314-41-0

Basic information

• Product Name: 2,3,4,6-TETRAFLUORONITROBENZENE
• Synonyms: 1,2,3,5-Tetrafluoro-4-nitrobenzene;Benzene, 1,2,3,5-tetrafluoro-4-nitro-;2,3,4,6-TETRAFLUORONITROBENZENE;2,3,4,6-TETRAFLUORONITROBENZENE, 97+%;5-fluro-2-methylaniline;2,3,4,6-Tetrafluoronitrobenzene 98%;2,3,4,6-Tetrafluoronitrobenzene98%;1-Nitro-2,3,4,6-tetrafluorobenzene
• CAS NO: 314-41-0
• Molecular Formula: C₆HF₄NO₂
• Molecular Weight: 195.07
• EINECS: 206-246-7
• Product Categories: Benzene series;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 314-41-0.mol

Chemical Properties

• Melting Point: -5
• Boiling Point: 78-79°C 20mm
• Flash Point: 160 °F
• Appearance: yellow liquid
• Density: 1.511 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.007mmHg at 25°C
• Refractive Index: n20/D 1.464(lit.)
• Storage Temp.: 2-8°C
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases. Combustible.
• CAS DataBase Reference: 2,3,4,6-TETRAFLUORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,4,6-TETRAFLUORONITROBENZENE(314-41-0)
• EPA Substance Registry System: 2,3,4,6-TETRAFLUORONITROBENZENE(314-41-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 314-41-0(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2,3,4,6-TETRAFLUORONITROBENZENE is used as a chemical intermediate for the synthesis of various compounds due to its reactive nature and ability to undergo palladium-catalyzed cross-coupling reactions with alkyne derivatives.
Used in Pest Control:
2,3,4,6-TETRAFLUORONITROBENZENE is used as a molluscicide for the control of Biomphalaria glabrata, a snail species that serves as an intermediate host for the parasitic flatworm Schistosoma mansoni, which causes schistosomiasis in humans.
Used in Pharmaceutical Industry:
2,3,4,6-TETRAFLUORONITROBENZENE is used as a starting material for the development of new pharmaceutical compounds, given its unique chemical properties and potential for further reactions and modifications.

InChI:InChI=1/C8H7FO2/c1-5-3-2-4-6(7(5)9)8(10)11/h2-4H,1H3,(H,10,11)

Upstream product

• 2367-82-0 1,2,3,5-tetrafluorobenzene 

Downstream Products

• 765962-71-8 (2-fluoro-4-iodo-phenyl)-(2,3,5-trifluoro-6-nitro-phenyl)-amine 
• 20002-14-6 2,4,5,6-Tetrafluoro-1,3-dinitrobenzene 
• 923294-22-8 3-iodo-2,4,5,6-tetrafluoroaniline 
• 923294-26-2 3-iodo-2,4,5,6-tetrafluoroazidobenzene 
• 923294-32-0 2,4,5,6-tetrafluoro-3-iodophenylnitrene 
• 148927-13-3 3,4,6-trifluoro-2-(4-methyl-1-piperazinyl)-nitrobenzene 
• 363-73-5 2,3,4,6-tetrafluoroaniline 
• 5415-62-3 2,3,5-trifluoro-6-nitroaniline 
• 71451-49-5 1,2,3,5-tetrafluoro-4-iodo-6-nitrobenzene 
• 17826-68-5 1-bromo-2,3,4,6-tetrafluoro-5-nitrobenzene 
• 66684-67-1 1,3,4-trifluoro-5-methoxy-2-nitrobenzene 

Relevant articles and documents

HETEROCYCLIC SULFONAMIDE DERIVATIVES

The present invention relates to compounds: and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

HETEROCYCLIC SULFONAMIDE DERIVATIVES

The present invention relates to compounds (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

Chemistry of superacids: 35. * NO2Cl-3MXN systems: Superelectrophilic aprotic nitrating agents for deactivated aromatics

Superelectrophilic nitration of deactivated aromatics with NO2Cl-3MXn complexes in aprotic nonpolar solvents such as CH2Cl2 makes it possible to obtain the corresponding nitro derivatives in good to almost quantitative yields under mild conditions.

Nitration of Strongly Deactivated Aromatics with Superacidic Mixed Nitric-Triflatoboric Acid (HNO3/2CF3SO3H-B(O3SCF3)3)

The nitration of various deactivated arenes (including methanesulfonyl-, nitro-, and polyhalobenzenes) was carried out in good yield with mixed nitric-triflatoboric superacid.For example pentafluorobenzene gave pentafluoronitrobenzene in 99percent yield, nitrobenzene to m-dinitrobenzene in 92percent selectivity with 85percent overall yield, and methyl phenyl sulfone gave only the m-nitro isomer in 78percent isolated yield.Thus the new nitrating system gives high regioselectivity and yields under generally mild reaction conditions.The reagent system is compatible with many functional groups of arenes.