36175-15-2

Usage

Type of compound

Chemical compound

Derivative of

Pyridine (a heterocyclic compound)

Presence in nature

Commonly found in plants

Type of structure

Ketone (carbonyl group attached to a six-membered aromatic ring)

Unique features

Chlorophenyl group and a methyl group on the pyridine ring

Potential applications

Pharmaceuticals, agrochemicals, material science, and organic synthesis

Further research

Necessary to fully understand potential uses and properties

Upstream product

• 50-00-0 formaldehyd 
• 184849-67-0 1-(4-chlorophenyl)ethanone O-acetyl oxime 
• 123-54-6 acetylacetone 
• 28587-05-5 3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one 
• 67382-35-8 (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one 

Downstream Products

• 1001890-95-4 C₁₄H₁₁BrClNO 

Relevant academic research and scientific papers

Cu-Catalyzed Three-Component Cascade Annulation Reaction: An Entry to Functionalized Pyridines

A concise copper-catalyzed N-O bond cleavage/C-C/C-N bond formation procedure has been described for the synthesis of multisubstituted pyridines. Various oxime acetates, activated methylene compounds, and a wide range of aldehydes bearing aryl, heteroaryl, vinyl, and trifluoromethyl groups were employed to provide the tri- or tetrasubstituted pyridines with flexible substitution patterns. Moreover, this method features inexpensive catalysts, no need for extra oxidant, and high step-enconomy, which make it pratical and attractive.

Microwave assisted synthesis of 6-aryl-2-methyl-3-[benzothiazinylpyridinyl / 2-aminopyrimidinyl / 2-aminothiazolyl / triazolothiadiazinyl]pyridines

A number of new 6-Aryl-2-methyl-3-[benzothiazinylpyridinyl / 2-amino pyrimidinyl / 2-aminothiazolyl and triazolothiadiazinyl] pyridines (4 - 7) have been synthesized under microwave irradiation conditions.

A highly efficient regioselective one-pot synthesis of 2,3,6-trisubstituted pyridines and 2,7,7-trisubstituted tetrahydroquinolin-5-ones using K5CoW12O40·3H2O as a heterogeneous recyclable catalyst

A systematic investigation into the regioselective one-pot, three-component condensation of enaminones 1a-g, β-dicarbonyl compounds 2a-c, and ammonium acetate in the presence of a catalytic amount of K5CoW12O40·3H2O (0.01 equiv or 1.0 mol %) under solvent free conditions, as well as in refluxing isopropanol, has been reported. The reaction was highly efficient to produce 2,3,6-trisubstituted pyridines 3a-g, 4a-g, and novel 2,7,7-trisubstituted-5,6,7,8-tetrahydroquinoline-5-ones 5a-g in excellent yields. The present procedure offers advantages of short reaction time, simple work-up, and the catalyst exhibited remarkable reusable activity.

Enaminones in heterocyclic synthesis: A new regioselective synthesis of 2,3,6-trisubstituted pyridines, 6-substituted-3-aroylpyridines and 1,3,5-triaroylbenzenes

1-Substituted-3-dimethylaminopropenones 1a-d reacted with acetylacetone and with ethyl acetoacetate to yield regioselectively 2,3,6-trisubstituted pyridines. Refluxing 1a-d in acetic acid/ammonium acetate resulted in the formation of 6-substituted-3-aroylpyridines, whereas refluxing in acetic acid alone afforded 1,3,5-triaroylbenzene.