- METHOD OF SYNTHESIS OF 5,6?BIS(5?ALKOXYTHIOPHEN?2?YL)PYRAZINE-2,3-DICARBONITRILES, DERIVATIVES OF DICYANOPYRAZINE AND USE THEREOF
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The present invention relates to a method of synthesis of compounds of general formula (I) wherein R is linear or branched (C1-C8) alkyl, (C5-C6) cycloalkyl or benzyl, the method comprising the following steps: 10 step a) Friedel-Crafts reaction of thioph
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Page/Page column 7; 8
(2019/10/19)
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- Practical Ligand-Free Copper-Catalysed Short-Chain Alkoxylation of Unactivated Aryl Bromides
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An efficient and practical short-chain alkoxylation of unactivated aryl bromides has been developed with special attention focussed on the applicability of the reaction. Sodium alkoxide is used as the nucleophile, and the corresponding alcohol as the solvent. The reaction requires neither precious metals nor organic ligands. It uses a catalytic system consisting of copper(I) bromide as a catalyst, the corresponding alkyl formate as a noncontaminating cocatalyst, and lithium chloride as an additive. A wide range of substrates and test cases highlight the synthetic utility of the approach. Considering the commercial accessibility and affordability of the feedstocks, this protocol shows promise as a new alternative for the sustainable preparation of aryl alkyl ethers.
- Guo, Ying,Fan, Xue-Min,Nie, Min,Liu, Hong-Wei,Liao, Dao-Hua,Pan, Xian-Dao,Ji, Ya-Fei
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p. 4744 - 4755
(2015/08/03)
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- ANTIBACTERIAL AGENTS: ARYL MYXOPYRONIN DERIVATIVES
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The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
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Page/Page column 89
(2014/01/09)
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- PHOTOCHROMIC MATERIAL
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A photochromic material having a ring opening quantum yield of 10-3 or lower which does not fade under ambient light is provided. The material comprises a compound belonging to the diheteroarylethene class. The compound has alkoxy group and ary
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- Antitumor compositions and methods of treatment
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This invention provides certain sulfonamide compounds, formulations and method of use of certain sulfonamide compounds in treating susceptible neoplasms.
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- Copper(I) Halide Catalysed Synthesis of Alkyl Aryl and Alkyl Heteroaryl Ethers
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A number of alkyl aryl and alkyl heteroaryl ethers have been prepared from (hetero) aryl halides (mainly bromides) and sodium alkoxides, using copper(I)bromide as a catalyst.The influence of the main solvent, the halogen atom, reaction temperature and the presence of oxygen upon the rate and selectivity has been studied.Furthermore the decomposition of the catalyst and the reduction of the aryl halide are studied.
- Keegstra, Menno A.,Peters, Theo H. A.,Brandsma, Lambert
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p. 3633 - 3652
(2007/10/02)
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