365413-19-0

Basic information

• Product Name: 5-Iodo-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid
• Synonyms: 5-Iodo-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid;1,6-dihydro-5-iodo-6-oxo-3-Pyridinecarboxylic acid;6-Hydroxy-5-iodopyridine-3-carboxylicacid
• CAS NO: 365413-19-0
• Molecular Formula: C₆H₄INO₃
• Molecular Weight: 265.00533
• EINECS: -0
• Mol File: 365413-19-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Iodo-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Iodo-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid(365413-19-0)
• EPA Substance Registry System: 5-Iodo-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid(365413-19-0)

Safety Data

• Hazardous Substances Data: 365413-19-0(Hazardous Substances Data)

Upstream product

• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 

Downstream Products

• 1269826-44-9 5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide 
• 1361748-71-1 6-chloro-5-(3,4-dichloro-phenyl)-nicotinic acid 
• 1373754-96-1 5-(3,4-dichloro-phenyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinic acid 
• 365413-29-2 6-chloro-5-iodonicotinic acid methyl ester 
• 1361567-63-6 C₁₃H₈Cl₃NO₂ 

Relevant articles and documents

Development of a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on kilogram scale

Reported herein is a safe and economical synthesis of methyl 6-chloro-5-(trifluoromethyl)nicotinate, an intermediate in the synthesis of novel anti-infective agents. The key to this process is the trifluoromethylation of an aryl iodide using an inexpensive methyl chlorodifluoroacetate (MCDFA)/KF/CuI system, with an emphasis on the development work which led to this effective process.

PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES

The present invention relates to a process for the preparation of nicotinamide derivatives of the formula (I) R1 to R7 are as defined in the and to pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful for the treatment and / or prophylaxis of diseases which are associated with the modulation of cannabinoid 1 receptors (CB 1 receptors) as described in the PCT Publ. WO 2006/106054.

PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES

The present invention relates to a process for the preparation of nicotinamide derivatives of formula I, wherein R1 to R7 are as defined above and to pharmaceutically acceptable salts thereof. The compounds of formula I are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of cannabinoid 1 receptors (CB1 receptors) as described in the PCT Publ. WO 2006/106054.