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TERT-BUTYL 4-BROMO-3-METHYLBENZOATE, with the molecular formula C12H15BrO2, is a white to light yellow crystalline solid. It is a versatile chemical compound commonly utilized as an intermediate in the synthesis of pharmaceutical and agrochemical products. Known for its ability to participate in various chemical reactions, TERT-BUTYL 4-BROMO-3-METHYLBENZOATE holds significant value in the realm of organic chemistry. However, it is crucial to handle TERT-BUTYL 4-BROMO-3-METHYLBENZOATE with caution due to potential hazards associated with its improper use.

347174-28-1

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347174-28-1 Usage

Uses

Used in Pharmaceutical Industry:
TERT-BUTYL 4-BROMO-3-METHYLBENZOATE is used as a synthetic intermediate for the production of various pharmaceutical products. Its versatility in undergoing different chemical reactions allows for the creation of a wide range of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, TERT-BUTYL 4-BROMO-3-METHYLBENZOATE serves as an essential intermediate in the synthesis of agrochemicals. Its reactivity contributes to the development of effective products for agricultural applications.
Used in Organic Chemical Production:
TERT-BUTYL 4-BROMO-3-METHYLBENZOATE is utilized in the production of various organic chemicals. Its role as a reagent in organic synthesis highlights its importance in creating a multitude of chemical compounds for diverse uses.
Used in Organic Synthesis as a Reagent:
As a reagent in organic synthesis, TERT-BUTYL 4-BROMO-3-METHYLBENZOATE is employed for its ability to participate in numerous chemical reactions. This quality makes it a valuable component in the synthesis of a broad spectrum of organic compounds.

Check Digit Verification of cas no

The CAS Registry Mumber 347174-28-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,7,1,7 and 4 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 347174-28:
(8*3)+(7*4)+(6*7)+(5*1)+(4*7)+(3*4)+(2*2)+(1*8)=151
151 % 10 = 1
So 347174-28-1 is a valid CAS Registry Number.

347174-28-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl 4-bromo-3-methylbenzoate

1.2 Other means of identification

Product number -
Other names Benzoic acid,4-bromo-3-methyl-,1,1-dimethylethyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:347174-28-1 SDS

347174-28-1Relevant articles and documents

An Aza-Cope Reactivity-Based Fluorescent Probe for Imaging Formaldehyde in Living Cells

Brewer, Thomas F.,Chang, Christopher J.

, p. 10886 - 10889 (2015)

Formaldehyde (FA) is a reactive carbonyl species (RCS) produced in living systems that has been implicated in epigenetics as well as in the pathologies of various cancers, diabetes, and heart, liver, and neurodegenerative diseases. Traditional methods for biological FA detection rely on sample destruction and/or extensive processing, resulting in a loss of spatiotemporal information. To help address this technological gap, we present the design, synthesis, and biological evaluation of a fluorescent probe for live-cell FA imaging that relies on a FA-induced aza-Cope rearrangement. Formaldehyde probe-1 (FAP-1) is capable of detecting physiologically relevant concentrations of FA in aqueous buffer and in live cells with high selectivity over potentially competing biological analytes. Moreover, FAP-1 can visualize endogenous FA produced by lysine-specific demethylase 1 in a breast cancer cell model, presaging the potential utility of this chemical approach to probe RCS biology.

Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties ()

Vachal, Petr,Duffy, Joseph L.,Campeau, Louis-Charles,Amin, Rupesh P.,Mitra, Kaushik,Murphy, Beth Ann,Shao, Pengcheng P.,Sinclair, Peter J.,Ye, Feng,Katipally, Revathi,Lu, Zhijian,Ondeyka, Debra,Chen, Yi-Heng,Zhao, Kake,Sun, Wanying,Tyagarajan, Sriram,Bao, Jianming,Wang, Sheng-Ping,Cote, Josee,Lipardi, Concetta,Metzger, Daniel,Leung, Dennis,Hartmann, Georgy,Wollenberg, Gordon K.,Liu, Jian,Tan, Lushi,Xu, Yingju,Chen, Qinghao,Liu, Guiquan,Blaustein, Robert O.,Johns, Douglas G.

supporting information, p. 13215 - 13258 (2021/09/02)

Cholesteryl ester transfer protein (CETP) represents one of the key regulators of the homeostasis of lipid particles, including high-density lipoprotein (HDL) and low-density lipoprotein (LDL) particles. Epidemiological evidence correlates increased HDL and decreased LDL to coronary heart disease (CHD) risk reduction. This relationship is consistent with a clinical outcomes trial of a CETP inhibitor (anacetrapib) combined with standard of care (statin), which led to a 9% additional risk reduction compared to standard of care alone. We discuss here the discovery of MK-8262, a CETP inhibitor with the potential for being the best-in-class molecule. Novel in vitro and in vivo paradigms were integrated to drug discovery to guide optimization informed by a critical understanding of key clinical adverse effect profiles. We present preclinical and clinical evidence of MK-8262 safety and efficacy by means of HDL increase and LDL reduction as biomarkers for reduced CHD risk.

HOMOALLYLAMINES AS FORMALDEHYDE-RESPONSIVE TRIGGERS

-

Paragraph 00233, (2017/03/14)

Probes for formaldehyde (FA) including a homoallylamine trigger group attached to a detectable moiety are provided. Aspects of the probes include luminogenic or fluorogenic probes, such as a probe including a quencher in energy-receiving proximity to a fl

Intracellular Protein-Labeling Probes for Multicolor Single-Molecule Imaging of Immune Receptor-Adaptor Molecular Dynamics

Sato, Ryota,Kozuka, Jun,Ueda, Masahiro,Mishima, Reiko,Kumagai, Yutaro,Yoshimura, Akimasa,Minoshima, Masafumi,Mizukami, Shin,Kikuchi, Kazuya

supporting information, p. 17397 - 17404 (2017/12/15)

Single-molecule imaging (SMI) has been widely utilized to investigate biomolecular dynamics and protein-protein interactions in living cells. However, multicolor SMI of intracellular proteins is challenging because of high background signals and other lim

BICYCLOHETEROARYL-HETEROARYL-BENZOIC ACID COMPOUNDS AS RETINOIC ACID RECEPTOR BETA (RARβ) AGONISTS

-

Page/Page column 105; 106, (2016/07/05)

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain bicycloheteroaryl-heteroaryl-benzoic acid compounds of the following formula (for convenience, collectively referred to herein as "BHBA compou

Silicon and germanium dyes for use in genetic identity

-

, (2015/11/16)

Si- and Ge-based dyes and methods of using same.

Aarhus green: A tetrafluoro-substituted derivative of fluorescein

Holmehave, Jeppe,Pedersen, Stephan K.,Jensen, Henrik H.,Ogilby, Peter R.

, p. 52 - 64 (2015/03/31)

The synthesis and characterization of a 2′,4′,5′,7′-tetrafluorinated derivative of fluorescein, called Aarhus Green, is reported. As with related 2′,7′-difluorinated compounds, tetrafluorination of the xanthene-derived moiety makes the more fluorescent anion accessible over a larger pH range. However, in contrast to a published report, we find that fluorination in the 4′ and 5′ positions does not appreciably decrease the fluorescence quantum yield, φf. Rather, Aarhus Green has a reasonably large φf (0.79 ± 0.04). Moreover, Aarhus Green does not efficiently sensitize the production of singlet oxygen and it is photostable. Thus, tetrafluorination of the xanthene moiety in fluorescein derivatives can be a useful tool in the development of fluorescent probes.

BICYCLIC UREAS AND THIADIAZOLIDINE-1,1-DIOXIDES AS CETP INHIBITORS

-

Page/Page column 40, (2015/02/25)

Compounds having the structure of Formula I, including pharmaceutically acceptable salts of the compounds, wherein X is -C(=O) or -S(O)2-, are CETP inhibitors and are useful for raising HDL-cholesterol, reducing LDL-cholesterol, and for treating or preventing atherosclerosis.

A Cu-free clickable fluorescent probe for intracellular targeting of small biomolecules

Yamagishi, Kento,Sawaki, Kazuaki,Murata, Atsushi,Takeoka, Shinji

supporting information, p. 7879 - 7882 (2015/05/05)

We synthesized a novel cyclooctyne-based clickable fluorescent probe with versatile properties such as high cell-membrane permeability and free diffusibility in the cell. Our probe "FC-DBCO" was conjugated to an azide-modified mannose via a Cu-free click

Cell Permeable, Fluorescent Dye

-

Paragraph 0128-0131, (2014/12/09)

The invention pertains to a near-infrared fluorescent dye that is cell permeable and can be attached to selected proteins in living cells. The dye has the general formula or its corresponding spirolactone wherein Y is chosen from the group consisting of S

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