32580-41-9

Basic information

• Product Name: (2-Acetyl-4-nitrophenyl)amine
• Synonyms: (2-Acetyl-4-nitrophenyl)amine;2'-Amino-5'-nitroacetophenone;1-(2-amino-5-nitrophenyl)ethanone;1-(2-amino-5-nitrophenyl)ethan-1-one
• CAS NO: 32580-41-9
• Molecular Formula: C₈H₈N₂O₃
• Molecular Weight: 180.16
• Mol File: 32580-41-9.mol

Chemical Properties

• Melting Point: 151-152℃
• Boiling Point: 332.9 °C at 760 mmHg
• Flash Point: 155.1 °C
• Appearance: /
• Density: 1.333
• Vapor Pressure: 0.000141mmHg at 25°C
• Refractive Index: 1.613
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: (2-Acetyl-4-nitrophenyl)amine(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Acetyl-4-nitrophenyl)amine(32580-41-9)
• EPA Substance Registry System: (2-Acetyl-4-nitrophenyl)amine(32580-41-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 32580-41-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
(2-Acetyl-4-nitrophenyl)amine is used as an intermediate in the synthesis of various pharmaceutical products, contributing to the development of new medications.
Used in Cosmetic Formulation:
(2-Acetyl-4-nitrophenyl)amine is used as a key component in the formulation of cosmetic products, enhancing their effectiveness and performance.
Used in Agricultural Product Development:
(2-Acetyl-4-nitrophenyl)amine is used as a chemical intermediate in the development of agricultural products, potentially improving crop yields and protection.
Used in Biochemistry and Biotechnology Research:
(2-Acetyl-4-nitrophenyl)amine is used as a research compound in biochemistry and biotechnology, aiding in the investigation of various biological processes and the development of new techniques and applications.

InChI:InChI=1/C8H8N2O3/c1-5(11)7-4-6(10(12)13)2-3-8(7)9/h2-4H,9H2,1H3

Upstream product

• 41019-20-9 N-(2-acetyl-4-nitro-phenyl)-acetamide 
• 861611-98-5 1-(2-nitroamino-phenyl)-ethanone 
• 1678-04-2 benzoic acid-(2-acetyl-4-nitro-anilide) 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 1846-33-9 N-phenacylacetamide 

Downstream Products

• 65130-31-6 1-(2′-bromo-5′-nitrophenyl)ethan-1-one 
• 1678-04-2 benzoic acid-(2-acetyl-4-nitro-anilide) 
• 112290-88-7 2-cyano-5-nitroacetophenone 
• 1026916-62-0 N-(2-Acetyl-4-nitro-phenyl)-3-trifluoromethyl-benzamide 
• 1028305-45-4 N-(2-Acetyl-4-amino-phenyl)-3-chloro-benzamide 
• 1026981-84-9 N-(2-Acetyl-4-amino-phenyl)-3-methoxy-benzamide 
• 1027302-60-8 N-(2-Acetyl-4-amino-phenyl)-3-trifluoromethyl-benzamide 
• 112290-86-5 1,3-dioxolane-2-methyl-2-(2-cyano-5-aminophenyl) 
• 112290-84-3 1,3-dioxolane-2-methyl-2-<2-cyano-5-(N-methylamino)phenyl> 
• 112290-82-1 5-Amino-4-methylamino-2-(2-methyl-[1,3]dioxolan-2-yl)-benzonitrile 
• 112290-87-6 1,3-dioxolane-2-methyl-2(-2-cyano-5-nitrophenyl) 
• 112290-83-2 1,3-dioxolane-2-methyl-2-<2-cyano-4-nitro-5-(N-methylamino)phenyl> 
• 112290-85-4 1,3-dioxolane-2-methyl-2-<2-cyano-5-(N-trifluoroacetyl)phenyl> 

Relevant articles and documents

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Antitumor Agents. 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

A series of 3',6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI50/=-4.0; log drug molar concentration required to cause 50percent inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. The most potent compound (26) demonstrated strong cytotoxic effects with GI50 values in the nanomolar or subnanomolar range in almost all the tumor cell lines. Compound 26 was also a potent inhibitor of tubulin polymerization and radiolabeled colchicine binding to tubulin, with activity comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.

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