2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide

Base Information

• Chemical Name: 2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide
• CAS No.: 327602-34-6
• Molecular Formula: C8H8BrCl2N3
• Molecular Weight: 296.98
• DSSTox Substance ID: DTXSID20432647
• Mol file: 327602-34-6.mol

Synonyms:327602-34-6;2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide;5,6-Dichloro-3,4-dihydroquinazolin-2-amine hydrobromide;5,6-dichloro-1,4-dihydroquinazolin-2-amine;hydrobromide;SCHEMBL7073905;5,6-Dichloro-1,4-dihydro-2-quinazolinamine Hydrobromide;DTXSID20432647;SZFQKLLDGWIZJF-UHFFFAOYSA-N;FT-0661723;J-018869

Chemical Property of 2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide

Chemical Property:

• PSA: 47.91000
• LogP: 3.96790
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 294.92787
• Heavy Atom Count: 14
• Complexity: 231

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C2=C(C=CC(=C2Cl)Cl)NC(=N1)N.Br
• Uses: Anagrelide (A637300) metabolite, the major metabolite in hematopoietic cell cultures.

Technology Process of 2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide

There total 3 articles about 2-Amino-5,6-dichloro-3,4-dihydroquinazoline Hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

bromocyane (506-68-3) + 6-amino-2,3-dichlorobenzylamine (147249-42-1) → 2-amino-5,6-dichloro-3,4-dihydroquinazoline hydrogen bromide (327602-34-6)

Guidance literature:

In hexane; toluene;

Reference yield: 50.0%

2,3-dichlorobenzylaldehyde (6334-18-5) → 2-amino-5,6-dichloro-3,4-dihydroquinazoline hydrogen bromide (327602-34-6)

Guidance literature:

With nitric acid; In sulfuric acid; water;

Reference yield: 47.0%

cyanogen bromide + 6-amino-2,3-dichlorobenzylamine (147249-42-1) → 2-amino-5,6-dichloro-3,4-dihydroquinazoline hydrogen bromide (327602-34-6)

Guidance literature:

In toluene; at 20 - 75 ℃; for 2.5h; Reflux;

DOI:10.3987/COM-12-S(N)115

upstream raw materials:

2,3-dichlorobenzylaldehyde

bromocyane

6-amino-2,3-dichlorobenzylamine

Downstream raw materials:

C₁₄H₁₅Cl₂N₃O₃

Refernces

• 1、 -. "2-amino-5,6-dichloro-3,4-dihydroquinazoline, its method of making and using and pharmaceutical compositions thereof". . . Retrieved 2008/06/13.