356783-26-1

Basic information

• Product Name: 3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester
• Synonyms: 3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester
• CAS NO: 356783-26-1
• Molecular Formula: C6H4F2N2O2
• Molecular Weight: 174.1049664
• Mol File: 356783-26-1.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester(356783-26-1)
• EPA Substance Registry System: 3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester(356783-26-1)

Safety Data

• Hazardous Substances Data: 356783-26-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester is utilized as a precursor in the production of agricultural chemicals, enhancing the effectiveness of pesticides and other crop protection agents.
Used in Organic Synthesis:
3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester is employed as a building block in organic synthesis, facilitating the creation of heterocyclic compounds that have potential applications in various fields.
Used in Material Development:
3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester is also used in the development of new materials, leveraging its chemical properties to contribute to advancements in material sciences.
Used as a Research Tool:
3,6-Difluoro-pyrazine-2-carboxylic acid Methyl ester serves as an important research tool in various scientific disciplines, aiding in the exploration of new chemical reactions and the discovery of novel compounds.

Upstream product

• 79-37-8 oxalyl dichloride 
• 356783-15-8 3,6-dichloro-2-pyrazinecarboxylic acid 
• 356783-14-7 methyl 3,6-dichloro-2-pyrazinecarboxylate 
• 16298-03-6 Methyl 3-amino-2-pyrazinecarboxylate 
• 1458-03-3 3-amino-6-chloropyrazine-2-carboxylic acid methyl ester 
• 616-38-6 carbonic acid dimethyl ester 

Downstream Products

• 356783-27-2 methyl 6-fluoro-3-oxo-3,4-dihydro-2-pyrazinecarboxylate 
• 259793-96-9 favipiravir 
• 356783-29-4 3,6-difluoropyrazine-2-carboxamide 

Relevant articles and documents

METHODS FOR PREPARING FAVIPIRAVIR

The present invention provides methods for preparing Favipiravir (6-fluoro-3-hydroxypyrazine-2-carboxamide).

Synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid

The invention belongs to medical intermediates, and particularly relates to a synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid. The 6-fluoro-3-hydroxypyrazine-2-carboxylic acid is prepared by taking a compound A, namely 3-aminopyrazine-2-carboxylic acid methyl ester as an initial raw material through five-step reaction, the synthetic method of the 6-fluoro-3-hydroxypyrazine-2-carboxylic acid is provided, a synthetic route is provided for the synthetic method of the 6-fluoro-3-hydroxypyrazine-2-carboxylic acid, the synthesis method of 6-fluoro-3-hydroxypyrazine-2-carboxylic acid provided by the invention is reasonable in design, simple to operate and easy to control, and meanwhile, the product obtained by the invention is relatively high in yield.

Novel pyrazine derivatives or salts thereof, pharmaceutical composition containing the same, and production intermediates thereof

Pyrazine derivatives represented by general formula [1]: 1wherein the variables are as defined in the specification, or salts thereof have an excellent antiviral activity and are useful as a therapeutic agent for treating viral infections. Further, fluoropyrazine-carboxamide derivatives represented by general formula [2]: 2wherein the variables are as defined in the specification, or salts thereof are useful as an intermediate for production of the compounds of general formula [1], and as an intermediate for production of the fluoropyrazine-carboxamide derivatives of which one typical example is 6-fluoro-3-hyroxy-2-pyrazine-carboxamide having an antiviral activity.