33097-39-1

Basic information

• Product Name: 3,6-difluoropyridazine
• Synonyms: 3,6-difluoropyridazine;3,6-Difluoro-1,2-diazine;3,6-Difluoropyridazine 95+%
• CAS NO: 33097-39-1
• Molecular Formula: C₄H₂F₂N₂
• Molecular Weight: 116.07
• Mol File: 33097-39-1.mol

Chemical Properties

• Boiling Point: 204.3 °C at 760 mmHg
• Flash Point: 77.4 °C
• Appearance: /
• Density: 1.376 g/cm³
• Vapor Pressure: 0.378mmHg at 25°C
• Refractive Index: 1.444
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: -0.86±0.10(Predicted)
• CAS DataBase Reference: 3,6-difluoropyridazine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-difluoropyridazine(33097-39-1)
• EPA Substance Registry System: 3,6-difluoropyridazine(33097-39-1)

Safety Data

• Hazardous Substances Data: 33097-39-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
3,6-difluoropyridazine is used as a key building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure and reactivity allow for the development of new and effective compounds with potential therapeutic and pesticidal properties.
Used in Dye and Pigment Industries:
3,6-difluoropyridazine serves as a precursor in the manufacture of dyes and pigments, contributing to the creation of a wide range of colorants for various applications, including textiles, plastics, and printing inks.
Used in Organic Chemistry Research:
Due to its high reactivity, 3,6-difluoropyridazine is commonly used as a versatile intermediate in organic chemistry for the preparation of diverse chemical products. It enables the synthesis of complex molecules and the exploration of novel chemical reactions.
Safety Precautions:
While 3,6-difluoropyridazine offers numerous applications, it is essential to handle it with care. Being flammable and potentially hazardous to health, proper safety measures should be taken during its use and storage to minimize risks.

InChI:InChI=1/C4H2F2N2/c5-3-1-2-4(6)8-7-3/h1-2H

Upstream product

• 141-30-0 3,6-dichlorpyridazine 

Downstream Products

• 108784-42-5 6-fluoro-pyridazin-3-yl amine 
• 100240-46-8 3-fluoro-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyridazine 

Relevant articles and documents

Synthesis and herbicidal evaluation of 3-N-substituted amino-6-benzyloxypyridazine derivatives

A variety of 3-N-substituted amino-6-benzyloxypyridazine derivatives were designed and synthesized in satisfactory yields. Their structures were confirmed by IR, 1H-NMR, and elemental analysis; compound 5j was further determined by X-ray diffraction crystallography. Their herbicidal activities were evaluated through barnyard grass and rape cup tests in laboratory bioassays. Most of the title compounds 5 displayed moderate herbicidal activities against the dicotyledonous plant Brassica campestris L. The most active compounds in the laboratory were also evaluated in the greenhouse.

Room-temperature nucleophilic aromatic fluorination: Experimental and theoretical studies

(Chemical Equation Presented) Taming the reagent: The use of anhydrous tetrabutylammonium fluoride (TBAFanh) in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes (see scheme), was investigated. It was shown that TBAFanh permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media.

Selective fluorination by halogen exchange of chlorodiazines and chloropyridines promoted by the 'proton sponge' - Triethylamine tris(hydrogen fluoride) system

The 'proton sponge' - triethylamine tris(hydrogen fluoride) mixtures provide a mild and efficient fluorinating reagent to introduce selectively fluorine atoms by halogen exchange into chlorodiazines and chloronitropyridine series.

The proton sponge-triethylamine tris(hydrogen fluoride) system as a selective nucleophilic fluorinating reagent for chlorodiazines

The proton sponge-triethylamine tris(hydrogen fluoride) mixture provides a mild and efficient fluorinating - reagent for the selective introduction of a fluorine atom, by halogen exchange, into dichlorodiazines. (C) 2000 Elsevier Science Ltd.

Halogen-Exchange Fluorination of Aromatic Halides with HF or HF-Base

Heteroatomic halides such as 2-chloropyrimidines and 2-chloropyridines, and 2,4-dinitrochlorobenzene underwent halogen-exchange fluorination with the treatment of HF or HF-base solutions to afford the corresponding fluorides in good yields.