- Cu-Catalyzed Three-Component Cascade Annulation Reaction: An Entry to Functionalized Pyridines
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A concise copper-catalyzed N-O bond cleavage/C-C/C-N bond formation procedure has been described for the synthesis of multisubstituted pyridines. Various oxime acetates, activated methylene compounds, and a wide range of aldehydes bearing aryl, heteroaryl, vinyl, and trifluoromethyl groups were employed to provide the tri- or tetrasubstituted pyridines with flexible substitution patterns. Moreover, this method features inexpensive catalysts, no need for extra oxidant, and high step-enconomy, which make it pratical and attractive.
- Jiang, Huanfeng,Yang, Jidan,Tang, Xiaodong,Li, Jianxiao,Wu, Wanqing
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p. 8763 - 8771
(2015/09/15)
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- Microwave assisted synthesis of 6-aryl-2-methyl-3-[benzothiazinylpyridinyl / 2-aminopyrimidinyl / 2-aminothiazolyl / triazolothiadiazinyl]pyridines
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A number of new 6-Aryl-2-methyl-3-[benzothiazinylpyridinyl / 2-amino pyrimidinyl / 2-aminothiazolyl and triazolothiadiazinyl] pyridines (4 - 7) have been synthesized under microwave irradiation conditions.
- Ashok,Pallavi,Reddy, G. Jagath,Rao, K. Srinivasa
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- A highly efficient regioselective one-pot synthesis of 2,3,6-trisubstituted pyridines and 2,7,7-trisubstituted tetrahydroquinolin-5-ones using K5CoW12O40·3H2O as a heterogeneous recyclable catalyst
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A systematic investigation into the regioselective one-pot, three-component condensation of enaminones 1a-g, β-dicarbonyl compounds 2a-c, and ammonium acetate in the presence of a catalytic amount of K5CoW12O40·3H2O (0.01 equiv or 1.0 mol %) under solvent free conditions, as well as in refluxing isopropanol, has been reported. The reaction was highly efficient to produce 2,3,6-trisubstituted pyridines 3a-g, 4a-g, and novel 2,7,7-trisubstituted-5,6,7,8-tetrahydroquinoline-5-ones 5a-g in excellent yields. The present procedure offers advantages of short reaction time, simple work-up, and the catalyst exhibited remarkable reusable activity.
- Kantevari, Srinivas,Chary, Mahankhali Venu,Vuppalapati, Srinivasu V.N.
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p. 13024 - 13031
(2008/03/14)
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- Enaminones in heterocyclic synthesis: A new regioselective synthesis of 2,3,6-trisubstituted pyridines, 6-substituted-3-aroylpyridines and 1,3,5-triaroylbenzenes
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1-Substituted-3-dimethylaminopropenones 1a-d reacted with acetylacetone and with ethyl acetoacetate to yield regioselectively 2,3,6-trisubstituted pyridines. Refluxing 1a-d in acetic acid/ammonium acetate resulted in the formation of 6-substituted-3-aroylpyridines, whereas refluxing in acetic acid alone afforded 1,3,5-triaroylbenzene.
- Al-Saleh, Balkis,Abdelkhalik, Mervat Mohammed,Eltoukhy, Afaf Mohammed,Elnagdi, Mohammed Hilmy
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p. 1035 - 1038
(2007/10/03)
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