356782-33-7

Basic information

• Product Name: 6-CARBOXYL-4-PHENYL-3,4-DIHYDROCOUMARIN
• Synonyms: 3,4-Dihydro-2-oxo-4-phenyl-2H-1-benzopyran-6-carboxylic Acid;6-CARBOXYL-4-PHENYL-3,4-DIHYDROCOUMARIN
• CAS NO: 356782-33-7
• Molecular Formula: C₁₆H₁₂O₄
• Molecular Weight: 268.26408
• Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals;Aromatics Compounds;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 356782-33-7.mol

Chemical Properties

• Boiling Point: 434.564°C at 760 mmHg
• Flash Point: 164.15°C
• Appearance: /
• Density: 1.338g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.632
• Storage Temp.: Refrigerator
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 6-CARBOXYL-4-PHENYL-3,4-DIHYDROCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CARBOXYL-4-PHENYL-3,4-DIHYDROCOUMARIN(356782-33-7)
• EPA Substance Registry System: 6-CARBOXYL-4-PHENYL-3,4-DIHYDROCOUMARIN(356782-33-7)

Safety Data

• Hazardous Substances Data: 356782-33-7(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
6-Carboxyl-4-phenyl-3,4-dihydrocoumarin is used as a key intermediate in the synthesis of various organic compounds. Its unique structure and functional groups allow it to participate in a wide range of chemical reactions, making it a versatile building block for the creation of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 6-Carboxyl-4-phenyl-3,4-dihydrocoumarin is used as a starting material for the development of new drugs. Its chemical properties and reactivity make it a promising candidate for the synthesis of novel therapeutic agents, particularly those targeting specific biological pathways or receptors.
Used in Chemical Research:
6-Carboxyl-4-phenyl-3,4-dihydrocoumarin is also utilized in chemical research as a model compound for studying various reaction mechanisms and exploring new synthetic routes. Its unique structure and properties provide valuable insights into the behavior of similar compounds and contribute to the advancement of chemical knowledge.
Used in Material Science:
In the field of material science, 6-Carboxyl-4-phenyl-3,4-dihydrocoumarin may be used as a component in the development of new materials with specific properties. Its chemical structure and reactivity can be exploited to create materials with tailored characteristics, such as improved stability, enhanced reactivity, or unique optical properties.
Used in Agrochemical Industry:
6-Carboxyl-4-phenyl-3,4-dihydrocoumarin can also be employed in the agrochemical industry as a building block for the synthesis of new pesticides or other agricultural chemicals. Its unique chemical properties may contribute to the development of more effective and environmentally friendly products for crop protection and management.

InChI:InChI=1/C16H12O4/c17-15-9-12(10-4-2-1-3-5-10)13-8-11(16(18)19)6-7-14(13)20-15/h1-8,12H,9H2,(H,18,19)

Upstream product

• 621-82-9 Cinnamic acid 
• 99-96-7 4-hydroxy-benzoic acid 
• 140-10-3 (E)-3-phenylacrylic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 

Downstream Products

• 380636-41-9 (R,S)-4-phenyl-2-chromanone-6-carbonyl chloride 
• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 286930-02-7 fesoterodine 
• 286930-03-8 fesoterodine fumarate 
• 156755-20-3 PNU 200577 l-mandelate salt 
• 1390644-34-4 isobutyric acid 2-((R)-3-diisopropylammonium-1-phenyIpropyl)-4-(hydroxymethyl)phenyl ester (R)-acetoxy(phenyl)acetate 
• 1390644-38-8 (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenylmethacrylate mandelate 
• 1390644-37-7 (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxylmethyl)phenyl methacrylate 
• 1203453-91-1 (R)-2-(3-amino-1-phenylpropyl)-4-(hydroxymethyl)phenol 
• 1390644-50-4 (R)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenyl-2-bromo-2-methyl propanoate 
• 1390644-52-6 2-((R)-3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyi)phenyl-3-bromo-2-methyl propanoate 
• 960373-30-2 (R)-6-hydroxymethyl-4-phenylchroman-2-(RS)-ol 
• 960373-32-4 (R)-4-phenyl-2-chromanone-6-carbonyl chloride 
• 380636-39-5 (R)-4-phenyl-2-chromanone-6-carboxylic acid 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF MUSCARINIC RECEPTOR ANTAGONIST

The present invention relates to novel and improved processes for the preparation of (r)-2-(3-(diisopropylamino)-1-phenylpropyl)-4-(hydroxymethyl)phenylisobutyrate represented by the following structural formula-1 and its pharmaceutically acceptable salts thereof.

NEW CHIRAL INTERMEDIATE, PROCESS FOR PRODUCING THE SAME AND ITS USE IN THE MANUFACTURE OF TOLTERODINE, FESOTERODINE, OR THE ACTIVE METABOLITE THEREOF

The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.

Shortened synthesis of 3,3-diarylpropylamine derivatives

The invention relates to a method for producing derivatives of 3,3-diarylpropylamines of general formula (I) and sterically highly pure, stable intermediate products, and to their use for producing pharmaceutical compositions.