32137-19-2

Basic information

• Product Name: 3,4-Difluorobenzotrifluoride
• Synonyms: ALPHA,ALPHA,ALPHA,3,4-PENTAFLUOROTOLUENE;3,4-DIFLUOROBENZOTRIFLUORIDE;1,2-DIFLUORO-4-TRIFLUOROMETHYL-BENZENE;3,4-Difluorobenzotrifluoride, 97+%;à,à,à,3,4-pentafluorotoluene;3,4-Difluorobenzotrifluoride 98%;3,4-Difluorobenzotrifluoride98%;1,2-Difluoro-4-(trifluoromethyl)benzene, alpha,alpha,alpha,3,4-Pentafluorotoluene
• CAS NO: 32137-19-2
• Molecular Formula: C₇H₃F₅
• Molecular Weight: 182.09
• EINECS: -0
• Product Categories: Trifluoromethylbenzene serise;Benzotrifluoride Series
• Mol File: 32137-19-2.mol

Chemical Properties

• Melting Point: 95-98 °C
• Boiling Point: 103-104 °C
• Flash Point: 103-104°C
• Appearance: /
• Density: 1.41
• Vapor Pressure: 29.5mmHg at 25°C
• Refractive Index: 1.388-1.392
• Storage Temp.: Flammables area
• BRN: 1950149
• CAS DataBase Reference: 3,4-Difluorobenzotrifluoride(CAS DataBase Reference)
• NIST Chemistry Reference: 3,4-Difluorobenzotrifluoride(32137-19-2)
• EPA Substance Registry System: 3,4-Difluorobenzotrifluoride(32137-19-2)

Safety Data

• Hazard Codes: Xi-F,F,Xi
• Statements: 36/37/38-11
• Safety Statements: 37/39-26-16-36
• RIDADR: 1993
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 32137-19-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
3,4-Difluorobenzotrifluoride is used as a reactant in the preparation of arylacetonitriles, which are important intermediates in the synthesis of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its reactivity and stability make it a valuable component in the development of new compounds with specific applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3,4-Difluorobenzotrifluoride is utilized as a building block for the synthesis of novel drug candidates with potential therapeutic properties. Its unique structure allows for the creation of molecules with specific biological activities, targeting various diseases and conditions.
Used in Agrochemical Industry:
3,4-Difluorobenzotrifluoride is also employed in the agrochemical industry for the development of new pesticides and herbicides. Its incorporation into these compounds can enhance their effectiveness, selectivity, and environmental compatibility.
Used in Materials Science:
In the field of materials science, 3,4-Difluorobenzotrifluoride can be used as a component in the development of advanced materials with specific properties, such as high thermal stability, chemical resistance, or unique electronic characteristics. These materials can find applications in various industries, including electronics, aerospace, and automotive.

InChI:InChI=1/C7H3F5/c8-4-1-2-5(6(9)3-4)7(10,11)12/h1-3H

Upstream product

• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 
• 32137-18-1 1,2,7,7,8,8-Hexafluoro-5-trifluoromethyl-bicyclo[2.2.2]octa-2,5-diene 
• 77227-99-7 3,4-difluoro-5-chloro-α,α,α-trifluorotoluene 
• 112290-03-6 3,4-difluoro-6-chloro-trifluoromethylbenzene 

Downstream Products

• 455-86-7 3,4-Difluorobenzoic acid 
• 847547-01-7 4-(2-fluoro-4-trifluoromethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 328-84-7 1,2-dichloro-4-(trifluoromethyl)benzene 
• 32137-20-5 1-chloro-2-fluoro-4-(trifluoromethyl)benzene 
• 239087-11-7 [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile 
• 1257088-55-3 ethyl cyano[2-fluoro-4-(trifluoromethyl)phenyl]acetate 
• 1232367-10-0 2,3-difluoro-6-trifluoromethylphenyl lithium 
• 186517-43-1 2,3-difluoro-6-trifluoromethylbenzaldehyde 
• 186517-19-1 2,3-difluoro-6-trifluoromethylbenzaldoxime 
• 1232367-12-2 2-iodo-3,4-difluorobenzotrifluoride 
• 1314700-27-0 1-[2-fluoro-4-(trifluoromethyl)phenyl]cyclopropanecarbonitrile 
• 1620217-64-2 4-benzyl-1,2-difluorobenzene 
• 1416981-87-7 1,2-difluoro-4-(4-methylbenzyl)benzene 

Relevant articles and documents

AROMATIC FLUORINE CHEMISTRY. PART 1. 3,4-DIFLUOROBENZOIC ACID AND DERIVATIVES VIA 3,4-DIFLUOROBENZOTRIFLUORIDE

The preparation of 3,4-difluorobenzotrifluoride from 3,4-dichlorobenzotrifluoride by a KF exchange reaction is described.The conversion of 3,4-difluorobenzotrifluoride to 3,4-difluorobenzoic acid and derivatives is also reported.

A kind of boron-containing compounds and their use in catalytic fluorination reaction (by machine translation)

The invention relates to the field of fine chemical engineering, in particular to boron-containing compounds and application thereof in catalytic fluorination reaction. The boron-containing compoundsprovided by the invention are used as a catalyst and can be fluorinated by further mild reaction. Compared with the prior art, the boron-containing compounds have the advantages of mild conditions andhigh efficiency of the fluorination reaction, novel catalysis principle, simplicity and convenience in operation, less pollution, low solvent cost and suitability for industrial production.

Process for the dechlorination and/or debromination of fluorine-and chlorine- and/or bromine-containing aromatic compounds

Fluorine- and chlorine- and/or bromine-containing aromatic compounds are dechlorinated and/or debrominated with hydrogen in an industrially advantageous and selective manner, if the palladium catalyst is present in stationary phase and the aromatic compound in gas phase.

A General Procedure for the Fluorodenitration of Aromatic Substrates

The synthesis of several fluoroaromatic compounds by a new procedure of fluorodenitration of nitroarenes is reported.The methodology is based on the principle that the nitrite ion, generated during the fluorodenitration processes and responsible for most of the undesired side reactions, can be trapped with a suitable reagent, e.g., phthaloyl difluoride or tetrafluorophthaloyl difluoride.The yields of fluoro compounds thus obtained are good to excellent, and the procedure is of general application.

General and Highly Efficient Syntheses of m-Fluoro Arenes Using Potassium Fluoride-Exchange Method

Tetraphenylphosphonium bromide was found to be a suitable catalyst for the reaction of m-nitroaryl derivatives carrying cyano, nitro, chlorocarbonyl, trifluoromethyl, and chlorosulfonyl groups with potassium fluoride in the presence of a stoichiometric amount of phthaloyl dichloride, giving the corresponding m-fluoro aromatic derivatives in good yields.The catalyst was also found to be efficient for the fluorodesulfonylation of m-(fluorosulfonyl)aryl derivatives to afford m-fluoro arenes by the use of a reaction-distillation technique.

Fluorophenoxyphenoxypropionates and derivatives thereof

Novel fluorophenoxyphenoxypropionates and derivatives thereof possess herbicidal activity selectively in the presence of broadleaf crops. Preemergent and postemergent applications are contemplated.

Process for the preparation of benzotrifluorides which are substituted by fluorine and optionally in addition by chlorine

Benzotrifluorides substituted by fluorine and optionally in addition by chlorine, some of which are new, are prepared by hydrogenating benzotrifluorides which are substituted by fluorine and chlorine, in the presence of a catalyst and a hydrogen chloride acceptor.

Tetraphenylphosphonium Bromide Catalyzed Fluorodenitrations and Fluorodesulfonylations. Efficient Syntheses of m-Fluoroaromatic Compounds

Meta-fluoroaromatic compounds were effectively synthesized from m-nitroaromatic or m-fluorosulfonylaromatic compounds by replacement reaction with potassium fluoride in the presence of a catalytic amount of tetraphenylphosphonium bromide.

Fluorophenoxyphenoxypropionates and derivatives thereof

Novel intermediates useful in the preparation of fluorophenoxyphenoxypropionates and derivatives thereof which possess herbicidal activity selectively in the presence of broadleaf crops.

Fluorophenoxyphenoxypropionates and derivatives thereof

Novel intermediates useful in the preparation of fluorophenoxyphenoxypropionates and derivatives thereof which possess herbicidal activity selectively in the presence of broadleaf crops.