- Pyridazone derivative and its uses
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The present invention belongs to the pharmaceutical field, specifically relates to a pyridazone derivative and its uses, compounds thereof and pharmaceutically acceptable salts, solvates including hydrates, polycrystallines, prodrugs, co-crystallines, tau
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Paragraph 0148
(2022/01/12)
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- Noncovalent Interactions in Ir-Catalyzed C-H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters
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An efficient strategy for the para-selective borylation of aromatic esters is described. For achieving high para-selectivity, a new catalytic system has been developed modifying the core structure of the bipyridine. It has been proposed that the L-shaped ligand is essential to recognize the functionality of the oxygen atom of the ester carbonyl group via noncovalent interaction, which provides an unprecedented controlling factor for para-selective C-H activation/borylation.
- Hoque, Md Emdadul,Bisht, Ranjana,Haldar, Chabush,Chattopadhyay, Buddhadeb
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supporting information
p. 7745 - 7748
(2017/06/21)
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- A new versatile synthesis of esters from Grignard reagents and chloroformates
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Cross-coupling reactions of chloroformates with organocopper reagents, derived from Grignard reagents, cuprous bromide and lithium bromide, provide a rapid and straightforward method for the synthesis of esters. Georg Thieme Verlag Stuttgart.
- Bottalico, Daniela,Fiandanese, Vito,Marchese, Giuseppe,Punzi, Angela
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p. 974 - 976
(2008/02/02)
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- Facile esterification of sulfonic acids and carboxylic acids with triethylorthoacetate
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Triethylorthoacetate was found to be surprisingly more effective than triethylorthoformate in the esterification of sulfonic acids and carboxylic acids. Using this reagent, esters of sulfonic and carboxylic acids are prepared in high yields.
- Trujillo, John I.,Gopalan, Aravamudan S.
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p. 7355 - 7358
(2007/10/02)
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- Synthesis, Characterization, and X-ray Structure of the Ruthenium "Picnic-Basket" Porphyrins
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The synthesis and characterization of a new class of sterically protected porphyrins, the "picnic-basket" porphyrins, are presented.These tetraarylporphyrins, which were prepared as cytochrome P-450 active-site analogues, bear a rigid superstucture on one face of the porphyrin macrocycle.The cavity defined by the appended superstructure may be readily varied in size, chirality, and functionality.In addition, the synthesis and characterization, including an X-ray structure, of several ruthenium picnic-basket porphyrin carbonyl complexes are reported.The regiochemistry of axial ligation in these ruthenium derivatives has been determined by 1H NMR spectroscopy.
- Collman, James P.,Brauman, John I.,Fitzgerald, Jeffrey P.,Hampton, Philip D.,Naruta, Yoshinori,et al.
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p. 3477 - 3486
(2007/10/02)
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- RAPID SOLVOLYSES OF 2,6-DIMETHYL- AND 2,4,6-TRIMETHYL-BENZOYL CHLORIDES: MODEL SYSTEMS FOR SOLVENT EFFECTS ON THE REACTIVITY OF ACID CHLORIDES
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Rates of solvolyses of 2,6-dimethyl- and 2,4,6-trimethyl-benzoyl (mesitoyl) chlorides are reported for aqueous binary mixtures with acetone, ethanol, and methanol.These data are compared with those obtained for solvolyses of p-methoxybenzoyl (anisoyl) chloride.A consistent definition of selectivity is proposed to remove ambiguities in published values.Selectivities (S) for formation of ester relative to acid in alcohol-water mixtures are almost independent of solvent composition and are inverse for ethanol mixtures; methanol mixtures show higher S values.Acid catalysis does not appear to be significant.The results show that, for solvolyses of acid chlorides, a solvation effect and possibly a mass law effect increase the reaction rates in methanol-water mixtures as compared with those in ethanol-water mixtures having the same Y value.Differences between the mechanism of solvolyses of mesitoyl and anisoyl chlorides are revealed by rate enhancements with added m-nitroaniline, and by a comparison of m-values.Experience of recent conductimetric studies of a wide range of relatively rapid solvolytic rections is summarised.
- Bentkey, T. William,Harris, H. Carl,Koo, In Sun
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p. 783 - 790
(2007/10/02)
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