41019-20-9

Upstream product

• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 7664-93-9 sulfuric acid 
• 7697-37-2 nitric acid 

Downstream Products

• 32580-41-9 1-(2-amino-5-nitro-phenyl)ethanone 
• 141702-22-9 N-(2-acetyl-4-aminophenyl)acetamide 
• 1028305-45-4 N-(2-Acetyl-4-amino-phenyl)-3-chloro-benzamide 
• 1026981-84-9 N-(2-Acetyl-4-amino-phenyl)-3-methoxy-benzamide 
• 1027220-97-8 N-(2-Acetyl-4-nitro-phenyl)-3-chloro-benzamide 
• 1027302-60-8 N-(2-Acetyl-4-amino-phenyl)-3-trifluoromethyl-benzamide 
• 1026916-62-0 N-(2-Acetyl-4-nitro-phenyl)-3-trifluoromethyl-benzamide 
• 804561-28-2 acetic acid-(2-acetyl-4-nitroso-anilide) 
• 854897-28-2 6-amino-1H-cinnolin-4-one 
• 41019-23-2 benzoic acid-(2-acetyl-4-chloro-anilide) 
• 1678-04-2 benzoic acid-(2-acetyl-4-nitro-anilide) 
• 736145-10-1 benzoic acid-(2-acetyl-4-hydroxy-anilide) 
• 736145-09-8 benzoic acid-(2-acetyl-4-amino-anilide) 

Relevant academic research and scientific papers

Primary intermediate for use in oxidative hair dyeing

1-(2,5-Diaminophenyl)ethanol useful as a primary intermediate for the oxidative dyeing of hair.

Antitumor Agents. 155. Synthesis and Biological Evaluation of 3',6,7-Substituted 2-Phenyl-4-quinolones as Antimicrotubule Agents

A series of 3',6,7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI50/=-4.0; log drug molar concentration required to cause 50percent inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. The most potent compound (26) demonstrated strong cytotoxic effects with GI50 values in the nanomolar or subnanomolar range in almost all the tumor cell lines. Compound 26 was also a potent inhibitor of tubulin polymerization and radiolabeled colchicine binding to tubulin, with activity comparable to those of the potent antimitotic natural products colchicine, podophyllotoxin, and combretastatin A-4.