Quinine-catalyzed enantioselective desymmetrization of meso-aziridines with benzenethiols
Ring opening of meso-aziridines with benzenethiols utilizing quinine as an organocatalyst has been developed. The reaction proceeded smoothly in the presence of 10 mol % of quinine in CHCl3 to afford β-amino sulfides in high yields and with mod
Wang, Zhiyong,Sun, Xiaoyu,Ye, Shengqing,Wang, Weizi,Wang, Bing,Wu, Jie
Tributylphosphine: A remarkable promoting reagent for the ring-opening reaction of aziridines
Tributylphosphine was found to be an effective promoting reagent for ring opening of a variety of aziridines and nucleophiles to produce anti-bifunctional products in good to excellent yield. The study showed that the reaction is initiated through the attack of tributylphosphine as a nucleophile at the carbon atom of the aziridine ring.
Bismuth triflate as novel and efficient catalyst for the synthesis of β-aminosulfides
Aziridines undergo ring opening readily with various thiols in the presence of 5 mol% bismuth triflate under very mild reaction conditions to afford the corresponding β-aminosulfides in excellent yields with high regioselectivity.
Yadav, Jhillu S.,Reddy, B. V. Subba,Baishya, Gakul,Reddy, P. Venkatram,Harshavardhan
Polyethylene glycol (PEG) as an efficient recyclable medium for the synthesis of β-amino sulfides
Aziridines undergo ring opening readily with various thiols in the presence of polyethylene glycol (PEG) to afford the corresponding β-amino sulfides in high yields with good regioselectivity under mild and neutral conditions. The PEG can be recovered and