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(2,5-dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 312513-29-4 Structure
  • Basic information

    1. Product Name: (2,5-dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone
    2. Synonyms: (2,5-dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone
    3. CAS NO:312513-29-4
    4. Molecular Formula: C15H10O5
    5. Molecular Weight: 270.24
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 312513-29-4.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2,5-dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2,5-dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone(312513-29-4)
    11. EPA Substance Registry System: (2,5-dihydroxyphenyl)(5-hydroxy-1-benzofuran-3-yl)methanone(312513-29-4)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 312513-29-4(Hazardous Substances Data)

312513-29-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 312513-29-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,2,5,1 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 312513-29:
(8*3)+(7*1)+(6*2)+(5*5)+(4*1)+(3*3)+(2*2)+(1*9)=94
94 % 10 = 4
So 312513-29-4 is a valid CAS Registry Number.

312513-29-4Downstream Products

312513-29-4Relevant articles and documents

Synthesis of isoflavones by tandem demethylation and ring-opening/cyclization of methoxybenzoylbenzofurans

Kunyane, Phaladi,Sonopo, Molahlehi S.,Selepe, Mamoalosi A.

, p. 3074 - 3082 (2019/11/19)

The unexpected conversion of benzoylbenzofurans into isoflavones through an intramolecular cascade that involves deprotection and ring-opening/cyclization is described. This was discovered in an investigation of the possible transformation of benzoylbenzofurans into coumaronochromones. This route affords isoflavones in two major steps from acetophenones and benzoquinones. The transformation was validated by synthesizing differently substituted isoflavone derivatives and further applied to a concise synthesis of a potential anticancer lead compound, glaziovianin A (1).

Identification of benzofuran-3-yl(phenyl)methanones as novel SIRT1 inhibitors: Binding mode, inhibitory mechanism and biological action

Wu, Jiahui,Li, Yi,Chen, Kaixian,Jiang, Hualiang,Xu, Ming-Hua,Liu, Dongxiang

, p. 441 - 450 (2013/03/29)

SIRT1 is a NAD+-dependent deacetylase. Here we described new SIRT1 inhibitors with the scaffold of benzofuran-3-yl(phenyl)methanone. The inhibitors were predicted to bind in C-pocket of SIRT1, forming hydrophobic interactions with Phe273, Phe312 and Ile347. Introducing hydroxyl to meta position of phenyl may form H-bond with Asn346. Indeed, (2,5-dihydroxyphenyl)(5- hydroxy-1-benzofuran-3-yl)methanone (16), an analogue with hydroxyls at ortho and meta positions, showed greater inhibition. The binding mode was validated by structural modifications and kinetic studies. Since C-pocket is the site where the nicotinamide moiety of NAD+ binds and the hydrolysis takes place, binding of 16 in C-pocket would block the transformation of NAD+ to productive conformation and hence inhibit the deacetylase activity. Consistently, 16 inhibited SIRT1 through up-regulating p53 acetylation on cellular level.

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