1269826-44-9

Upstream product

• 1269826-46-1 5-Bromo-N-((1R,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide 
• 151169-75-4 3,4-dichlophenylboronic acid 
• 29241-62-1 5-bromo-6-chloronicotinic acid 
• 1211586-75-2 5-bromo-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid 
• 5006-66-6 6-hydroxy-3-pyridinecarboxylic acid 
• 66171-50-4 methyl 6-hydroxynicotinate 
• 885950-46-9 6-hydroxy-5-iodonicotinic acid methyl ester 
• 365413-29-2 6-chloro-5-iodonicotinic acid methyl ester 
• 365413-19-0 6-hydroxy-5-iodonicotinic acid 
• 13374-31-7 (1R,2R)-trans-2-aminocyclohexanol hydrochloride 
• 1361748-71-1 6-chloro-5-(3,4-dichloro-phenyl)-nicotinic acid 
• 1361567-63-6 C₁₃H₈Cl₃NO₂ 

Relevant academic research and scientific papers

PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES

The present invention relates to a process for the preparation of nicotinamide derivatives of formula I, wherein R1 to R7 are as defined above and to pharmaceutically acceptable salts thereof. The compounds of formula I are useful for the treatment and/or prophylaxis of diseases which are associated with the modulation of cannabinoid 1 receptors (CB1 receptors) as described in the PCT Publ. WO 2006/106054.

PROCESS FOR THE PREPARATION OF NICOTINAMIDE DERIVATIVES

The present invention relates to a process for the preparation of nicotinamide derivatives of the formula (I) R1 to R7 are as defined in the and to pharmaceutically acceptable salts thereof. The compounds of formula (I) are useful for the treatment and / or prophylaxis of diseases which are associated with the modulation of cannabinoid 1 receptors (CB 1 receptors) as described in the PCT Publ. WO 2006/106054.

5- (3, 4-DICHLORO-PHENYL) -N- (2-HYDROXY-CYCLOHEXYL) -6- (2,2, 2-TRIFLUORO-ETHOXY) -NICO TINAMIDE AND SALTS THEREOF AS HDL CHOLESTEROL RAISING AGENTS

The present invention relates to a compound of the formula in all its isomeric forms and pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as preferably dyslipidemia, atherosclerosis and cardiovascular diseases.

5-(3,4-DICHLORO-PHENYL)-N-(2-HYDROXY-CYCLOHEXYL)-6-(2,2,2-TRIFLUORO-ETHOXY)-NICOTINAMIDE AND SALTS THEREOF

The present invention relates to a compound of formula I, in all its isomeric forms and pharmaceutically acceptable salts thereof, their manufacture, pharmaceutical compositions containing them and their use as medicaments for the treatment and/or prophylaxis of diseases which can be treated with HDL-cholesterol raising agents, such as dyslipidemia, atherosclerosis and cardiovascular diseases.