Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives
Cancer treatment is one of the major public health issues in the world. Tetrandrine (Tet) and fangchinoline (d-Tet) are two bis-benzyl isoquinoline alkaloids extracted from Stephania tetrandra S. Moore, and their antitumor activities have been confirmed.
Bioactive bisbenzylisoquinoline alkaloids from the roots of Stephania tetrandra
Ten new bisbenzylisoquinoline alkaloids (1–10) and eight known analogues (11–18) were obtained from the roots of Stephania tetrandra. The structures of these compounds were determined by spectroscopic methods, single-crystal X-ray diffraction, electronic
Li, Jiayuan,Li, Li,Li, Xuyu,Liu, Yanfei,Shi, Guoru,Wang, Renzhong,Yu, Dequan,Yuan, Jiqiao,Zhou, Jie
(2020/03/17)
REGIOSELECTIVE O-DEMETHYLATION OF BISBENZYLISOQUINOLINE ALKALOIDS
The cleavage of methyl ethers of several bisbenzylisoquinoline alkaloids was studied and regioselective O-demethylation was observed.