXYPHENYL)NICOTINONITRILE is also used as a building block in the synthesis of agrochemical compounds. Its unique structure and functional groups allow for the creation of new agrochemicals with potential applications in crop protection and pest control.
Used in Organic Chemistry Research:
2-CHLORO-6-(4-METHOXYPHENYL)NICOTINONITRILE is used as a research compound in organic chemistry. Its potential biological and medicinal properties make it an interesting subject for further study, with the aim of understanding its pharmacological significance and exploring its potential applications in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 306977-91-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,0,6,9,7 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 306977-91:
(8*3)+(7*0)+(6*6)+(5*9)+(4*7)+(3*7)+(2*9)+(1*1)=173
173 % 10 = 3
So 306977-91-3 is a valid CAS Registry Number.
InChI:InChI=1/C13H9ClN2O/c1-17-11-5-2-9(3-6-11)12-7-4-10(8-15)13(14)16-12/h2-7H,1H3

306977-91-3 Well-known Company Product Price

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  • Alfa Aesar

  • (H50520)  2-Chloro-3-cyano-6-(4-methoxyphenyl)pyridine, 98%   

  • 306977-91-3

  • 250mg

  • 474.0CNY

  • Detail
  • Alfa Aesar

  • (H50520)  2-Chloro-3-cyano-6-(4-methoxyphenyl)pyridine, 98%   

  • 306977-91-3

  • 1g

  • 1894.0CNY

  • Detail

306977-91-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-chloro-6-(4-methoxyphenyl)pyridine-3-carbonitrile

1.2 Other means of identification

Product number -
Other names 2-Chloro-6-(4-methoxyphenyl)nicotinonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:306977-91-3 SDS

306977-91-3Relevant articles and documents

A facile method for the synthesis of nicotinonitriles from ketones via a one-pot chloromethyleneiminium salt mediated three-component reaction

Asokan,Anabha,Thomas, Ajith Dain,Jose, Ann Maria,Lethesh,Prasanth,Krishanraj

, p. 5641 - 5643 (2007)

Simple enolizable ketones such as acetophenones and benzalacetones were treated with malononitrile under Vilsmeier-Haack reaction conditions to afford 2-chloronicotinonitriles. The reaction proceeds via a one-pot chloromethyleneiminium salt mediated three

Design, synthesis and biological evaluation of novel indazole-based derivatives as potent HDAC inhibitors via fragment-based virtual screening

Gao, Liang,Gao, Lina,He, Fengjun,Hu, Lihong,Kang, Di,Liu, Jian,Wang, Ping,Wen, Yu,Zhou, Jingxian

, (2020/03/10)

Based on fragment-based virtual screening and bioisoterism strategies, novel indazole and pyrazolo[3,4-b] pyridine derivatives as HDACs inhibitors were designed, synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDACs, especially compounds 15k and 15m were identified as potent inhibitors of HDAC1 (IC50 = 2.7 nM and IC50 = 3.1 nM), HDAC2 (IC50 = 4.2 nM and IC50 = 3.6 nM) and HDAC8 (IC50 = 3.6 nM and IC50 = 3.3 nM). Further anti-proliferation assays revealed that compounds 15k and 15m showed better anti-proliferative activities against HCT-116 and HeLa cells than positive control SAHA. The western blot analysis results indicated that compounds 15k and 15m noticeably up-regulated the level of acetylated α-tubulin and histone H3. In addition, the two compounds 15k and 15m could arrest cell cycle in G2/M phase and promote cell apoptosis, which was similar as the reference compound SAHA. Through the molecular docking and dynamic studies, the potent HDAC inhibitory activities mainly caused by van der Waals and electrostatic interactions with the HDACs.

INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 AND TDO) AND THEIR USE IN THERAPY

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Page/Page column 56; 57; 58, (2016/02/29)

Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-ox

6-Aryl-pyrazolo[3,4-b]pyridines: Potent inhibitors of glycogen synthase kinase-3 (GSK-3)

Witherington, Jason,Bordas, Vincent,Gaiba, Alessandra,Garton, Neil S.,Naylor, Antoinette,Rawlings, Anthony D.,Slingsby, Brian P.,Smith, David G.,Takle, Andrew K.,Ward, Robert W.

, p. 3055 - 3057 (2007/10/03)

A novel series of 6-aryl-pyrazolo[3,4-b]pyridines has been identified that are potent inhibitors of glycogen synthase kinase-3 (GSK-3).

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