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2-Amino-1,3-benzenediol, also known as o-Amino-phenol, is an organic compound with the chemical formula C6H7NO2. It is a derivative of phenol and aniline, characterized by its aromatic amine and dihydroxy benzene structure. This white to light brown powder is commonly used in the production of pharmaceuticals, dyes, and photographic developers. Recognized for its potential antioxidant properties and its role in the synthesis of various important compounds in the pharmaceutical and chemical industries, 2-Amino-1,3-benzenediol also warrants attention due to its potential toxic effects in high doses, necessitating proper handling and safety precautions.

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  • 3163-15-3 Structure
  • Basic information

    1. Product Name: 2-Amino-1,3-benzenediol
    2. Synonyms: 2-Aminoresorcinol;2-amino-1,3-benzenediol;o-aminoresorcinol;6-BROMO-2,4-DIETHOXY-1-NITROBENZENE;2-aMinobenzene-1,3-diol;1,3-Benzenediol, 2-amino-
    3. CAS NO:3163-15-3
    4. Molecular Formula: C6H7NO2
    5. Molecular Weight: 125.12528
    6. EINECS: 1533716-785-6
    7. Product Categories: N/A
    8. Mol File: 3163-15-3.mol
  • Chemical Properties

    1. Melting Point: >200 °C (decomp)
    2. Boiling Point: 292.8 °C at 760 mmHg
    3. Flash Point: 130.9 °C
    4. Appearance: /
    5. Density: 1.412 g/cm3
    6. Refractive Index: 1.512
    7. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. PKA: 9.24±0.10(Predicted)
    10. CAS DataBase Reference: 2-Amino-1,3-benzenediol(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-Amino-1,3-benzenediol(3163-15-3)
    12. EPA Substance Registry System: 2-Amino-1,3-benzenediol(3163-15-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 3163-15-3(Hazardous Substances Data)

3163-15-3 Usage

Uses

Used in Pharmaceutical Industry:
2-Amino-1,3-benzenediol is used as a key intermediate in the synthesis of various pharmaceutical compounds for its versatile chemical properties, contributing to the development of new drugs and therapeutic agents.
Used in Dye Industry:
As a component in dye production, 2-Amino-1,3-benzenediol is utilized for its ability to form color compounds, playing a crucial role in the creation of a wide range of dyes used in different applications.
Used in Photographic Industry:
2-Amino-1,3-benzenediol is used as a chemical component in photographic developers, where its reactivity and reducing properties aid in the development process of photographic films and papers.
Used in Chemical Synthesis:
2-Amino-1,3-benzenediol is employed as a reagent in the synthesis of various organic and inorganic compounds, leveraging its unique chemical structure to facilitate reactions in the chemical industry.
Used in Antioxidant Research:
2-Amino-1,3-benzenediol is studied for its potential antioxidant properties, which may have applications in health and nutrition, as well as in industrial processes where oxidation can lead to degradation of materials or products.

Check Digit Verification of cas no

The CAS Registry Mumber 3163-15-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,1,6 and 3 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3163-15:
(6*3)+(5*1)+(4*6)+(3*3)+(2*1)+(1*5)=63
63 % 10 = 3
So 3163-15-3 is a valid CAS Registry Number.
InChI:InChI=1/C11H15BrO3/c1-4-14-8-6-9(12)11(13-3)10(7-8)15-5-2/h6-7H,4-5H2,1-3H3

3163-15-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-aminobenzene-1,3-diol

1.2 Other means of identification

Product number -
Other names 2-amino-benzene-1,3-diol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:3163-15-3 SDS

3163-15-3Relevant articles and documents

One-pot synthesis of hydroxybenzo[d]- oxazole-2-aliphatic acid derivatives by Meerwein's reagent

Zhang, Wei,Liu, Wenlu,Jiang, Xizhen,Jiang, Faqin,Fu, Lei

, p. 2772 - 2779 (2012)

(Chemical Equation Presented) A general one-pot synthesis of hydroxylbenzo[d]oxazole-2-aliphatic acid esters and hydroxylbenzo[d]oxazole-2- amino acid esters was successfully achieved in good yield by using Meerwein's reagent. Copyright Taylor & Francis G

Cobalt nanoclusters coated with N-doped carbon for chemoselective nitroarene hydrogenation and tandem reactions in water

Agostini, Giovanni,Calvino, Jose. J.,Corma, Avelino,Gutiérrez-Tarri?o, Silvia,Lopes, Christian W.,O?a-Burgos, Pascual,Rojas-Buzo, Sergio

supporting information, p. 4490 - 4501 (2021/06/28)

The development of active and selective non-noble metal-based catalysts for the chemoselective reduction of nitro compounds in aquo media under mild conditions is an attractive research area. Herein, the synthesis of subnanometric and stable cobalt nanoclusters, covered by N-doped carbon layers as core-shell (Co@NC-800), for the chemoselective reduction of nitroarenes is reported. TheCo@NC-800catalyst was prepared by the pyrolysis of the Co(tpy)2complex impregnated on Vulcan carbon. In fact, the use of a molecular complex based on six N-Co bonds drives the formation of a well-defined and distributed cobalt core-shell nanocluster covered by N-doped carbon layers. In order to elucidate its nature, it has been fully characterized by using several advanced techniques. In addition, this as-prepared catalyst showed high activity, chemoselectivity and stability toward the reduction of nitro compounds with H2and under mild reaction conditions; water was used as a green solvent, improving the previous results based on cobalt catalysts. Moreover, theCo@NC-800catalyst is also active and selective for the one-pot synthesis of secondary aryl amines and isoindolinones through the reductive amination of nitroarenes. Finally, based on diffraction and spectroscopic studies, metallic cobalt nanoclusters with surface CoNxpatches have been proposed as the active phase in theCo@NC-800material.

Ether compound and pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome

-

Paragraph 0250-0251; 0363-0365, (2021/07/24)

The invention relates to an ether compound and a pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome. Specifically, the invention provides a compound as shown in a formula (I), an isomer, a raceme, a prodrug, a solvate, a deuterated substance or a pharmaceutically acceptable salt thereof, and Ar1, Ar2, X, Y and R are defined in the specification.

ALPHA, BETA-UNSATURATED AMIDE COMPOUND

-

Paragraph 0934, (2020/12/10)

An object of the present invention is to provide an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like. The α,β-unsaturated amide compound represented by the following formula (I) or a pharmaceutically acceptable salt or the like thereof has anticancer activity and the like: [wherein, "A" represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents -O-, -S-, -SO2-, -NRX1- (wherein, RX1 represents hydrogen atom or lower alkyl), -CHRX2- (wherein, RX2 represents hydrogen atom or hydroxy), -CH=CH-, -CO- or -NH-CO-, and n1 and n2 are the same or different, and each represents 0 or 1].

PRMT5 INHIBITORS AND USES THEREOF

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Paragraph 0432-0433, (2019/04/05)

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.

Synthesis and biological evaluation of pyrimidine derivatives as novel human Pin1 inhibitors

Cui, Guonan,Jin, Jing,Chen, Hualong,Cao, Ran,Chen, Xiaoguang,Xu, Bailing

supporting information, p. 2186 - 2197 (2018/03/28)

Pin1 (Protein interacting with NIMA1) is a cis–trans isomerase and promotes the amide bond rotation of phosphoSer/Thr-Pro motifs in its substrates. Inhibition of Pin1 might be a novel strategy for developing anticancer agents. Herein, a series of pyrimidi

Expanding the Balz–Schiemann Reaction: Organotrifluoroborates Serve as Competent Sources of Fluoride Ion for Fluoro-Dediazoniation

Mohy El Dine, Tharwat,Sadek, Omar,Gras, Emmanuel,Perrin, David M.

supporting information, p. 14933 - 14937 (2018/09/25)

The Balz–Schiemann reaction endures as a method for the preparation of (hetero)aryl fluorides yet is eschewed due to the need for harsh conditions or high temperatures along with the need to isolate potentially explosive diazonium salts. In a departure from these conditions, we show that various organotrifluoroborates (RBF3?s) may serve as fluoride ion sources for solution-phase fluoro-dediazoniation in organic solvents under mild conditions. This methodology was successfully extended to a one-pot process obviating aryl diazonium salt isolation. Sterically hindered (hetero)anilines are fluorinated under unprecedentedly mild conditions in good-to-excellent yields. Taken together, this work expands the repertoire of RBF3?s to act as fluorine ion sources in an update to the classic Balz–Schiemann reaction.

a, ? UNSATURATED AMIDE COMPOUND

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Paragraph 0751, (2018/11/27)

The present invention provides an α,β-unsaturated amide compound or a pharmaceutically acceptable salt or the like thereof having anticancer activity and the like represented by the following formula (I): [wherein, "A" represents optionally substituted heterocyclic diyl, R1 represents hydrogen atom or optionally substituted lower alkyl, R2 represents optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted aliphatic heterocyclic group or optionally substituted aromatic heterocyclic group, X represents -O-, -S-, -SO2-, -NRX1- (wherein, RX1 represents hydrogen atom or lower alkyl), -CHRX2- (wherein, RX2 represents hydrogen atom or hydroxy), -CH=CH-, -CO- or -NH-CO-, and n1 and n2 are the same or different, and each represents 0 or 1].

HYDROXYL GROUP-CONTAINING MALEIMIDE COMPOUND

-

Paragraph 0071; 0072, (2018/07/28)

PROBLEM TO BE SOLVED: To provide a new hydroxyl group-containing maleimide compound excellent in a cure rate of an epoxy resin. SOLUTION: Provided are a maleimide compound having phenolic hydroxyl groups at 2-position and 6-position; a composition contain

Co-based heterogeneous catalysts from well-defined Α-diimine complexes: Discussing the role of nitrogen

Formenti, Dario,Ferretti, Francesco,Topf, Christoph,Surkus, Annette-Enrica,Pohl, Marga-Martina,Radnik, J?rg,Schneider, Matthias,Junge, Kathrin,Beller, Matthias,Ragaini, Fabio

, p. 79 - 89 (2017/05/10)

Ar-BIANs and related α-diimine Co complexes were wet impregnated onto Vulcan XC 72 R carbon black powder and used as precursors for the synthesis of heterogeneous supported nanoscale catalysts by pyrolysis under argon at 800?°C. The catalytic materials feature a core-shell structure composed of metallic Co and Co oxides decorated with nitrogen-doped graphitic layers (NGr). These catalysts display high activity in the liquid phase hydrogenation of aromatic nitro compounds (110?°C, 50 bar H2) to give chemoselectively substituted aryl amines. The catalytic activity is closely related to the amount and type of nitrogen atoms in the final catalytic material, which suggests a heterolytic activation of dihydrogen.

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