339315-18-3

Basic information

• Product Name: Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-
• Synonyms: Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-
• CAS NO: 339315-18-3
• Molecular Formula: C₉H₁₇NO₄
• Molecular Weight: 0
• Mol File: 339315-18-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-(339315-18-3)
• EPA Substance Registry System: Alanine, N-(3-hydroxy-2,2-dimethyl-1-oxopropyl)-2-methyl-(339315-18-3)

Safety Data

• Hazardous Substances Data: 339315-18-3(Hazardous Substances Data)

Upstream product

• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 339315-16-1 3-hydroxy-2,2-dimethyl-N-[1-methyl-1-(N-methyl-N-phenylcarbamoyl)ethyl]propanamide 

Downstream Products

• 339315-35-4 2-[(2-benzyl-2-({2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl}amino)-1-oxopropyl)amino]-2,N,N-trimethylpropanamide 
• 339315-36-5 2-benzyl-2-[(2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-2-methyl-1-oxopropyl]amino}-2-methyl-1-oxopropyl)amino]-N,N-dimethylpropanamide 
• 339315-26-3 2-benzyl-2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}-N,N-dimethylpropanamide 
• 339315-27-4 2-{[2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-2-methyl-1-oxopropyl]amino}-N,2-dimethyl-N-phenylpropanamide 
• 339315-30-9 2-benzyl-2-{[-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxopropyl}amino)-2-methyl-1-oxopropyl]amino}propanoic acid 
• 339315-20-7 2-({2-[(3-hydroxy-2,2-dimethyl-1-oxopropyl)amino]-2-methyl-1-oxo-propyl}amino)-N,2-dimethyl-N-phenylpropanamide 

Relevant articles and documents

An unexpected formation of a 14-membered cyclodepsipeptide

The treatment of diluted solutions of the hydroxy diamides 6a and 6b in toluene with HCl gas at 100° gave the dimeric, 14-membered cyclodepsipeptide 10 in up to 72% yield (Scheme 3). The same product was formed from the linear dimer of 6b, the depsipeptid

Synthesis of conformationally restricted cyclic pentadepsipeptides via direct amide cyclization

The 2,2-disubstituted 2H-azirin-3-amines 6 (3-amino-2H-azirines) were used as building blocks for α,α-disubstituted α-amino acids in the preparation of 16-membered cyclic depsipeptides 14. The linear precursors containing four α,α-disubstituted α-amino acids, the pentapeptides 13, were synthesized starting with β-hydroxy acids 5 via the 'azirine/oxazolone method'. The cyclic depsipeptides 14 were formed via 'direct amide cyclization' and the influence of several factors on this cyclization was investigated in the following way: (a) using the same composition of α,α-disubstituted α-amino acids, but changing their respective positions in the peptide chain; (b) using different C-terminal α,α-disubstituted α-amino acids in the peptide chain; (c) using different β-hydroxy acids; and (d) using different diastereoisomers of the peptides.