31595-63-8

Basic information

• Product Name: 2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI)
• Synonyms: 2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI);3-HYDRAZONO-3,4-DIHYDROQUINOXALIN-2(1H)-ONE;2-quinoxalinol, 3-hydrazino-;3-hydrazinoquinoxalin-2-ol(SALTDATA: FREE);3-Hydrazinylquinoxalin-2-ol;3-hydrazino-1H-quinoxalin-2-one;3-hydrazinyl-1H-quinoxalin-2-one
• CAS NO: 31595-63-8
• Molecular Formula: C₈H₈N₄O
• Molecular Weight: 176.18
• Product Categories: PIPERIDINE
• Mol File: 31595-63-8.mol

Chemical Properties

• Melting Point: >300 °C
• Boiling Point: 458.8°C at 760 mmHg
• Flash Point: 231.3°C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 4.87E-09mmHg at 25°C
• Refractive Index: 1.758
• PKA: 9.84±0.20(Predicted)
• CAS DataBase Reference: 2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI)(31595-63-8)
• EPA Substance Registry System: 2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI)(31595-63-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 31595-63-8(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI) is used as a reactant in various chemical reactions for the synthesis of complex organic molecules. Its unique structure and properties make it suitable for use in the development of new compounds with potential applications in various fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI) is used as a key intermediate in the development of new drug compounds. Its versatile chemical properties allow for the creation of novel therapeutic agents with potential applications in treating various diseases and medical conditions.
Used in the Formation of Heterocyclic Compounds:
2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI) is also utilized as a reagent in the formation of various heterocyclic compounds. These heterocyclic compounds are important in the field of chemistry and have a wide range of applications, including as pharmaceuticals, agrochemicals, and dyes.
Overall, 2,3-Quinoxalinedione,1,4-dihydro-,monohydrazone(9CI) is a significant chemical compound with a broad range of applications in the fields of organic synthesis, pharmaceutical research, and the formation of heterocyclic compounds. Its potential for further exploration and development makes it a valuable resource for scientists and researchers in these areas.

InChI:InChI=1/C8H8N4O/c9-12-7-8(13)11-6-4-2-1-3-5(6)10-7/h1-4H,9H2,(H,10,12)(H,11,13)

Upstream product

• 30747-72-9 ethyl (3,4-dihydro-3-oxo-2-quinoxalinyl)phenyl acetate 
• 35015-91-9 3-amino-2(1H)-quinoxalinone 

Downstream Products

• 126802-30-0 C₁₆H₁₅N₅O₂ 
• 126802-35-5 C₁₅H₁₂FN₅O₂ 
• 126802-32-2 C₁₅H₁₂ClN₅O₂ 
• 126802-48-0 C₁₅H₁₂FN₅OS 
• 129227-33-4 4-(4-Methoxy-phenyl)-4-oxo-2-[(3-oxo-3,4-dihydro-quinoxalin-2-yl)-hydrazono]-butyric acid ethyl ester 
• 126802-49-1 C₁₆H₁₂F₃N₅OS 
• 129227-32-3 4-Oxo-2-[(3-oxo-3,4-dihydro-quinoxalin-2-yl)-hydrazono]-4-phenyl-butyric acid ethyl ester 
• 126802-43-5 C₁₈H₁₉N₅OS 
• 129227-27-6 3-{N'-[1-(4-Fluoro-phenyl)-meth-(E)-ylidene]-hydrazino}-1H-quinoxalin-2-one 
• 129227-26-5 3-{N'-[1-(4-Chloro-phenyl)-meth-(E)-ylidene]-hydrazino}-1H-quinoxalin-2-one 
• 126802-42-4 3-hydrazinoquinoxalin-2(1H)-one 
• 129227-31-2 1-(4-fluorophenyl)-[1,2,4]triazolo[4,3-a]quinoxalin-4(5H)-one 
• 126802-47-9 C₁₅H₁₂FN₅OS 
• 129227-25-4 3-{N'-[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-hydrazino}-1H-quinoxalin-2-one 

Relevant articles and documents

Part I: Synthesis, cancer chemopreventive activity and molecular docking study of novel quinoxaline derivatives

The reaction of o-phenylene diamine and ethyl oxamate is reinvestigated and led to 3-aminoquinoxalin-2(1H)-one rather than benzimidazole-2-carboxamide as was previously reported. The structure of the obtained quinoxaline has been confirmed by X-ray. The anti-tumor activity of synthesized quinoxalines 1-21 has been evaluated by studying their possible inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13- acetate (TPA). Among the studied compounds 1-21, compounds 12, 8, 13, 18, 17 and 19, respectively, demonstrated strong inhibitory effects on the EBV-EA activation without showing any cytotoxicity and their effects being stronger than that of a representative control, oleanolic acid. Furthermore, compound 12 exhibited a remarkable inhibitory effect on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter. The result of the present investigation indicated that compound 12 might be valuable as a potent cancer chemopreventive agent. Moreover, the molecular docking into PTK (PDB: 1t46) has been done for lead optimization of the aforementioned compounds as potential PTK inhibitors.

Ketimine-enamine Tautomers of Tetrazoloquinoxaline Derivatives

4-Ethoxycarbonylmethylene-4,5-dihydrotetrazoloquinoxaline and itsα-substituted derivative display ketimine-enamine tautomeric isomerism.Their IR spectra and hydrazinolysis of 3,4-dihydro-3-oxo-quinoxaline analogues and related substances were studied.