360-54-3

Basic information

• Product Name: METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE
• Synonyms: METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPANOATE;METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE;hexafluoro-isobutyricacimethylester;methyl3,3,3-trifluoro-2-(trifluoromethyl)propionate;methylhexafluoroisobutyrate;Methyl 2-(trifluoromethyl)-3,3,3-trifluoro-;3,3,3-Trifluoro-2-(trifluoromethyl)propionic acid methyl ester;3,3,3-Trifluoro-2-trifluoromethylpropionic acid methyl ester
• CAS NO: 360-54-3
• Molecular Formula: C₅H₄F₆O₂
• Molecular Weight: 210.07
• Mol File: 360-54-3.mol

Chemical Properties

• Boiling Point: 90-91°C
• Flash Point: 60°C
• Appearance: /
• Density: 1.604
• Vapor Pressure: 48.6mmHg at 25°C
• Refractive Index: 1.269
• CAS DataBase Reference: METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE(360-54-3)
• EPA Substance Registry System: METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE(360-54-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 16-26-36/37/39
• RIDADR: 3272
• RTECS: NQ4690000
• HazardClass: 3/6.1
• PackingGroup: II
• Hazardous Substances Data: 360-54-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE is used as a reagent in organic synthesis for its ability to participate in a range of chemical reactions, enabling the creation of diverse compounds with specific applications.
Used in Pharmaceutical Production:
In the pharmaceutical industry, METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE is utilized as a building block in the development of new drugs, contributing to the synthesis of medicinal compounds that address various health conditions.
Used in Agrochemical Production:
Similarly, in agrochemical manufacturing, METHYL 2-(TRIFLUOROMETHYL)-3,3,3-TRIFLUOROPROPIONATE serves as a key component in the synthesis of products designed to protect and enhance crop yields, manage pests, and improve agricultural practices.
Each application takes advantage of the compound's unique reactivity and properties to fulfill specific needs within their respective fields.

InChI:InChI=1/C5H4F6O2/c1-13-3(12)2(4(6,7)8)5(9,10)11/h2H,1H3

Upstream product

• 382-26-3 1,1,1,3,3-pentafluoro-3-methoxy-2-trifluoromethylpropane 
• 67-56-1 methanol 
• 684-36-6 perfluoromethacryloyl fluoride 
• 684-22-0 bis(trifluoromethyl)ketene 
• 17530-33-5 5.5-Bis-(trifluor-methyl)-2-methyl-4--pentadien-(1.4) 
• 63616-72-8 Potassium; 3,3,3-trifluoro-2-trifluoromethyl-propionate 
• 77-78-1 dimethyl sulfate 
• 360-53-2 1,3,3,3-tetrafluoro-1-methoxy-2-trifluoromethyl-propene 

Downstream Products

• 5838-00-6 methyl dimethyl 2-(trifluoromethyl)propanedioate 
• 18830-44-9 methyl 3,3,3-trifluoropropionate 
• 67732-81-4 3,3,3-Trifluoro-2-phenylsulfanyl-2-trifluoromethyl-propionic acid methyl ester 
• 420-56-4 trimethylsilyl fluoride 
• 107887-63-8 (E)-3-Fluoro-3-morpholin-4-yl-2-trifluoromethyl-acrylic acid methyl ester 
• 107887-65-0 (E)-3-Fluoro-3-methylamino-2-trifluoromethyl-acrylic acid methyl ester 
• 455-32-3 benzoyl fluoride 
• 58932-91-5 (E)-3-Diethylamino-3-fluoro-2-trifluoromethyl-acrylic acid methyl ester 
• 384807-19-6 methyl 2-fluoroformyl-2-trifluoromethyl-3-phenyl-4-pentenoate 
• 399557-58-5 β,β-bis(benzylthio)trifluoromethacrylate 
• 618446-09-6 2-(2,4-dinitro-phenyl)-3,3,3-trifluoro-2-trifluoromethyl-propionic acid methyl ester 
• 1440140-40-8 (E)-methyl 5-phenyl-2,2-bis(trifluoromethyl)pent-4-enoate 
• 1440140-42-0 (E)-methyl 5-(4-(tert-butyl)phenyl)-2,2-bis(trifluoromethyl)pent-4-enoate 
• 1440140-44-2 (E)-methyl 5-(4-methoxyphenyl)-2,2-bis(trifluoromethyl)pent-4-enoate 

Relevant articles and documents

Dehydration of 2-Trifluoromethyl-3,3,3-trifluoropropanol with Base

2-Trifluoromethyl-3,3,3-trifluoropropanol gave 2-trifluoromethyl-3,3,3-trifluoroprop-1-ene in good yield by the action of base under mild conditions.

Preparation method of hexafluoroisobutene

The invention discloses a preparation method of hexafluoroisobutene, comprising the steps of (1) reacting heptafluoroisobutene methyl ether, methanol and a halide in type I solvent, cooling after reacting, filtering, rectifying the filtrate to obtain methyl hexafluoroisobutyrate; (2) allowing the methyl hexafluoroisobutyrate of step (1) to react with a reducing agent in type II solvent, quenching with hydrochloric acid after reacting, filtering, rectifying the filtrate to obtain hexafluoroisobutanol; (3) allowing the hexafluoroisobutanol of step (2) to react with an alkali in a molar ratio of 1:(1-10) in type III solvent, collecting the reaction product, and rectifying to obtain finished hexafluoroisobutene. The preparation method has the advantages that the process is simple, the yield is high, the raw materials are low in price and easy to obtain and the preparation method is suitable for industrialization.

Fluorine-containing compounds, and their preparation and use

Process for preparing 2-trifluoro-methyl-3,3,3-trifluoropropene.

α-Fluoroalkyl carboxylic acid esters and process for preparing the same

An α-fluoroalkyl carboxylic acid ester of the general formula STR1 wherein A is R1 R2 COR3 -- or R4 CO--, wherein R1 and R2 are independently hydrogen, alkyl, alkoxyl or phenyl, with or without the formation of a common ring therebetween, R3 is hydrogen or alkyl, R4 and R are independently alkyl, and Rf is fluoroalkyl. The α-fluoroalkyl carboxylic acid ester is prepared by reacting a fluoroalkyl silyl ketene acetal of the formula STR2 wherein R' is alkyl and Rf and R are the same as defined above, with the corresponding acetal, ketone or acyl halide.