342017-94-1

Basic information

• Product Name: 2-(4-BROMOPHENYL)-6-CHLOROQUINOLINE-4-CARBOXYLICACID
• Synonyms: 2-(4-BROMOPHENYL)-6-CHLOROQUINOLINE-4-CARBOXYLICACID;2-(4-bromophenyl)-6-chloro-4-quinolinecarboxylic acid;2-(4-bromophenyl)-6-chloro-cinchoninic acid;4-Quinolinecarboxylic acid, 2-(4-bromophenyl)-6-chloro-;A2497/0106210;AIDS228061;AIDS-228061;EU-0042456
• CAS NO: 342017-94-1
• Molecular Formula: C₁₆H₉BrClNO₂
• Molecular Weight: 362.60516
• Mol File: 342017-94-1.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-BROMOPHENYL)-6-CHLOROQUINOLINE-4-CARBOXYLICACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOPHENYL)-6-CHLOROQUINOLINE-4-CARBOXYLICACID(342017-94-1)
• EPA Substance Registry System: 2-(4-BROMOPHENYL)-6-CHLOROQUINOLINE-4-CARBOXYLICACID(342017-94-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 342017-94-1(Hazardous Substances Data)

Usage

Molecular structure

2-(4-Bromophenyl)-6-chloroquinoline-4-carboxylic acid contains a complex structure with a bromophenyl group, a chloroquinoline group, and a carboxylic acid group.

Usage in pharmaceutical research

This chemical compound is commonly used in pharmaceutical research, particularly in the development of new drugs for various medical conditions.

Reactivity and interaction

The presence of both the bromine and chlorine atoms in the structure indicates potential for reactivity and interaction with other molecules, making it a valuable component in drug design and synthesis.

Upstream product

• 17630-76-1 5-chloroindole 2,3-dione 
• 99-90-1 para-bromoacetophenone 
• 98-86-2 acetophenone 
• 65798-06-3 N-(4-chlorophenyl)-2-(hydroxyimino)ethanamide 
• 106-47-8 4-chloro-aniline 

Downstream Products

• 918296-19-2 6-chloro-2-(4-bromophenyl)quinoline-4-carboxylic acid hydrazide 
• 1373425-26-3 C₂₂H₁₃BrCl₂N₂O 

Relevant articles and documents

Design, synthesis and evaluation of quinoline-based small molecule inhibitor of stat3

As STAT3 has been validated as an anticancer target, its inhibitors have been shown to possess therapeutic promise for the treatment of human cancers. To identify novel and selective STAT3 inhibitors, a virtual screening based on the STAT3 SH2 domain was performed and a small molecule, 2-phenylquinoline-4- carboxylic acid (5a), with an inhibition constant Ki value of 17.53 iM to STAT3 was discovered. On this basis, the derivatives of 5a including esters, amides and dimers were synthesized. The bioactivity and inhibitory selectivity of the derivatives were assayed using human breast cancer cell lines, MDA-MB-468 and MCF-7. Among the derivatives, 5c and 9b showed the most potent inhibitory activity with a good selectivity, and also inhibited STAT3 protein level of MDA-MB-468 cells. The results demonstrated a successful application of virtual screening for lead discovery. Compound 9b might be an effective STAT3 inhibitor lead for the further development of antitumor agents.

SAR-based optimization of a 4-quinoline carboxylic acid analogue with potent antiviral activity

It is established that drugs targeting viral proteins are at risk of generating resistant strains. However, drugs targeting host factors can potentially avoid this problem. Herein, we report structure-activity relationship studies leading to the discovery

A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase

A series of quinoline inhibitors of C. albicans prolyl tRNA synthetase was identified. The most potent analogue, 2-(4bromo-phenyl)-6-chloro-8-methyl-4-quinolinecarboxylic acid, showed IC50=5 nM (Ca. ProRS) with high selectivity over the human enzyme.