- Palladium-catalyzed intermolecular C(sp3)-H amidation
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Dual capacity: A new palladium-catalyzed intermolecular sequence consisting of the C-H activation and amidation of methyl groups relies on N-fluorobis(phenylsulfonyl)imide (NFSI) as both the oxidant and the nitrogen source. The reaction provides the corresponding arylamines as bissulfonimides along with HF as the only by-product. Both experimental and computational results suggest the involvement of a monomeric palladium(IV) intermediate. Copyright
- Iglesias, Alvaro,Alvarez, Rosana,De-Lera, Angel R.,Muniz, Kilian
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supporting information; experimental part
p. 2225 - 2228
(2012/04/10)
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- ARYL IMIDAZOLE COMPOUNDS AND THEIR USE AS BETA AMYLOID PRODUCTION INHIBITORS
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A compound represented by the formula (I): or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a triazolyl group or the like which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
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Page/Page column 74-75
(2010/09/17)
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