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327602-34-6

2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 327602-34-6 Structure

  • Basic information

    1. Product Name: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide
    2. Synonyms: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide;5,6-Dichloro-1,4-dihydro-2-quinazolinaMine HydrobroMide
    3. CAS NO:327602-34-6
    4. Molecular Formula: C8H8BrCl2N3
    5. Molecular Weight: 297
    6. EINECS: N/A
    7. Product Categories: Amines;Bases & Related Reagents;Impurities;Intermediates & Fine Chemicals;Isotope Labelled Compounds;Nucleotides;Pharmaceuticals;Amines, Impurities, Isotope Labelled Compounds, Nucleotides, Bases & Related Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
    8. Mol File: 327602-34-6.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
    8. Solubility: DMSO (Slightly), Methanol (Slightly)
    9. CAS DataBase Reference: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide(327602-34-6)
    11. EPA Substance Registry System: 2-AMino-5,6-dichloro-3,4-dihydroquinazoline HydrobroMide(327602-34-6)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 327602-34-6(Hazardous Substances Data)

327602-34-6 Usage

Uses

Anagrelide (A637300) metabolite, the major metabolite in hematopoietic cell cultures.

Check Digit Verification of cas no

The CAS Registry Mumber 327602-34-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,7,6,0 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 327602-34:
(8*3)+(7*2)+(6*7)+(5*6)+(4*0)+(3*2)+(2*3)+(1*4)=126
126 % 10 = 6
So 327602-34-6 is a valid CAS Registry Number.

327602-34-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide

1.2 Other means of identification

Product number -
Other names 5,6-dichloro-1,4-dihydroquinazolin-2-amine,hydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:327602-34-6 SDS

327602-34-6Downstream Products

327602-34-6Relevant articles and documents

Synthesis and stability of 3-hydroxyanagrelide, a biologically potent metabolite of anagrelide

Scott, Richard B.,Downey, Kristin M.,Healy, Keith P.,Henderson, Alistair P.,Robinson, Claire L.,Clegg, William,Harrington, Ross W.,Franklin, Richard,Golding, Bernard T.

, p. 1637 - 1646 (2013/08/23)

Metabolism of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]quinazolin- 2-one (anagrelide), a drug for treating essential thrombocythemia, gives 6,7-dichloro-3-hydroxy-1,5-dihydroimidazo[2,1-b]quinazolin-2-one (3-hydroxyanagrelide) and 2-amino-5,6-dichloro-3,4-dihydroquinazoline. To enable the properties of 3-hydroxyanagrelide to be fully evaluated, the racemic compound has been synthesized. In pH 7.4 aqueous buffer 3-hydroxyanagrelide readily equilibrates with an isomer, 6,7-dichloro-1-hydroxy-3,5- dihydroimidazo[1,2-a]- quinazolin-2-one, and is also hydrolyzed to 2-amino-5,6-dichloro-3,4-dihydroquinazoline. 3-Hydroxyanagrelide (half-life 40 hours) was the dominant species at equilibrium and it was concluded that the equilibration and decomposition are sufficiently slow that published assays of 3-hydroxyanagrelide are reliable.

2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof

-

, (2008/06/13)

The compound 2-amino-5,6-dichloro-3,4-dihydroquinazoline has been found to have enhanced platelet count reducing properties. Also provided are methods for synthetically making the compound and a method of reducing the platelet count in a patient by administering to the patient a platelet reducing effective amount of the compound preferably together with a pharmaceutically acceptable carrier. A pharmaceutical composition is also provided which contains the above compound as the active ingredient together with pharmaceutically acceptable excipients.

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