365413-31-6

Basic information

• Product Name: tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate
• Synonyms: 4-[4-(ETHOXYCARBONYL)-1,3-THIAZOL-2-YL]PIPERIDINE, N-BOC PROTECTED;TERT-BUTYL-4-[4-(ETHOXYCARBONYL)-1,3-THIAZOL-2-YL]-PIPERAZINE-1-CARBOXYLATE;TERT-BUTYL 4-[4-(ETHOXYCARBONYL)-1,3-THIAZOL-2-YL]PIPERIDINE-1-CARBOXYLATE;TERT-BUTYL 4-[4-(ETHOXYCARBONYL)-1,3-THIAZOL-2-YL]TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE;tert-Butyl-4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]-piperizine-1-carboxylate;t-butyl4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2h)-pyridinecarboxylate;4-[4-(Ethoxycarbonyl)-1,3-thiazol-2-yl]piperidine, N-BOC protected 95%;BOC-4-[4-(ETHOXYCARBONYL)-1,3-THIAZOL-2-YL]PIPERIDINE
• CAS NO: 365413-31-6
• Molecular Formula: C₁₆H₂₄N₂O₄S
• Molecular Weight: 341.43
• Mol File: 365413-31-6.mol

Chemical Properties

• Melting Point: 71 °C
• Boiling Point: 444.9 °C at 760 mmHg
• Flash Point: 222.8 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 4.14E-08mmHg at 25°C
• Refractive Index: 1.533
• Storage Temp.: Refrigerated.
• PKA: 0.75±0.10(Predicted)
• CAS DataBase Reference: tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate(365413-31-6)
• EPA Substance Registry System: tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate(365413-31-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 365413-31-6(Hazardous Substances Data)

Usage

Uses

Used in Scientific Research:
Tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate is used as a research chemical for [application reason], contributing to the advancement of scientific knowledge in various fields. Its complex structure and composition make it a valuable subject for study in chemical synthesis, structural analysis, and potential applications in material science or pharmaceutical research.
Used in Pharmaceutical Development:
In the pharmaceutical industry, tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate is used as a potential drug candidate for [application reason]. Its unique chemical structure may offer new avenues for the development of novel therapeutic agents, particularly in the areas of medicinal chemistry and drug discovery. tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate's properties and interactions with biological systems are of interest to researchers seeking to understand its potential as a new drug entity.
Used in Material Science:
In the field of material science, tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate is used as a component in the development of new materials for [application reason]. Its chemical properties and structural characteristics may contribute to the creation of innovative materials with unique properties, such as improved stability, reactivity, or selectivity in various applications. Researchers in this field are interested in exploring the compound's potential for enhancing material performance and functionality.

InChI:InChI=1/C16H24N2O4S/c1-5-21-14(19)12-10-23-13(17-12)11-6-8-18(9-7-11)15(20)22-16(2,3)4/h10-11H,5-9H2,1-4H3

Upstream product

• 375853-82-0 tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate 
• 91419-48-6 4-carbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 5398-36-7 2-aminothiazole-4-carboxylate 
• 922516-53-8 ethyl 2-(1-(tert-butoxycarbonyl)-1,2,3,6-tetrahydropyridin-4-yl)thiazole-4-carboxylate 
• 100367-77-9 ethyl 2-bromothiazole-4-carboxylate 
• 137076-22-3 tert butyl 4-formylpiperidine-1-carboxylate 
• 139290-70-3 tert-butyl 4-(methoxy(methyl)carbamoyl)piperidine-1-carboxylate 
• 84358-13-4 N-[(tert-butoxy)carbonyl]piperidine-4-carboxylic acid 
• 1192878-45-7 4-(2-ethoxycarbonyl-2-oxo-ethylsulanylcarbonimidoyl)-piperidine-1-carboxylic acid tert-butyl ester 
• 214834-18-1 tert-butyl 4-carbamothioylpiperidine-1-carboxylate 
• 70-23-5 ethyl Bromopyruvate 
• 881197-94-0 4-(4-ethoxycarbonyl-4,5-dihydrothiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 365413-00-9 4-(4-carboxy-thiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester 
• 1148104-71-5 5-(2,6-difluorophenyl)-3-(2-(piperidin-4-yl)thiazol-4-yl)-4,5-dihydroisoxazole 
• 922516-01-6 1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylethyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate 
• 922515-97-7 1,1-dimethylethyl 4-[4-[[methyl[(1R)-1-phenylpropyl]amino]-carbonyl]-2-thiazolyl]-1-piperidinecarboxylate 
• 922515-98-8 N-methyl-N-[(1R)-1-phenylpropyl]-2-(4-piperidinyl)-4-thiazolecarboxamide 

Relevant articles and documents

1 -(4-(4-(5-PHENYL-4,5-DIHYDROISOXAZOL-3-YL)THIAZOL-2-YL)PIPERIDIN-1 -YL)-ETHAN-1 -ONE DERIVATIVES AND RELATED COMPOUNDS AS FUNGICIDES FOR CROP PROTECTION

The present invention relates to 1-(4-(4-(5-phenyl-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-1-yl)-ethan-1-one derivatives and related compounds for use as fungicides for crop protection, as well as to a process for preparing the same. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 55 to 94; examples 1 to 4; compounds 1 to 194; table 1).

1-(4-(4-(5-PHENYL-4,5-DIHYDROISOXAZOL-3-YL)THIAZOL-2-YL)PIPERIDIN-1-YL)-ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FUNGICIDES FOR CROP PROTECTION

The present invention relates to 1-(4-(4-(5-phenyl-4,5- dihydroisoxazol-3-yl)thiazol-2-yl)piperidin-l-yl)-ethan-l-one derivatives and related compounds as fungicides for crop protection. The present description discloses the synthesis and characterisation of exemplary compounds as well as biological data thereof (e.g. pages 47 to 69; examples 1 to 4; compounds 1 to 81; table 1). An exemplary compound is e.g. 1-(4-(4-(5-(2,6-dichlorophenyl) -4,5-dihydroisoxazol-3-yl)thiazol-2-yl) piperidin-1-yl)-2-((3- methoxypyridin-2-yl)oxy)ethan-1-on ( example 1 ).

NOVEL SULFILIMINES OR SULFOXIMINES CONTAINING FUNGICIDAL HETEROCYCLIC COMPOUNDS

The present invention relates to a compound formula (I) and a process for preparing the same, wherein, R2, A, E, Hy, Ra, n, Q and W1 are each as defined in the description. The invention also relates to the combination and composition comprising the compound of formula (I).

Synthetic method and application of piperidyl thiazole formamide compound

The invention relates to a 2-(4-piperidyl)-thiazole-4-formamide compound and a synthetic method and medicinal evaluation thereof. The synthetic method comprises the following steps: carrying out a substitution reaction between N-Boc-4-piperidine-carboxylic acid and ammonium chloride to prepare an intermediate 2; carrying out a thiolation reaction between the compound 2 and a Lawesson reagent to obtain an intermediate 3; carrying out a reaction between the compound 3 and ethyl bromopyruvate to obtain an intermediate 4; carrying out esterolysis on the compound 4 to obtain a compound 5; carryingout a reaction between the compound 5 and ammonia to obtain an intermediate 6; deprotecting the Boc protected compound 6 to obtain a compound 7; performing acid condensation on the compound 7 to obtain an intermediate 8; deprotecting the Boc protected intermediate 8 to obtain a compound 9; and carrying out a reaction between the compound 9 and different isocyanates to obtain a final product. An MTT method is adopted for tests, and it shows that part of the 2-(4-piperidyl)-thiazole-4-formamide compounds have certain anti-tumor activity, wherein the antitumor activity of a compound 10f-10m is superior to that of a compound 10a-10d.

NOVEL FUNGIDAL HETEROCYCLIC COMPOUNDS

The present invention relates to a compound selected from Formula (I) and its salts, metal complexes, N-oxides, isomers, and polymorphs: Formula (I) wherein E, Z, R3, n, G, J & Q have the meaning as defined in the description.

NOVEL FUNGICIDAL HETEROCYCLIC COMPOUNDS

The present invention relates to a compound selected from Formula I and a process for preparing same, wherein R2, T, L1, A, G, J, n, W, Z and Z1 are each as defined in the description. The invention also relates to the combination and composition comprising the compound of Formula I.

HETEROCYCLIC COMPOUNDS WITH MICROBIOCIDAL PROPERTIES

The present disclosure relates to a compound of Formula I, wherein the substituents T, A, W, R2, n, Z, G, Z1 and J are as defined in the description.

IMIDAZOTHIADIAZOLE AND IMIDAZOPYRAZINE DERIVATIVES AS PROTEASE ACTIVATED RECEPTOR 4 (PAR4) INHIBITORS FOR TREATING PLATELET AGGREGATION

The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.

OXADIAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compound of formula (I) and pharmaceutically acceptable salt thereof, wherein R1-R5 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

Novel NIP Thiazole Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydroge-Nase-1

The present invention relates to NIP thiazole derivatives of formula (I) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.