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5-(4-CHLOROPHENYL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBALDEHYDE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 5-(4-chlorophenyl)-3-phenyl-4,5-dihydro-1H-pyrazole-1-carbaldehyde

    Cas No: 336168-27-5

  • USD $ 1.9-2.9 / Gram

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  • 336168-27-5 Structure
  • Basic information

    1. Product Name: 5-(4-CHLOROPHENYL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBALDEHYDE
    2. Synonyms: 5-(4-CHLOROPHENYL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBALDEHYDE
    3. CAS NO:336168-27-5
    4. Molecular Formula: C16H13ClN2O
    5. Molecular Weight: 284.74
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 336168-27-5.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 5-(4-CHLOROPHENYL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBALDEHYDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 5-(4-CHLOROPHENYL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBALDEHYDE(336168-27-5)
    11. EPA Substance Registry System: 5-(4-CHLOROPHENYL)-3-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBALDEHYDE(336168-27-5)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 336168-27-5(Hazardous Substances Data)

336168-27-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 336168-27-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,6,1,6 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 336168-27:
(8*3)+(7*3)+(6*6)+(5*1)+(4*6)+(3*8)+(2*2)+(1*7)=145
145 % 10 = 5
So 336168-27-5 is a valid CAS Registry Number.

336168-27-5Relevant articles and documents

N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H

Raghav,Garg

, p. 43 - 50 (2014/11/27)

Cathepsins, intracellular proteases, are known to be involved in a number of physiological processes ranging from degradation of extracellular proteins, prohormone processing, progressions of atherosclerosis, etc. High levels of cathepsins have been indicated in various pathological conditions like arthritis, cancer and other tissue degenerative disorders. One of the reasons attributed to these high levels is decrease in inhibitor concentration. Therefore, the work on the identification of small molecular weight compounds as inhibitors of cysteine proteases is of great therapeutic significance. Exploring this work in the same direction, we here present the synthesis of substituted N-formylpyrazolines and N-benzoylpyrazolines and study these as inhibitors to cysteine proteases. After a preliminary screening of the compounds as inhibitors to cysteine proteases in general, studies were carried out to study their inhibitory effects on cathepsin B and cathepsin H. SAR studies show that N-formylpyrazolines were better inhibitors than N-benzoylpyrazolines. The most potent inhibitors among the two series were nitro substituted compounds 1i and 2i with Ki values of ~1.1 × 10-9 M and 19.5 × 10-8 M for cathepsin B and Ki values of ~5.19 × 10-8 M and 9.8 × 10-7 M for cathepsin H, respectively. Docking experiments showing interaction between N-formylpyrazolines and N-benzoylpyrazolines with enzyme active sites structures also provided useful insights.

N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H

Raghav,Garg

supporting information, p. 43 - 50 (2014/12/11)

Cathepsins, intracellular proteases, are known to be involved in a number of physiological processes ranging from degradation of extracellular proteins, prohormone processing, progressions of atherosclerosis, etc. High levels of cathepsins have been indicated in various pathological conditions like arthritis, cancer and other tissue degenerative disorders. One of the reasons attributed to these high levels is decrease in inhibitor concentration. Therefore, the work on the identification of small molecular weight compounds as inhibitors of cysteine proteases is of great therapeutic significance. Exploring this work in the same direction, we here present the synthesis of substituted N-formylpyrazolines and N-benzoylpyrazolines and study these as inhibitors to cysteine proteases. After a preliminary screening of the compounds as inhibitors to cysteine proteases in general, studies were carried out to study their inhibitory effects on cathepsin B and cathepsin H. SAR studies show that N-formylpyrazolines were better inhibitors than N-benzoylpyrazolines. The most potent inhibitors among the two series were nitro substituted compounds 1i and 2i with Kivalues of ~1.1 × 10-9M and 19.5 × 10-8M for cathepsin B and Kivalues of ~5.19 × 10-8M and 9.8 × 10-7M for cathepsin H, respectively. Docking experiments showing interaction between N-formylpyrazolines and N-benzoylpyrazolines with enzyme active sites structures also provided useful insights.

Alternate synthesis route of 2-(substituted phenyl)-3,3a-dihydro-8H- pyrazolo[5,1-a[isoindol-8-ones via chalcone-based n-formyl-pyrazolines

Ahmed, Naseem,Dev, Dharm

, p. 689 - 704 (2013/01/15)

An alternate approach to 2-(substituted phenyl)-3,3a-dihydro-8H-pyrazolo[5, l-a] isoindol-8-ones via chalcone-based N-formyl-pyrazolines is described. N-Formyl-pyrazolines were prepared in excellent yield (81-96%) by the reaction of chalcones with hydrazine hydrate in the presence of formic acid, which undergoes intramolecular Friedel-Crafts acylation in the presence of trifluoroacetic acid (TFA) as a catalyst to afford functionalized 2-(substituted phenyl)-3,3a-dihydro-8H-pyrazolo[5,1-a]isoindol-8-ones in good to excellent yield (74-94%) at reflux in acetonitrile. Our synthetic route avoids expensive reagents and significantly improves yields.

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