Synthesis and biological evaluation of novel benzo[c][1,2,5]thiadiazol-5-yl and thieno[3,2-c]- pyridin-2-yl imidazole derivatives as ALK5 inhibitors
Transforming growth factor (TGF-β), a key mediator of tumor growth and metastasis, has been recognized as an important cancer drug target. A series of benzo[c][1,2,5]thiadiazol-5-yl imidazoles (14a–g) and thieno[3,2-c]-pyridin-2-yl imidazoles (20a–g) were
Guo, Zhen,Song, Xiaowei,Zhao, Li-Min,Piao, Ming Guan,Quan, Jishan,Piao, Hu-Ri,Jin, Cheng Hua
Triarylimidazole derivatives as cytokine inhibitors
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2 and R3 are various substituent groups; and one of X1 and X2 is N or CR″, and the other is NR″ or CHR″ wherein R″
-
(2008/06/13)
More Articles about upstream products of 364050-15-7