837373-18-9Relevant academic research and scientific papers
2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors
Chordia, Mahendra D.,Murphree, Lauren J.,Macdonald, Timothy L.,Linden, Joel,Olsson, Ray A.
, p. 1563 - 1566 (2002)
This report describes the synthesis and structure-activity relationships of a new class of A1 adenosine receptor agonist allosteric enhancers, 2-aminothiazolium salts. The EC50 of compounds 6a, 6b, 7, and 8 were 0.3, 4.5, 3.8, and 1.2 μM, substantially lower than that of the 'Gold Standard' 2-amino-3-benzoyl thiophene (PD 81,723), which has an EC50 of 38 μM.
