3470-50-6 Usage
Uses
Used in Pharmaceutical Synthesis:
6-Hydroxy-1-tetralone is used as a starting material for the synthesis of various pharmaceutical compounds, including drugs with potential therapeutic applications. Its unique structure allows for the introduction of different functional groups, making it a versatile building block in medicinal chemistry.
Used in Organic Synthesis:
6-Hydroxy-1-tetralone is used as a starting material for a one-pot conversion of phenols to anilines. This reaction provides a convenient and efficient method for the synthesis of aniline derivatives, which are important intermediates in the production of various organic compounds and pharmaceuticals.
Used in the Synthesis of Specific Compounds:
6-Hydroxy-1-tetralone may be used in the synthesis of several specific compounds, such as:
1. 5-chloromethyl-6-hydroxy-3,4-dihydro-1(2H)-naphthalenone: 6-Hydroxy-1-tetralone can be used as a building block for the development of new organic compounds with potential applications in various industries.
2. 6-(4-(3-(piperidin-1-yl)propoxy)benzyloxy)-1-tetralone: 6-Hydroxy-1-tetralone may have potential applications in the pharmaceutical industry as a precursor for the development of new drugs.
3. 6-(3-(piperidin-1-yl)propoxy)-1-tetralone: 6-Hydroxy-1-tetralone can be used as an intermediate in the synthesis of various organic compounds and may have potential applications in different industries.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 41, p. 1068, 1998 DOI: 10.1021/jm970527vJournal of the American Chemical Society, 99, p. 5810, 1977 DOI: 10.1021/ja00459a052
Check Digit Verification of cas no
The CAS Registry Mumber 3470-50-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,7 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 3470-50:
(6*3)+(5*4)+(4*7)+(3*0)+(2*5)+(1*0)=76
76 % 10 = 6
So 3470-50-6 is a valid CAS Registry Number.
InChI:InChI=1/C10H10O2/c11-8-4-5-9-7(6-8)2-1-3-10(9)12/h4-6,11H,1-3H2
3470-50-6Relevant articles and documents
A photo-favorskii ring contraction reaction: The effect of ring size
Kammath, Viju Balachandran,?olomek, Tomá?,Ngoy, Bokolombe Pitchou,Heger, Dominik,Klán, Petr,Rubina, Marina,Givens, Richard S.
, p. 1718 - 1729 (2013/03/29)
The effect of ring size on the photo-Favorskii induced ring-contraction reaction of the hydroxybenzocycloalkanonyl acetate and mesylate esters (7a-d, 8a-c) has provided new insight into the mechanism of the rearrangement. By monotonically decreasing the ring size in these cyclic derivatives, the increasing ring strain imposed on the formation of the elusive bicyclic spirocyclopropanone 20 results in a divergence away from rearrangement and toward solvolysis. Cycloalkanones of seven or eight carbons undergo a highly efficient photo-Favorskii rearrangement with ring contraction paralleling the photochemistry of p-hydroxyphenacyl esters. In contrast, the five-carbon ring does not rearrange but is diverted to the photosolvolysis channel avoiding the increased strain energy that would accompany the formation of the spirobicyclic ketone, the "Favorskii intermediate 20". The six-carbon analogue demonstrates the bifurcation in reaction channels, yielding a solvent-sensitive mixture of both. Employing a combination of time-resolved absorption measurements, quantum yield determinations, isotopic labeling, and solvent variation studies coupled with theoretical treatment, a more comprehensive mechanistic description of the rearrangement has emerged.
