- NOVEL TRIFLUOROMETHYL-OXADIAZOLE DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
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The invention relates to novel trifluoromethyl-oxadiazole derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, pharmaceutical com
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Page/Page column 68
(2013/06/27)
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- PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS
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The present invention relates to 6-(piperidin-4-ylamino)pyridazin-3-carbonitriles of formula (I) that are fast dissociating dopamine 2 receptor antagonists, processes for preparing these compounds, pharmaceutical compositions comprising these compounds as an active ingredient. The compounds find utility as medicines for treating or preventing central nervous system disorders, for example schizophrenia, by exerting an antipsychotic effect without motor side effects.
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Page/Page column 18-19
(2008/12/06)
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- Discovery of potent, selective, orally bioavailable stearoyl-CoA desaturase 1 inhibitors
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Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in the biosynthesis of monounsaturated fatty acids from saturated, long-chain fatty acids. Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin
- Liu, Gang,Lynch, John K.,Freeman, Jennifer,Liu, Bo,Xin, Zhili,Zhao, Hongyu,Serby, Michael D.,Kym, Philip R.,Suhar, Tom S.,Smith, Harriet T.,Cao, Ning,Yang, Ruojing,Janis, Rich S.,Krauser, Joel A.,Cepa, Steven P.,Beno, David W. A.,Sham, Hing L.,Collins, Christine A.,Surowy, Teresa K.,Camp, Heidi S.
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p. 3086 - 3100
(2008/02/10)
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- Aromatic compounds and pharmaceutical compositions containing them
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The invention relates to compounds of formula I and pharmaceutically acceptable salts and in vivo hydrolysable esters and amides thereof and processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.
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- Fungicidal pyridazines
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Plants are protected from the damaging effects of Phycomycetous fungi by a series of pyridazines of formula STR1 wherein R3 is chloro, bromo, methyl, cyano or iodo; R is chloro, bromo, iodo, methyl, cyano or furan-2-ylmethoxy; R1 is
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- Synthesis and antihypertensive activity of novel 6-substituted-3-pyridazinylhydrazones
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The synthesis and hypotensive properties of a series of 6-substituted-3-pyridazinylhydrazones are described. The most active compound of the series. 1-(6-morpholino-3-pyridazinyl)-2-[1-(tert-butoxycarbonyl)-2-propylidene] hydrazine, is a more potent hypotensive agent than hydralazine with a longer duration of action and a lower toxicity. Structure-activity relationships are discussed.
- Szilagyi,Kasztreiner,Matyus,et al.
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p. 111 - 117
(2007/10/02)
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