339016-67-0

Basic information

• Product Name: 4-METHOXY-2-PHENOXYNICOTINONITRILE
• Synonyms: 4-METHOXY-2-PHENOXYNICOTINONITRILE;4-methoxy-2-phenoxypyridine-3-carbonitrile
• CAS NO: 339016-67-0
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 226.23
• Mol File: 339016-67-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-METHOXY-2-PHENOXYNICOTINONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2-PHENOXYNICOTINONITRILE(339016-67-0)
• EPA Substance Registry System: 4-METHOXY-2-PHENOXYNICOTINONITRILE(339016-67-0)

Safety Data

• Hazardous Substances Data: 339016-67-0(Hazardous Substances Data)

Upstream product

• 21642-98-8 4-methoxy-2-oxo-1,2-dihydropyridine-3-carbonitrile 
• 98645-43-3 2-chloro-3-cyano-4-methoxypyridine 
• 108-95-2 phenol 

Downstream Products

• 816454-34-9 N-(4-{[(4-phenoxy-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]methyl}phenyl)acetamide 
• 816454-22-5 4-phenoxy-1H-pyrazolo[4,3-c]pyridin-3-amine 

Relevant articles and documents

Substituent Effects of 2-Pyridones on Selective O-Arylation with Diaryliodonium Salts: Synthesis of 2-Aryloxypyridines under Transition-Metal-Free Conditions

An efficient transition-metal-free strategy to synthesize 2-aryloxypyridine derivatives has been developed by a selective O-arylation of 2-pyridones with diaryliodonium salts. The reaction was compatible with a series of functional groups for 2-pyridones and diaryliodonium salts such as halides, nitro, cyano, and ester groups. The substituents at the C6-position of 2-pyridones favored O-arylation products because of steric hindrance. The reaction was easily performed on a gram-scale and 6-chloro-2-pyridone was a good precursor to access various unsubstituted 2-aryloxypyridines by dehalogenation. A P2Y 1 lead compound analogue could be prepared in good yield over two steps.

Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity

The design and synthesis of a new series of c-Jun N-terminal kinase inhibitors are reported. The novel series of substituted amino indazoles were designed based on a combination of hits from high-throughput screening and X-ray crystal structure informatio

INDAZOLE/PYRZOLO[4,3-c]PYRIDIN DERIVATIVES AS JNK INHIBITORS, COMPOSITIONS AND METHODS RELATED THERETO AS WELL AS INTERMEDIATE THEREOF

The present invention relates to new compounds of formula (I) in which:X is CR4 or N; R1 is -OR5, -NHCOR6 or -NR6R7; R2 is hydrogen, Oar1 or -NHAr1 wherein Ar1 is aryl optionally substituted with one or more of R8, -OR8, -NR8R9, -CONR8R9, -COOR8, -NR8COR9, -SR8, -SO2NR8R9, -NR8SO2 R9, halogen, cyano, or nitro; R3 is hydrogen or -NHAr2 wherein Ar2 is benzene optionally substituted with one or more of R8, -OR8, -NR8R9, halogen or nitro, wherein R2 and R3 is not simultaneously hydrogen; a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.