- Full-synthetic method of racemic tetrandrine
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The invention discloses a full-synthetic method of racemic tetrandrine, and belongs to the technical field of drug synthesis. The full-synthetic method of the racemic tetrandrine comprises the steps that a synthetic route adopts a convergence synthesis method, a 5-bromovanillin, namely a compound 1 and 3-hydroxy-4-methoxyphenylacetic acid, namely a compound 5 are taken as starting materials to obtain a compound 4 and a compound 6 respectively, then the compound 4 and the compound 6 are taken as raw materials to synthesize a compound 11, a compound 19 is synthesized from the compound 11, and finally, the compound 11 reacts with the compound 19. The full-synthetic method of the racemic tetrandrine has the advantages that the synthetic efficiency is higher, the yield is higher, and the cost is lower; the reaction conditions are milder, the operation is simple and convenient, the industrial value is higher, and a reference is provided for the full-synthetic method of optical voidness tetrandrine.
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- ALKALOIDS OF DEHAASIA TRIANDRA
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Separation of the basic fraction from Dehaasia triandra afforded two new bisbenzylisoquinoline alkaloids, dehatridine and dehatrine, along with six known alkaloids, isocorydine, corytuberine, atheroline, nantenine, obaberine and a quaternary aporphine alkaloid, xanthoplanine (5). - Keywords: Dehaasia triandra; Lauraceae; Iau-Guoo-Nan; bisbenzylisoquinoline alkaloids; dehatridine; dehatrine.
- Lu, Sheng-Teh,Tsai, Ian-Lih,Leou, Shiow-Piaw
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p. 615 - 620
(2007/10/02)
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- Alcaloides bisbenzylisoquinoleiques de Albertisia cf. A. papuana
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Four new bisbenzylisoquinoline alkaloids were obtained from Albertisia cf.A. papuana Becc. (Menispermaceae).These are (-)-2,2'-bisnorphaeanthine (5), (+)-pangkoramine (7), (+)-pangkorimine (9), and (+)-2'-norcocsuline (14).They are accompanied by the known (+)-daphnoline (2), which is the main alkaloid, and by seven known dimers with one, two, or three ether bridges
- Lavault, Marie,Bruneton, Jean,Cave, Adrien,Chan, Kai Cheong,Deverre, Jean Robert,et al.
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p. 343 - 347
(2007/10/02)
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