308298-47-7

Basic information

• Product Name: 3-METHYL-5-[(4-METHYLPHENYL)SULFANYL]-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• Synonyms: 3-METHYL-5-[(4-METHYLPHENYL)SULFANYL]-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE
• CAS NO: 308298-47-7
• Molecular Formula: C₁₈H₁₆N₂OS
• Molecular Weight: 308.4
• Mol File: 308298-47-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-METHYL-5-[(4-METHYLPHENYL)SULFANYL]-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-5-[(4-METHYLPHENYL)SULFANYL]-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(308298-47-7)
• EPA Substance Registry System: 3-METHYL-5-[(4-METHYLPHENYL)SULFANYL]-1-PHENYL-1H-PYRAZOLE-4-CARBALDEHYDE(308298-47-7)

Safety Data

• Hazardous Substances Data: 308298-47-7(Hazardous Substances Data)

Upstream product

• 947-95-5 5-chloro-4-formyl-3-methyl-1-phenyl-1H-pyrazole 
• 106-45-6 para-thiocresol 
• 89-25-8 edaravone 

Downstream Products

• 908287-69-4 C₁₈H₁₇N₃OS 

Relevant articles and documents

One-Pot Multiсomponent Synthesis and Characterization of Some New Pyrazolylpyrazoline Scaffolds as Antitubercular and Antimalarial Agents

Abstract: A new, facile, and environment friendly synthesis of some novel pyrazolylpyrazoline derivatives has been achieved using one-pot multicomponent reaction of substituted aromatic aldehydes, 2-acetylpyrrole or 2-acetyl-1,3-thiazole, and substituted hydrazines in the presence of sodium hydroxide in ethanol at room temperature under ultrasonication. The salient features of this green protocol are one-pot reaction, short reaction time, and straightforward workup procedure. All synthesized compounds were characterized by spectroscopic techniques, and their in vitro antitubercular and antimalarial activities were evaluated. Some of the compounds tested showed good to excellent activity compared to standard drugs.

Synthesis and Molecular Docking Study of Arylsulfanyl Pyrazolylpyrazoline Derivatives as Antitubercular Agents

Abstract: New arylsulfanyl pyrazolylpyrazoline derivatives were synthesized via a facile protocol, and their structure was confirmed by FT-IR, 1H and 13C NMR, and mass spectra. Some of the synthesized compounds exhibited remarkable in vitro antitubercular activity. Molecular docking study provided well-clustered solutions to the mode of binding and affinity of these molecules to the active site of MTB enoyl–acyl carrier protein reductase (InhA).

Synthesis, characterization, in silico molecular docking study and biological evaluation of a 5-(phenylthio) pyrazole based polyhydroquinoline core moiety

A multicomponent cyclocondensation reaction has been developed by incorporating 3-methyl-5-substituted phenylthio-1-phenyl-1H-pyrazole-4-carbaldehydes 3a-c, various enaminones 6a-c and different active methylene compounds 7a-c (malononitrile 7a/ethylcayno

Green method for the synthesis of chromeno[2,3- C ]pyrazol-4(1 H)-ones through ionic liquid promoted directed annulation of 5-(aryloxy)-1 H -pyrazole-4-carbaldehydes in aqueous media

The first classical heterocyclic ionic liquid (IL) promoted C-H bond oxidant cross-coupling reaction for the intramolecular annulation of 5-(aryloxy)-1H-pyrazole-4-carbaldehydes to chromeno[2,3-c]pyrazol-4(1H)-ones has been disclosed. The promoter 1,3-dibutyl-1H-benzo[d][1,2,3]triazol-3-ium bromide can be easily recycled and reused with the same efficacies for at least five cycles in aqueous medium. The strategy works smoothly and provides an applicable protocol to construct a wide range of products.

Synthesis and antiviral activities of pyrazole derivatives containing an oxime moiety

Target compounds 4a-n were obtained by the reaction of 1 -substituted phenyl-3-methyl-5-substituted phenylthio-4-pyrazolaldoximes (3) with chloromethylated heterocyclic compounds (CICH2-R3) under reflux conditions in ethanol. Subsequ