34081-17-9Relevant articles and documents
SYNTHESIS OF TYROSINE DERIVED DIPHENOL MONOMERS
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Paragraph 0054; 0055; 0056, (2019/01/06)
A method for preparing diphenol compounds includes adding a hydroxyphenyl carboxylic acid, a tyrosine ethyl ester, hydroxybenzotriazole hydrate and a solvent and stirring to produce a first solution, EDCI HCI is added to the first solution to produce a fi
Resolution of N-protected amino acid esters using whole cells of Candida parapsilosis ATCC 7330
Stella, Selvaraj,Chadha, Anju
experimental part, p. 457 - 460 (2010/06/21)
Whole cells of Candida parapsilosis ATCC 7330 were used for the resolution of N-acetyl amino acid esters. Excellent enantioselectivities (E = 40 to >500) were achieved for the resolution of N-protected protein and non-protein amino acid esters giving good yields (28-50%) and high enantiomeric excesses (up to >99%) for both enantiomers.
4,4-Dimethyl-1,2,3,4-tetrahydroquinoline-based PPARα/γ agonists. Part. II: Synthesis and pharmacological evaluation of oxime and acidic head group structural variations
Parmenon, Cecile,Guillard, Jerome,Caignard, Daniel-Henri,Hennuyer, Nathalie,Staels, Bart,Audinot-Bouchez, Valerie,Boutin, Jean-Albert,Dacquet, Catherine,Ktorza, Alain,Viaud-Massuard, Marie-Claude
scheme or table, p. 2683 - 2687 (2010/03/24)
Type-2 diabetes (T2D) is a complex metabolic disease characterized by insulin resistance in the liver and peripheral tissues accompanied by a deficiency in pancreatic β-cells. Since their discovery, three subtypes of peroxisome proliferator activated receptors have been identified, namely PPARα, PPARγ and PPARβ/(δ). In this study, we were interested in designing novel PPARγ selective agonists and/or dual PPARα/γ agonists. Based on the typical topology of synthetic PPAR agonists, we focused our design approach on using 4,4-dimethyl-1,2,3,4-tetrahydroquinoline as a novel cyclic scaffold with oxime and acidic head group structural variations.
New Type of Aldol Condensations Catalyzed by Metal(II) Complexes of α-Amino Acid Esters and that with Cyclodextrin System
Watanabe, Ken-ichi,Yamada, Yoichi,Goto, Katsuhisa
, p. 1401 - 1406 (2007/10/02)
The aldol condensation of p-nitrobenzaldehyde with acetone catalyzed by metal ccomplexes of α-amino acid esters proceeded under mild and neutral conditions to afford an enantiomeric excess aldol-type products, 4-hydroxy-4-(4-nitrophenyl)-2-butanone, along with same dehydrated products without any by-product.The most effective catalyst system was a zinc(II) complex of the tyrosine ethyl ester, Zn(II)-(TyrOEt)2 in MeOH.Complexes of the second-row transition metals were inadeguate for the reactions.Reactions at 30-40 deg C for 24 h were fovorable regarding the asymmetric induction.An H2O solvent was the best for aldol-type product formation without asymmetric induction.An assistand effect of cyclodextrins(especially, β-CD) on the catalysis of the Zn(II)-TyrOEt complex were thought to be observed.