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327099-22-9

5-(3-fluorophenyl)-3-(4-chlorophenyl)-1',3',4,6-tetraoxohexahydrospiro(1H-furo[3,4-c]pyrrole-1,2'-indane) is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 327099-22-9 Structure

  • Basic information

    1. Product Name: 5-(3-fluorophenyl)-3-(4-chlorophenyl)-1',3',4,6-tetraoxohexahydrospiro(1H-furo[3,4-c]pyrrole-1,2'-indane)
    2. Synonyms: 5-(3-fluorophenyl)-3-(4-chlorophenyl)-1',3',4,6-tetraoxohexahydrospiro(1H-furo[3,4-c]pyrrole-1,2'-indane)
    3. CAS NO:327099-22-9
    4. Molecular Formula: C26H15ClFNO5
    5. Molecular Weight: 475.8524032
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 327099-22-9.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-(3-fluorophenyl)-3-(4-chlorophenyl)-1',3',4,6-tetraoxohexahydrospiro(1H-furo[3,4-c]pyrrole-1,2'-indane)(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-(3-fluorophenyl)-3-(4-chlorophenyl)-1',3',4,6-tetraoxohexahydrospiro(1H-furo[3,4-c]pyrrole-1,2'-indane)(327099-22-9)
    11. EPA Substance Registry System: 5-(3-fluorophenyl)-3-(4-chlorophenyl)-1',3',4,6-tetraoxohexahydrospiro(1H-furo[3,4-c]pyrrole-1,2'-indane)(327099-22-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 327099-22-9(Hazardous Substances Data)

327099-22-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 327099-22-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,7,0,9 and 9 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 327099-22:
(8*3)+(7*2)+(6*7)+(5*0)+(4*9)+(3*9)+(2*2)+(1*2)=149
149 % 10 = 9
So 327099-22-9 is a valid CAS Registry Number.

327099-22-9Downstream Products

327099-22-9Relevant articles and documents

The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation

Li, Shanshan,Song, Gao,Wang, Liang-Liang,Weng, Zhiying,Xu, Guowei,Yang, Weimin,Yang, Yanming,Yang, Yaqing,Zhang, Jiajun,Zuo, Zhili

, (2020/02/27)

Adenylate cyclases (ACs), play a critical role in the conversion of adenosine triphosphate (ATP) into the second messenger cyclic adenosine monophosphate (cAMP). Studies have indicated that adenylyl cyclase type 2 (AC2) is potential drug target for many diseases, however, up to now, there is no AC2-selective agonist reported. In this research, docking-based virtual screening with the combination of cell-based biological assays have been performed for discovering novel potent and selective AC2 agonists. Virtual screening disclosed a novel hit compound 8 as an AC2 agonist with EC50 value of 8.10 μM on recombinant human hAC2 + HEK293 cells. The SAR (structure activity relationship) based on the derivatives of compound 8 was further explored on recombinant AC2 cells and compound 73 was found to be the most active agonist with the EC50 of 90 nM, which is 160-fold more potent than the reported agonist Forskolin and could selectively activate AC2 to inhibit the expression of Interleukin-6. The discovery of a new class of AC2-selective agonists would provide a novel chemical probe to study the physiological function of AC2.

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