3,6-difluoropyridazine

Base Information

• Chemical Name: 3,6-difluoropyridazine
• CAS No.: 33097-39-1
• Molecular Formula: C4H2F2N2
• Molecular Weight: 116.07
• Hs Code.: 2933990090
• Mol file: 33097-39-1.mol

Synonyms:3,6-Difluoropyridazine;

Chemical Property of 3,6-difluoropyridazine

Chemical Property:

• Vapor Pressure: 0.378mmHg at 25°C
• Refractive Index: 1.444
• Boiling Point: 204.3 °C at 760 mmHg
• PKA: -0.86±0.10(Predicted)
• Flash Point: 77.4 °C
• PSA: 25.78000
• Density: 1.376 g/cm³
• LogP: 0.75480
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

3,6-Difluoropyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,6-difluoropyridazine

There total 3 articles about 3,6-difluoropyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.6%

3,6-dichlorpyridazine (141-30-0) → 3,6-difluoropyridazine (33097-39-1)

Guidance literature:

With potassium fluoride; In sulfolane; at 150 - 180 ℃; for 13h;

DOI:10.1002/jhet.1831

Reference yield: 53.0%

3,6-dichlorpyridazine (141-30-0) → 6-chloro-3-fluoropyridazine (33097-38-0) + 3,6-difluoropyridazine (33097-39-1)

Guidance literature:

With triethylamine; 1,8-bis(dimethylamino)naphthalene tris(hydrogen fluoride); at 80 ℃; for 96h;

DOI:10.1016/S0040-4039(00)01054-6

Reference yield:

→ 3,6-difluoropyridazine (33097-39-1)

Guidance literature:

Pyridazin 8, H2/Pd-C;

DOI:10.1021/ja00728a063

upstream raw materials:

3,6-dichlorpyridazine

Downstream raw materials:

6-fluoro-pyridazin-3-yl amine

3-fluoro-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyridazine

Refernces

• 1、 Zhang, Min,Hu, Fang-Zhong,Zhao, Ting,Yang, Liu-Qing,Yang, Hua-Zheng. "Synthesis and herbicidal evaluation of 3-N-substituted amino-6-benzyloxypyridazine derivatives". . p. 1404 - 1409. Retrieved 2015/04/27.
• 2、 Darabantu, Mircea,Lequeux, Thierry,Pommelet, Jean-Claude,Plé, Nelly,Turck, Alain. "Selective fluorination by halogen exchange of chlorodiazines and chloropyridines promoted by the 'proton sponge' - Triethylamine tris(hydrogen fluoride) system". . p. 739 - 750. Retrieved 2007/10/03.