31519-50-3

Basic information

• Product Name: (S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE
• Synonyms: (S)-butan-2-amine hydrochloride;(S)-SEC-BUTYLAMINE HCL;2-Butanamine, hydrochloride, (2S)-
• CAS NO: 31519-50-3
• Molecular Formula: C₄H₁₂N*Cl
• Molecular Weight: 109.6
• Mol File: 31519-50-3.mol

Chemical Properties

• Melting Point: 106-107 °C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE(31519-50-3)
• EPA Substance Registry System: (S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE(31519-50-3)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 31519-50-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE is used as an intermediate for the synthesis of various pharmaceuticals due to its ability to selectively react with different functional groups, contributing to the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, (S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE is utilized as a building block for the production of agrochemicals, playing a role in the development of pesticides and other agricultural chemicals.
Used in Organic Chemical Synthesis:
(S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE is used as a versatile intermediate in organic chemical synthesis, enabling the creation of a wide range of organic compounds for various applications.
Used in Rubber Chemical Production:
(S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE is used in the production of rubber chemicals, contributing to the development of materials with specific properties for use in the rubber industry.
Used in Corrosion Inhibitor Production:
(S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE is employed in the synthesis of corrosion inhibitors, helping to develop products that protect metals from corrosion and extend their lifespan.
Used in Surfactant Production:
It is also used in the production of surfactants, which are essential in various industries for their properties to reduce surface tension and stabilize emulsions.
Used in Neurodegenerative Disease Treatment Research:
(S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE has been studied for its potential applications in the treatment of neurodegenerative diseases, indicating its possible use as a therapeutic agent in medical research.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
In the field of asymmetric synthesis, (S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE is used as a chiral auxiliary, playing a crucial role in the production of enantiomerically pure compounds, which are essential in pharmaceutical development.
It is important to handle (S)-(-)-SEC-BUTYLAMINE HYDROCHLORIDE with care, as it can be toxic and hazardous if not properly managed.

Upstream product

• 102095-57-8 C₁₃H₂₈NO₅P 
• 2719-08-6 methyl 2-(acetylamino)benzoate 
• 142310-24-5 1-<(1-methylpropylidene)amino>-3-phenyl-4-methyl-5-methoxypyrazole 
• 76716-18-2 diphenylphosphinic 1-methylpropylamide 
• 146039-14-7 sec-Butyl-phosphorimidic acid triethyl ester 

Downstream Products

• 513-49-5 (S)-2-aminobutane 
• 640-68-6 D-Val-OH 
• 78-93-3 butanone 
• 673-06-3 D-(R)-phenylalanine 
• 556-02-5 tyrosine 
• 427878-18-0 N-(S)-sec-butyl-4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 
• 623154-17-6 N-(S)-sec-butyl-4-[(2-methyl-5-ethylcarbamoyl)aminophenyl]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide 
• 64343-40-4 (S,S)-trans-1,2-diaminocyclohexane⁽²⁺⁾ 
• 623-45-0 (S)-Butyl-⁽²⁾-isothiocyanat 
• 31458-26-1 N-sec-Butyl-3,3,3-trifluoro-2-methoxy-2-phenyl-propionamide 
• 81038-91-7 3-sec-butylamino-1,2-benzisothiazole-1,1-dioxide 
• 83325-08-0 1,7-dihydro-2-methyl-1-(1-methylpropyl)-7-phenyl-6H-purin-6-one 
• 86217-79-0 sec-butyl isocyanate 

Relevant articles and documents

Hydrogenolysis of 1-Aminopyrazoles: Synthesis of Primary and Secondary Alkylamines

The tautomerizable N-aminopyrazolone 9, the O-methyl 1 and N-methyl derivatives 4 were condensed with carbonyl compounds to give the alkenylaminopyrazoles 12, 2a-g and 5c, wich, under mild conditions, were hydrogenated to the corresponding alkylamino derivatives.The subesquent hydrogenation of the latter ones gave different results according to the structure of the starting material.The 5-methoxy-1-alkylaminopyrazoles 3a-g yielded the 5-methoxypyrazole 15 and the corresponding primary amines in good yields.On the contrary, N-methyl-1-alkylaminopyrazolone-5 6c gave 1-a lkylpyrazolone-3 8.

Optimized procedures for one-pot conversion of alkyl bromides into amines via the Staudinger reaction

New optimized procedures for transforming primary and secondary alkyl bromides into the corresponding primary amine salts have been elaborated. Essential modifications of azidation and deprotection of intermediate triethoxyphosphine alkylimides resulted in substantial improvement of the overall yields. Conversion of ammonium tosylates and hydrochlorides into free amines in a nonaqueous medium is described.

Conversion of Alcohols into Primary Amines, a New Mitsunobu Version of Gabriel-type Synthesis

Primaere und sekundaere Alkohole liefern die entsprechenden Amin-hydrochloride 3 mit guten Ausbeuten (60-85percent), wenn sie unter milden Bedingungen mit N-(Diethoxyphosphoryl)-carbamidsaeure-tert-butylester (1) in Gegenwart von Azodicarbonsaeure-diethylester/Triphenylphosphan umgesetzt und danach die entstandenen N-Alkyl-N-(diethoxyphosphoryl)carbamidsaeureester 2 mit gasfoermigem HCl gespalten werden.Die Stereochemie dieser Reaktion wird untersucht.

Phosphoramides. XIII. Phosphorus Pentaoxide-Amine Hydrochloride Mixtures as Reagents in the Synthesis of 4(3H)-Quinazolinones and 4-Quinazolinamines

4(3H)-Quinazolinones 3a-r have been prepared by heating methyl N-acylanthranilates 1a-c and the hydrochlorides of primary aliphatic and aromatic amines with phosphorus pentaoxide and N,N-dimethylcyclohexylamine at 180 deg C. 4-Quinazolinamines 4 and the amidine 7 were isolated as by-products.The carboxamides 5 and 6 were believed to be reaction intermediates.By raising the temperature to 250 deg C 4 was obtained in a preparative yield.