33007-99-7

Basic information

• Product Name: 6-BROMO-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID
• Synonyms: AKOS AUF0611;6-BROMO-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID;4-Quinolinecarboxylic acid, 6-bromo-2-phenyl-;6-Bromo-2-phenylcinchoninic acid;6-bromo-2-phenyl-cinchoninic acid;Cinchoninic acid, 6-bromo-2-phenyl-
• CAS NO: 33007-99-7
• Molecular Formula: C₁₆H₁₀BrNO₂
• Molecular Weight: 328.16
• Mol File: 33007-99-7.mol

Chemical Properties

• Boiling Point: 502.3 °C at 760 mmHg
• Flash Point: 257.6 °C
• Appearance: /
• Density: 1.556 g/cm³
• Vapor Pressure: 6.56E-11mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: 6-BROMO-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID(33007-99-7)
• EPA Substance Registry System: 6-BROMO-2-PHENYL-QUINOLINE-4-CARBOXYLIC ACID(33007-99-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 33007-99-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
6-Bromo-2-phenylquinoline-4-carboxylic acid is used as a reactant for the preparation of (triazolothiadiazolyl)quinolines. These compounds are of interest in the pharmaceutical industry due to their potential therapeutic properties. The condensation of aminotriazolethiols with quinolinecarboxylates, such as 6-bromo-2-phenylquinoline-4-carboxylic acid, leads to the formation of these bioactive molecules, which can be further explored for their pharmacological applications.
Additionally, due to the structural diversity and functional group versatility of 6-bromo-2-phenylquinoline-4-carboxylic acid, it can be potentially used in the synthesis of other complex organic molecules, which may find applications in various industries such as agrochemicals, dyes, and materials science. However, further research and development are required to fully explore and establish the utility of this compound in these areas.

InChI:InChI=1/C16H10BrNO2/c17-11-6-7-14-12(8-11)13(16(19)20)9-15(18-14)10-4-2-1-3-5-10/h1-9H,(H,19,20)

Upstream product

• 87-48-9 5-Bromo-1H-indole-2,3-dione 
• 98-86-2 acetophenone 

Downstream Products

• 148887-74-5 [(6-Bromo-2-phenyl-quinoline-4-carbonyl)-methyl-amino]-acetic acid ethyl ester 
• 313241-21-3 ethyl 6-bromo-2-phenylquinoline-4-carboxylate 
• 415716-05-1 (6-bromo-2-phenyl-[4]quinolyl)-carbamic acid ethyl ester 
• 859938-24-2 6-bromo-2-phenyl-quinoline-4-carbonyl azide 
• 304664-08-2 6-bromo-2-phenyl-quinoline-4-carboxylic acid hydrazide 
• 856046-33-8 6-bromo-2-phenyl-[4]quinolylamine 
• 148887-87-0 [(6-Bromo-2-phenyl-quinoline-4-carbothioyl)-methyl-amino]-acetic acid ethyl ester 

Relevant articles and documents

Synthesis and aldose reductase inhibitory activity of N-(quinolinyl thiocarbonyl) glycine derivatives

The onset of diabetic complications may be prevented by the inhibition of aldose reductase.Derivatives of N-(quinolinyl thiocarbonyl) glycine were prepared and their in vitro and ex vivo aldose reductase inhibitory activities were tested on rat lens.The cincophen derivatives were the most potent in vitro with an enzyme inhibition value of 29percent at 10-8 M and 91percent at 10-7 for the N--N-methylglycine compound 10a.This activity was shown to be dependent on the nature of the substituents and seems to be optimal for the acids; esterswerefound to be inactive.No compound have shown ex vivo inhibitory activity.It is concluded that the lack of ex vivo activity is likely due to a poor bioavailability or a bad penetration of the compounds in target tissue (lens). aldose reductase inhibitors / diabetic complications / N-(quinolinyl thiocarbonyl) glycine