362606-11-9

Basic information

• Product Name: 8-Isoquinolinecarbonitrile(9CI)
• Synonyms: 8-Isoquinolinecarbonitrile(9CI);isoquinoline-8-carbonitrile;8-Cyanoisoquinoline;8-Cyanoisoquinoline, 8-Cyano-2-azanaphthalene
• CAS NO: 362606-11-9
• Molecular Formula: C₁₀H₆N₂
• Molecular Weight: 154.17
• EINECS: 604-604-1
• Product Categories: ISOQUINOLINE
• Mol File: 362606-11-9.mol

Chemical Properties

• Boiling Point: 341.5oC at 760 mmHg
• Flash Point: 119.8oC
• Appearance: /
• Density: 1.21g/cm3
• Vapor Pressure: 8.03E-05mmHg at 25°C
• Refractive Index: 1.654
• Storage Temp.: 2-8°C
• PKA: 3.89±0.23(Predicted)
• CAS DataBase Reference: 8-Isoquinolinecarbonitrile(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Isoquinolinecarbonitrile(9CI)(362606-11-9)
• EPA Substance Registry System: 8-Isoquinolinecarbonitrile(9CI)(362606-11-9)

Safety Data

• Hazardous Substances Data: 362606-11-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Drug Development:
8-Isoquinolinecarbonitrile(9CI) is used as a key intermediate in the synthesis of pharmaceutical drugs due to its unique chemical structure and biological activities. Its potential as an anti-tumor, antiviral, and antibacterial agent makes it a valuable component in the creation of new medications targeting a range of diseases.
Used in Organic Synthesis:
In the field of organic synthesis, 8-Isoquinolinecarbonitrile(9CI) serves as a versatile building block for the production of various organic compounds. Its reactivity and structural features facilitate the synthesis of complex organic molecules, contributing to the advancement of organic chemistry.
Used in Biochemical Research:
8-Isoquinolinecarbonitrile(9CI) is utilized as a research tool in biochemical studies, particularly for investigating enzyme inhibition. Its moderate to high inhibitory activity against certain enzymes aids researchers in understanding enzyme functions and developing enzyme-targeted therapies.
Used in Antiviral Applications:
8-Isoquinolinecarbonitrile(9CI) is employed as an antiviral agent, leveraging its potential to inhibit viral replication and reduce the severity of viral infections. Its antiviral properties are being explored for the development of treatments against various viral diseases.
Used in Antibacterial Applications:
8-Isoquinolinecarbonitrile(9CI) is used as an antibacterial agent, exhibiting properties that can inhibit bacterial growth and combat infections. Its potential in this area is significant for the development of new antibiotics to address the growing issue of antibiotic resistance.

InChI:InChI=1/C10H6N2/c11-6-9-3-1-2-8-4-5-12-7-10(8)9/h1-5,7H

Upstream product

• 63927-22-0 8-bromo-isoquinoline 
• 557-21-1 zinc(II) cyanide 

Downstream Products

• 61563-43-7 isoquinoline-8-carboxylic acid 
• 850858-56-9 8-isoquinolinecarboxylic acid methyl ester 
• 362606-12-0 isoquinolin-8-ylmethanamine 

Relevant articles and documents

AMINOPYRAZINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES

Disclosed are compounds of Formula A and Formula A-1, or a salt thereof, and pharmaceutical formulations (pharmaceutical compositions) comprising those compounds, or a salt thereof; wherein "R1", "RA-1", "R2", "R3", and "Het" are defined herein above, which compounds are believed suitable for use in selectively antagonizing the A2a receptors, for example, those found in high density in the basal ganglia. Such compounds and pharmaceutical formulations are believed to be useful in treatment or management of neurodegenerative diseases, for example, Parkinson's disease, or movement disorders arising from use of certain medications used in the treatment or management of Parkinson's disease.