35982-99-1 Usage
Uses
Used in Pharmaceutical Industry:
2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the formation of pyridine derivatives, which have diverse applications in medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE serves as a precursor in the production of pyridine-based pesticides and herbicides, leveraging its structural properties to enhance the effectiveness of these products.
Used in Organic Synthesis:
2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE is utilized as a building block in organic synthesis, allowing for the creation of a variety of organic compounds through its reactive sites.
Used as a Chemical Intermediate:
2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE is also employed as an intermediate in the synthesis of other organic compounds, highlighting its importance in the broader scope of chemical manufacturing and research.
It is crucial to handle 2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE with care due to its potential toxicity and harmful effects if mismanaged, ensuring proper safety measures are in place throughout its use and disposal.
Check Digit Verification of cas no
The CAS Registry Mumber 35982-99-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,9,8 and 2 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 35982-99:
(7*3)+(6*5)+(5*9)+(4*8)+(3*2)+(2*9)+(1*9)=161
161 % 10 = 1
So 35982-99-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H6Cl2N2/c13-11-3-1-8(2-4-11)10-5-9(6-15)12(14)16-7-10/h1-5,7H
35982-99-1Relevant articles and documents
Design, synthesis, and activity of a series of arylpyrid-3-ylmethanones as type i positive allosteric modulators of α7 nicotinic acetylcholine receptors
Hogenkamp, Derk J.,Ford-Hutchinson, Thomas A.,Li, Wen-Yen,Whittemore, Edward R.,Yoshimura, Ryan F.,Tran, Minhtam B.,Johnstone, Timothy B. C.,Bascom, Gavin D.,Rollins, Hannah,Lu, Lena,Gee, Kelvin W.
, p. 8352 - 8365 (2013/12/04)
A series of novel arylpyrid-3-ylmethanones (7a-aa) were designed as modulators of α7 nicotinic acetylcholine receptors (nAChRs). The methanones were found to be type I positive allosteric modulators (PAMs) of human α7 nAChRs expressed in Xenopus ooctyes. Structure-activity relationship (SAR) studies resulted in the identification of compound 7v as a potent and efficacious type I PAM with maximum modulation of a nicotine EC 5 response of 1200% and EC50 = 0.18 μM. Compound 7z was active in reversing the effect of scopolamine in the novel object recognition (NOR) paradigm with a minimum effective ip dose of 1.0 mg/kg (2.7 μmol/kg). This effect was blocked by the selective α7 nAChR antagonist methyllycaconitine (MLA). These compounds are potent type I positive allosteric modulators of α7 nAChRs that may have therapeutic value in restoring impaired sensory gating and cognitive deficits in schizophrenia and Alzheimer's disease.
1-Benzoyl-3-(arylphyridyl)urea compounds
-
, (2008/06/13)
The present invention is directed to 1-benzoyl-3-(arylpyridyl)urea compounds useful as insecticides.
