35432-36-1

Basic information

• Product Name: Isobutanesulfonyl chloride
• Synonyms: ISOBUTANESULFONYL CHLORIDE 97;2-Methylpropane-1-sulfonyl chloride;Isobutanesulfonyl chloride;2-Methyl-1-propanesulfonyl chloride;Isobutylsulfonyl chloride;Isobutanesulfonyl chloride 97%;1-Propanesulfonylchloride, 2-methyl-
• CAS NO: 35432-36-1
• Molecular Formula: C₄H₉ClO₂S
• Molecular Weight: 156.63
• Mol File: 35432-36-1.mol

Chemical Properties

• Melting Point: 95 °C(Solv: pentane (109-66-0))
• Boiling Point: 190°C
• Flash Point: 190 °F
• Appearance: Colorless/Liquid
• Density: 1.200 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.767mmHg at 25°C
• Refractive Index: n20/D 1.454(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: Isobutanesulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Isobutanesulfonyl chloride(35432-36-1)
• EPA Substance Registry System: Isobutanesulfonyl chloride(35432-36-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: Ⅱ
• Hazardous Substances Data: 35432-36-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Isobutanesulfonyl chloride is used as a key intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
It serves as a precursor in the production of agrochemicals, specifically in the creation of sulfonylurea herbicides, which are essential for effective weed control in agricultural settings.
Used in Specialty Chemicals Industry:
Isobutanesulfonyl chloride is utilized as a sulfonylating agent in the synthesis of specialty chemicals, enhancing the properties and applications of these compounds in various industrial processes.
Used in Organic Synthesis:
As a sulfonylating agent, isobutanesulfonyl chloride is used for the introduction of sulfonyl groups onto other molecules, which can improve their reactivity, stability, or other chemical properties in organic synthesis processes.

InChI:InChI=1/C4H9ClO2S/c1-4(2)3-8(5,6)7/h4H,3H2,1-2H3

Upstream product

• 75-28-5 Isobutane 
• 56-23-5 tetrachloromethane 
• 7782-50-5 chlorine 
• 1518-72-5 diisobutyl disulfide 
• 27846-15-7 sodium isobutylsulfonate 
• 513-44-0 2-methylpropanethiol-1 
• 591-84-4 isobutyl thiocyanate 

Downstream Products

• 740873-27-2 2-methylpropane-1-sulfonic acid methyl-{4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide 
• 896125-11-4 2-methylpropane-1-sulfonic acid {4-[4-(3-nitrophenyl)piperazin-1-yl]butyl}amide 
• 91717-09-8 N-(2-methyl-propane-1-sulfonyl)-sulfanilic acid amide 

Relevant articles and documents

A new synthesis of alkane and polyfluoroalkanesulfonyl chlorides

This study describes a new and advantageous procedure for the synthesis of alkanesulfonyl chlorides (2) by the reaction of alkyl thiocyanates (1) with sulfuryl chloride in a mixture of acetic acid and water. The alkanesulfonyl chlorides were obtained in good yields.

Sulphonamido-Substituted Cyclohexyl Sulphones for Treatment of Cancer

Compounds of formula (I) are disclosed for treatment of cancer.

(BIS)sulfonamide derivatives

The present invention provides (bis) sulfonamide derivatives of formula (I) useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

CYCLOHEXYL SULPHONES AS GAMMA-SECRETASE INHIBITORS

Compounds of formula (I) inhibit the processing of APP by gamma-secretase, and hence are useful in treating or preventing Alzheimer's disease.

N-substituted sulfonamide derivatives

The present invention provides certain N-substituted sulfonamide derivatives useful for potentiating glutamate receptor function in a mammal and therefore, useful for treating a wide variety of conditions, such as psychiatric and neurological disorders.

Sulphonamide derivatives

Glutamate receptor function in a mammal may be potentiated using an effective amount of a compound of formulaR1—L—NHSO2R2??Iin whichR1 represents an unsubstituted or substituted aromatic or heteroaromatic group;R2 represents (1-6C)alkyl, (3-6C)cycloalkyl, (1-6C)fluoroalkyl, (1-6C)chloroalkyl, (2-6C)alkenyl, (1-4C)alkoxy(1-4C)alkyl, phenyl which is unsubstituted or substituted by halogen, (1-4C)alkyl or (1-4C)alkoxy, or a group, of formula R3R4N in which R3 and R4 each independently represents (1-4C)alkyl or, together with the nitrogen atom to which they are attached form an azetidinyl, pyrrolidinyl, piperidinyl, morpholino, piperazinyl, hexahydroazepinyl or octahydroazocinyl group; andL represents a (2-4C)alkylene chain which is unsubstituted or substituted by one or two substituents selected independently from (1-6C)alkyl, aryl(1-6C)alkyl, (2-6C)alkenyl, aryl(2-6C)alkenyl and aryl, or by two substituents which, together with the carbon atom or carbon atoms to which they are attached form a (3-8C)carbocyclic ring;and pharmaceutically acceptable salts thereof.Also disclosed are compounds of formula I, processes for preparing them and pharmaceutical compositions containing them.

Preparation of sulfonamides from sodium sulfonates: Ph3P·Br2 and Ph3P·Cl2 as a mild halogenating reagent for sulfonyl bromides and sulfonyl chlorides

Arene- and alkanesulfonamides were prepared by treatment of the corresponding sodium sulfonates with triphenylphosphine dibromide or dichloride followed by amines in the presence of triethylamine via sulfonyl halides. Reactions of sodium aminosulfonates gave cyclized products. Amidation of p-toluenesulfonic acid with triphenylphosphine dichloride was also examined to give N-benzyl-p-toluenesulfonamide. Methyl p- toluenesulfonate was obtained by esterification of sodium p-toluenesulfonate via p-toluenesulfonyl chloride.

LEUKOTRIENE-INHIBITING SUBSTITUTED (QUINOLIN-2-YL-METHOXY)PHENYL-N,N'-SULPHONYLUREAS AND USE THEREAS

Lipoxygenase-inhibiting and leukotriene-inhibiting substituted (quinolin-2-yl-methoxy)phenyl-N,N'-sulphonylureas of the formula and physiologically acceptable salts thereof

N-sulfonyl-N-dihalophenylimidazolidinediones

3-(3' -Dihalophenyl)-1-sulfonylimidazolidine-2,4-5'-diones of the formula: STR1 wherein X is a halogen atom, R1 is a C1 -C12 alkyl group, a C2 -C4 alkenyl group or a halogenated C1 -C4 alkyl group having 1 to 3 halogen atoms, and R2 and R3 are individually a hydrogen atom or a methyl group, which show high microbicidal activities against various fungi and bacteria without any material toxicity to mammals and which plants and can be produced by reacting the corresponding 1-unsubstituted compound with a sulfonyl halide.