346725-04-0 Usage
Uses
Used in Pharmaceutical Synthesis:
N-(4-Methoxybenzyl) 4-fluorobenzamide is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure and reactivity make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, N-(4-Methoxybenzyl) 4-fluorobenzamide is utilized as a starting material for the design and synthesis of novel bioactive molecules. Its structural features allow for the exploration of new chemical space and the discovery of potential drug candidates with improved pharmacological properties.
Used in Drug Development:
N-(4-Methoxybenzyl) 4-fluorobenzamide may have potential applications in drug development, where its unique structural features can be leveraged to create new therapeutic agents with enhanced efficacy and selectivity. Its reactivity and compatibility with various synthetic strategies make it a valuable tool in the development of innovative pharmaceuticals.
It is crucial to handle N-(4-Methoxybenzyl) 4-fluorobenzamide with care and adhere to proper safety protocols when working with it in a laboratory setting to ensure the safety of researchers and the integrity of experiments.
Check Digit Verification of cas no
The CAS Registry Mumber 346725-04-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,6,7,2 and 5 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 346725-04:
(8*3)+(7*4)+(6*6)+(5*7)+(4*2)+(3*5)+(2*0)+(1*4)=150
150 % 10 = 0
So 346725-04-0 is a valid CAS Registry Number.
346725-04-0Relevant articles and documents
Copper(I)-Catalyzed Reductive Cross-Coupling of N-Tosylhydrazones with Amides: A Straightforward Method for the Construction of C(sp3)- N Amide Bonds from Aldehydes
Xu, Peng,Han, Fu-She,Wang, Yan-Hua
, p. 3441 - 3446 (2015)
A method for the one-pot synthesis of substituted amides from aldehydes and amides is presented. Namely, condensation of aldehydes with N-tosylhydrazide generated the N-tosylhydrazones which were then reductively cross-coupled in situ with primary or secondary amides in the presence of a copper catalyst to afford secondary or tertiary amides, respectively. The reaction proceeded efficiently for a wide range of aldehydes and amides under the optimized conditions, i.e., 10 mol% of tetrakis(acetonitrile)copper(I) tetrafluoroborate [Cu(CH3CN)4BF4], 1 mol% of tetra-n-butylammonium iodide [(n-Bu)4NI], and sodium hydroxide [NaOH] as base in tetrahydrofuran (THF) at 80 C. As a result, the method provides a straightforward route for the synthesis of substituted amides from readily available aldehydes via a transition metal-catalyzed C(sp3)- N amide bond forming reaction.
